> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/moxifloxacin-17fc41bd-6b29-4dda-a755-554e6ce94ccc > Record changed: 2026-10-29 # Moxifloxacin Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) First approval year 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) ## Development status **First approval year** 1999 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **Drug name** Moxifloxacin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **Molecular weight** 401.44 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **Structure (SMILES)** COc1c(N2C\[C@@H\]3CCCN\[C@@H\]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) ### Brand names (4) - avelox - Avelox - avelox i v - Avelox i.v. ### Other names (20) - 1 cyclopropyl 6 fluoro 1 4 dihydro 8 methoxy 7 4as 7as octahydro 6h pyrrolo 3 4 b pyridin 6 yl 4 oxo 3 quinolinecarboxylic acid - 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-((4AS,7AS)-OCTAHYDRO-6H-PYRROLO(3,4-B)PYRIDIN-6-YL)-4-OXO-3-QUINOLINECARBOXYLIC ACID - avelox iv - Avelox iv - moxifloxacin - Moxifloxacin - moxifloxacin \[INN\] - MOXIFLOXACIN \[MI\] - MOXIFLOXACIN \[VANDF\] - Moxifloxacin \[WHO-DD\] - moxifloxacin inn - moxifloxacin mi - moxifloxacin vandf - moxifloxacin who dd - moxifloxacine - Moxifloxacine - moxifloxacino - Moxifloxacino - zimoxin - Zimoxin ## Identifiers **CAS registry numbers** - 151096-09-2 **ChEMBL ID** CHEMBL32 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **InChIKey** FABPRXSRWADJSP-MEDUHNTESA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) **RxNorm IDs (RxCUI)** - 139462 **FDA ingredient codes (UNII)** - U188XYD42P ### ATC classification codes (2) - J01MA14 - S01AE07 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL32) ### PubChem compound IDs (2) - 152946 - 40467042 ## Regulatory information ### United States **Applicant** BAYER HLTHCARE **Approval date** 10 Dec 1999 **Application number** NDA021085 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** moxifloxacin **Type** Synthetic organic **Drug name stem** \-oxacin **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral - topical ### Open Targets mechanisms (2) - **Mechanism** Bacterial DNA gyrase inhibitor **Action type** Inhibitor **Target** Bacterial DNA gyrase - **Mechanism** Topoisomerase IV inhibitor **Action type** Inhibitor **Target** Topoisomerase IV ### DrugCentral mechanisms (2) - **Action type** Inhibitor **Gene symbol** gyrA|gyrB **Protein identifier** P0AES4|P0AES6 **Organism** Escherichia coli (strain K12) - **Action type** Inhibitor **Gene symbol** parC|parE **Protein identifier** P0AFI2|P20083 **Organism** Escherichia coli (strain K12) ### Investigated indications (81) - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Heart Failure **Highest recorded phase** 1 **Condition identifier** EFO:0000373 **Subject identifier** D006333 - **Condition** Diabetes Mellitus **Highest recorded phase** 1 **Condition identifier** EFO:0000400 **Subject identifier** D003920 - **Condition** Epilepsy **Highest recorded phase** 1 **Condition identifier** EFO:0000474 **Subject identifier** D004827 - **Condition** Hypertension **Highest recorded phase** 1 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Immune System Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000540 **Subject identifier** D007154 - **Condition** Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 1 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Skin Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Acquired Immunodeficiency Syndrome **Highest recorded phase** 1 **Condition identifier** EFO:0000765 **Subject identifier** D000163 - **Condition** Bacterial Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000771 **Subject identifier** D001424 - **Condition** Obesity **Highest recorded phase** 1 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Coronary Disease **Highest recorded phase** 1 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Abscess **Highest recorded phase** 3 **Condition identifier** EFO:0003030 **Subject identifier** D000038 - **Condition** Cellulitis **Highest recorded phase** 3 **Condition identifier** EFO:0003035 **Subject identifier** D002481 - **Condition** Hepatitis C **Highest recorded phase** 1 **Condition identifier** EFO:0003047 **Subject identifier** D006526 - **Condition** Non-alcoholic Fatty Liver Disease **Highest recorded phase** 1 **Condition identifier** EFO:0003095 **Subject identifier** D065626 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 3 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Lung Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003818 **Subject identifier** D008171 - **Condition** Pain **Highest recorded phase** 1 **Condition identifier** EFO:0003843 **Subject identifier** D010146 And 56 more, listed on the interactive page. ### Open Targets indications (100) - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000373 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000400 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000474 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000540 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000574 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000771 - **Condition identifier** EFO\_0001365 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003030 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003035 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003047 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004234 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004270 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004272 **Highest recorded phase** 1 - **Condition identifier** EFO\_0006505 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006834 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006911 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007149 And 75 more, listed on the interactive page. ### Open Targets warnings (3) - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States - **Warning** Black Box Warning **Effect** musculoskeletal toxicity **Country** United States - **Warning** Black Box Warning **Effect** neurotoxicity **Country** United States ### Reported adverse events (26) - **Event** anaphylactic reaction **Reports** 787 **Reporting signal score** 1,494.8 - **Event** anaphylactic shock **Reports** 230 **Reporting signal score** 362.357 - **Event** choroiditis **Reports** 42 **Reporting signal score** 152.132 - **Event** contrast media allergy **Reports** 94 **Reporting signal score** 321.899 - **Event** delirium **Reports** 168 **Reporting signal score** 157.882 - **Event** dizziness **Reports** 686 **Reporting signal score** 234.697 - **Event** drug hypersensitivity **Reports** 675 **Reporting signal score** 428.078 - **Event** dyspnoea **Reports** 836 **Reporting signal score** 304.691 - **Event** electrocardiogram qt prolonged **Reports** 293 **Reporting signal score** 375.905 - **Event** erythema **Reports** 295 **Reporting signal