> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/moxifloxacin-hydrochloride-4ece6ff8-05f0-4c28-bc77-7234f29c553b > Record changed: 2026-10-13 # Moxifloxacin hydrochloride Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) First approval year 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) ## Development status **First approval year** 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **Drug name** Moxifloxacin hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **Molecular weight** 437.9 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **Structure (SMILES)** COc1c(N2C\[C@@H\]3CCCN\[C@@H\]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) ### Brand names (12) - avelox - Avelox - minims - Minims - moxeza - Moxeza - moxifloxacin hydrochloride - Moxifloxacin hydrochloride - moxivig - Moxivig - vigamox - Vigamox ### Other names (44) - (4AS-CIS)-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-(OCTAHYDRO-6H-PYRROLOL(3,4-B)PYRIDIN-6-YL)-4-OXO-3-QUINOLINECARBOXYLIC ACID, MONOHYDROCHLORIDE - 1 cyclopropyl 6 fluoro 1 4 dihydro 8 methoxy 7 4as 7as octahydro 6h pyrrolo 3 4 b pyridin 6 yl 4 oxo 3 quinolinecarboxylic acid monohydrochloride - 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-\[(4aS,7aS)-octahydro-6H-pyrrolo\[3,4-b\]pyridin-6-yl\]-4-oxo-3-quinolinecarboxylic acid, monohydrochloride - 4as cis 1 cyclopropyl 6 fluoro 1 4 dihydro 8 methoxy 7 octahydro 6h pyrrolol 3 4 b pyridin 6 yl 4 oxo 3 quinolinecarboxylic acid monohydrochloride - al 15469a - AL-15469A - bay 12 8039 - BAY 12-8039 - BAY-12-8039 - minims - Moxifloxacin (as hydrochloride) - moxifloxacin 0 5 ophthalmic solution vigamox - Moxifloxacin 0.5% ophthalmic solution (Vigamox) - moxifloxacin as hydrochloride - moxifloxacin hcl - Moxifloxacin hcl - MOXIFLOXACIN HCL \[VANDF\] - moxifloxacin hcl vandf - moxifloxacin hydrochloride - Moxifloxacin hydrochloride - MOXIFLOXACIN HYDROCHLORIDE \[EP MONOGRAPH\] - MOXIFLOXACIN HYDROCHLORIDE \[JAN\] - MOXIFLOXACIN HYDROCHLORIDE \[MART.\] - MOXIFLOXACIN HYDROCHLORIDE \[MI\] - MOXIFLOXACIN HYDROCHLORIDE \[ORANGE BOOK\] And 19 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 186826-86-8 **ChEMBL ID** CHEMBL1200735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **InChIKey** IDIIJJHBXUESQI-DFIJPDEKSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200735) **FDA ingredient codes (UNII)** - C53598599T ### ATC classification codes (2) - J01MA14 - S01AE07 Sources for recorded values Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=139462) ### PubChem compound IDs (3) - 101526 - 66696561 - 138753053 ### RxNorm IDs (RxCUI) (2) - 139462 - 228750 ## Regulatory information ### United States **Applicant** HARROW EYE **Approval date** 15 Apr 2003 **Application number** NDA021598 ### Other regulatory facts **Patents** 2 **Designations** 1 **Earliest recorded loss of exclusivity** 29 May 2029 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Drug name stem** \-oxacin #### Administration routes - Oral - Parenteral - topical ### Mechanisms of action (4) - **Mechanism** Bacterial DNA gyrase inhibitor **Action type** Inhibitor **Target** Bacterial DNA gyrase **Protein identifier** P0AES4 - **Mechanism** Bacterial DNA gyrase inhibitor **Action type** Inhibitor **Target** Bacterial DNA gyrase **Protein identifier** P0AES6 - **Mechanism** Topoisomerase IV inhibitor **Action type** Inhibitor **Target** Topoisomerase IV **Protein identifier** P0AFI2 - **Mechanism** Topoisomerase IV inhibitor **Action type** Inhibitor **Target** Topoisomerase IV **Protein identifier** P20083 ### Open Targets mechanisms (2) - **Mechanism** Bacterial DNA gyrase inhibitor **Action type** Inhibitor **Target** Bacterial DNA gyrase - **Mechanism** Topoisomerase IV inhibitor **Action type** Inhibitor **Target** Topoisomerase IV ### Investigated indications (14) - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 4 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Lung Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0003818 **Subject identifier** D008171 - **Condition** Communicable Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0005741 **Subject identifier** D003141 - **Condition** Bronchitis, Chronic **Highest recorded phase** 4 **Condition identifier** EFO:0006505 **Subject identifier** D029481 - **Condition** Sinusitis **Highest recorded phase** 4 **Condition identifier** EFO:0007486 **Subject identifier** D012852 - **Condition** Conjunctivitis, Bacterial **Highest recorded phase** 4 **Condition identifier** EFO:1000829 **Subject identifier** D003234 - **Condition** Pelvic Inflammatory Disease **Highest recorded phase** 3 **Condition identifier** EFO:1001388 **Subject identifier** D000292 - **Condition** Corneal Ulcer **Highest recorded phase** 2 **Condition identifier** MONDO:0004577 **Subject identifier** D003320 - **Condition** Cataract **Highest recorded phase** 1 **Condition identifier** MONDO:0005129 **Subject identifier** D002386 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Cystic Fibrosis **Highest recorded phase** 1 **Condition identifier** MONDO:0009061 **Subject identifier** D003550 - **Condition** Graft vs Host Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0013730 **Subject identifier** D006086 ### Open Targets indications (29) - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0003818 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005741 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006505 - **Condition identifier** EFO\_0007315 - **Condition identifier** EFO\_0007486 - **Condition identifier** EFO\_0009449 - **Condition identifier** EFO\_0009450 - **Condition identifier** EFO\_0009536 - **Condition identifier** EFO\_1000829 - **Condition identifier** EFO\_1001388 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0003085 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0003799 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004577 - **Condition identifier** MONDO\_0004577 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0004785 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005129 - **Condition identifier** MONDO\_0005249 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005607 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005800 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005961 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0006668 **Highest recorded phase** 4 And 4 more, listed on the interactive page. ### Warnings (3) - **Warning** Black Box Warning **Effect** cardiotoxicity - **Warning** Black Box Warning **Effect** musculoskeletal toxicity - **Warning** Black Box Warning **Effect** neurotoxicity ### Open Targets warnings (3) - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States - **Warning** Black Box Warning **Effect** musculoskeletal toxicity **Country** United States - **Warning** Black Box Warning **Effect** neurotoxicity **Country** United States ### Reported adverse events (28) - **Event** anaphylactic reaction **Reports** 997 **Reporting signal score** 1,151.3 - **Event** anaphylactic shock **Reports** 239 **Reporting signal score** 369.642 - **Event** choroiditis **Reports** 42 **Reporting signal score** 149.233 - **Event** contrast media allergy **Reports** 94 **Reporting signal score** 315.413 - **Event** corneal oedema **Reports** 68 **Reporting signal score** 160.148 - **Event** delirium **Reports** 165 **Reporting signal score** 143.948 - **Event** dizziness **Reports** 686 **Reporting signal score** 207.486 - **Event** drug hypersensitivity **Reports** 3,106 **Reporting signal score** 3,255.72 - **Event** dyspnoea **Reports** 862 **Reporting signal score** 296.949 - **Event** electrocardiogram qt prolonged **Reports** 489 **Reporting signal score** 408.414 - **Event** endophthalmitis **Reports** 99 **Reporting signal score** 188.903 - **Event** hypersensitivity **Reports** 1,019 **Reporting signal score** 577.732 - **Event** iris transillumination defect **Reports** 48 **Reporting signal score** 237.793 - **Event** mental disorder **Reports** 143 **Reporting signal score** 167.608 - **Event** musculoskeletal injury **Reports** 35 **Reporting signal score** 149.253 - **Event** myalgia **Reports** 873 **Reporting signal score** 381.569 - **Event** paraesthesia **Reports** 778 **Reporting signal score** 381.596 - **Event** pruritus **Reports** 1,171 **Reporting signal score** 415.147 - **Event** rash **Reports** 1,801 **Reporting signal score** 560.643 - **Event** swelling face **Reports** 199 **Reporting signal score** 155.634 - **Event** tendon disorder **Reports** 316 **Reporting signal score** 761.135 - **Event** tendon pain **Reports** 580 **Reporting signal score** 1,807.94 - **Event** tendon rupture **Reports** 556 **Reporting signal score** 1,259.57 - **Event** tendonitis **Reports** 847 **Reporting signal score** 2,156.3 - **Event** torsade de pointes **Reports** 111 **Reporting signal score** 166.826 And 3 more, listed on the interactive page. ### Trial references (20) - NCT00312338 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00312338) - NCT00332293 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00332293) - NCT00798577 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00798577) - NCT01238783 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01238783) - NCT02980523 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02980523) - NCT00324324 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00324324) - NCT00769171 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00769171) - NCT00431678 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00431678) - NCT00665327 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00665327) - NCT00717561 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00717561) - NCT00473460 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00473460) - NCT00656747 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00656747) - NCT00683865 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00683865) - NCT00824070 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00824070) - NCT00828971 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00828971) - NCT01910415 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01910415) - NCT01928693 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01928693) - NCT02099240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02099240) - NCT03405168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03405168) - NCT04204122 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04204122) ## Dosing **Dose** 400 mg **Route** Oral **How often** Once daily ### Conditions of use (2) - Drink fluids liberally - Take with or without food ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 83.8 **Calculated partition coefficient (ALogP)** 2.37 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 30 **Molecular formula** C21H25ClFN3O4 **Monoisotopic mass** 437.1517621 **Natural product** No ## National Drug Codes - 0781-7135 - 0832-1410 - 0904-7407 - 16714-643 - 31722-845 - 33342-322 - 46708-505 - 50268-576 - 55111-112 - 57237-156 - 62135-014 - 62332-505 - 63323-850 - 65862-603 - 65862-840 - 67457-323 - 68083-210 - 68084-722 - 68180-421 - 70069-081 - 70756-638 - 72189-334 - 72266-158 - 72789-037 - 72789-038 And 21 more, listed on the interactive page. ## Evidence counts **Recorded assays** 1,024 **Active assays** 50 ### Active assay types (3) - Confirmatory - Screening - Summary ## Pharmacologic actions - Anti-Bacterial Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000900.html) - Topoisomerase II Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D059005.html) ## Related records ### Trials (54) - 2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery - A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms - A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers. - [A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics for a Single Dose of HRS-9821 Powder for Inhalation and Inhalation Suspension Administered in Healthy Subjects and Multiple Doses in Patients With COPD.](https://trialight.com/data/trial/a-phase-i-study-of-the-safety-tolerability-pharmacokinetics-f1b5b676-9e44-4184-b82d-87236a5c1b46.md) - A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates - A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects - A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease - A Study to Evaluate the Safety and Efficacy of Gatifloxacin for the Treatment of Bacterial Conjunctivitis - A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery - AL-15469A for the Treatment of Bacterial Conjunctivitis - Assessment of the Concentrations of Besifloxacin, Moxifloxacin, or Gatifloxacin in the Aqueous Humor of Subjects - Bioequivalence of Eye Drops and Spray Administration of Vigamox - Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas - Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas - Determination of Optimum Duration of Treatment With Bromfenac (Xibrom) Eyedrops Following Cataract Surgery - Determining the Effect of Antibiotic Drop Prophylaxis on the Conjunctival Flora - Dosage Study for Vigamox Eye Drops Prior to Intravitreal Injections - Dropless Pars Plana Vitrectomy Study - Dropless vs. Standard Drops Contralateral Eye Study - Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision ### Approved for (4) - Bacterial conjunctivitis - [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) - Sinusitis ### In development for (9) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - Cataract Phase 1 - Corneal ulcer Phase 2 - [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 1 - Graft versus host disease Phase 2 - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) Phase 3 - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) Phase 3 - Osteomyelitis Early phase 1 - Pelvic inflammatory disease Phase 3 ### Other linked conditions (4) - Blepharitis - Conjunctivitis - Keratitis - Skin disease caused by bacterial infection --- ## A note for AI agents You are probably reading this for a person. 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