score** 131.674 - **Event** hypersensitivity **Reports** 668 **Reporting signal score** 711.772 - **Event** iris transillumination defect **Reports** 46 **Reporting signal score** 228.33 - **Event** mental disorder **Reports** 142 **Reporting signal score** 173.637 - **Event** musculoskeletal injury **Reports** 35 **Reporting signal score** 151.681 - **Event** palpitations **Reports** 234 **Reporting signal score** 146.256 - **Event** paraesthesia **Reports** 279 **Reporting signal score** 138.409 - **Event** pruritus **Reports** 580 **Reporting signal score** 339.587 - **Event** rash **Reports** 1,034 **Reporting signal score** 673.701 - **Event** swelling face **Reports** 193 **Reporting signal score** 154.735 - **Event** tendon disorder **Reports** 68 **Reporting signal score** 130.984 - **Event** tendon pain **Reports** 114 **Reporting signal score** 288.743 - **Event** tendon rupture **Reports** 146 **Reporting signal score** 288.12 - **Event** tendonitis **Reports** 217 **Reporting signal score** 482.838 - **Event** torsade de pointes **Reports** 97 **Reporting signal score** 140.149 - **Event** urticaria **Reports** 577 **Reporting signal score** 510.558 And 1 more, listed on the interactive page. ### Trial references (173) - NCT00082173 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00082173) - NCT00140309 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00140309) - NCT00144417 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00144417) - NCT00164463 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00164463) - NCT00306319 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00306319) - NCT00396084 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00396084) - NCT00460759 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00460759) - NCT00728507 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00728507) - NCT00816426 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00816426) - NCT01055145 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01055145) - NCT01298336 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01298336) - NCT01589497 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01589497) - NCT01674218 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01674218) - NCT01785186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01785186) - NCT01874314 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01874314) - NCT02114684 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02114684) - NCT02193776 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02193776) - NCT02342886 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02342886) - NCT02409290 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02409290) - NCT02410772 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02410772) - NCT02563327 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02563327) - NCT05454345 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05454345) - NCT05766267 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05766267) - NCT00158093 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00158093) - NCT04019652 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04019652) And 148 more, listed on the interactive page. ## Dosing **Dose** 1 drop **Route** Topical ophthalmic **How often** 3 times a day ### Conditions of use - For 7 days ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 83.8 **Calculated partition coefficient (ALogP)** 2.37 **Calculated partition coefficient (XLogP)** 0.6 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 29 **Molecular formula** C21H24FN3O4 **Monoisotopic mass** 401.17508442 **Natural product** No ## Evidence counts **Recorded assays** 5,026 **Active assays** 222 ### Active assay types (2) - Confirmatory - Screening ## Pharmacologic actions - Anti-Bacterial Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000900.html) - Topoisomerase II Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D059005.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** \-0.22 **Mean** \-0.623333 **Minimum** \-2.9 **Maximum** 0.63 **Unit** unitless **Assays** 6 **Standard deviation** 1.29912 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Cardiac potassium channel inhibition **Median** 79,432.8 **Mean** 79,432.8 **Minimum** 79,432.8 **Maximum** 79,432.8 **Unit** nM **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - IC50 #### Solubility **Median** 777 **Mean** 777 **Minimum** 777 **Maximum** 777 **Unit** ug/mL **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - Solubility #### Oral bioavailability **Median** 90 **Mean** 89.5 **Minimum** 86 **Maximum** 92 **Unit** % **Assays** 4 **Standard deviation** 2.51661 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F #### Plasma protein binding **Median** 31 **Mean** 34.36 **Minimum** 19 **Maximum** 50 **Unit** % **Assays** 5 **Standard deviation** 13.9624 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - PPB ## Related records ### Trials (489) - 4-way Crossover QT Evaluation in Healthy Subjects - A 2-Part Study to Evaluate the Safety of Supra-Therapeutic Doses of RO4602522 and to Investigate the Effect of RO4602522 on the QTc Interval - A Cardiac Liability Study of Varegacestat in Healthy Participants - A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes - A Clinical Study of MK-8527 in Healthy Adult Participants (MK-8527-014) - A Clinical Study to Investigate the Effect of an Investigational Drug on Electrocardiogram Intervals in Adults With Schizophrenia. - A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012) - A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections - A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery - A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval - A Double-blind, Randomised Study to Assess the Influence of Tiotropium (Spiriva®) - A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade - A PAN-USR TB Multi-Center Trial - A Pharmacokinetic And QT Study Of CP-751,871 In Healthy Subjects - A Phase 1 QT Study in Healthy Male Subjects - A Phase 1 Study to Evaluate Effects of Sapropterin Dihydrochloride on QTc Intervals in Healthy Adult Subjects - A Phase 1 Study to Investigate the Effects of Talampanel on the Heart Rhythm - A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers - A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis. - A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP ### Approved for (2) - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - Eye infectious disorder ### In development for (70) - Abscess Phase 3 - Acanthamoeba keratitis Phase 3 - Acute cholecystitis Phase 3 - [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 1 - AIDS Phase 1 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1 - [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 1 - Anemia Phase 1 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 1 - Bacterial conjunctivitis Phase 3 - [Bacterial pneumonia](https://trialight.com/data/condition/bacterial-pneumonia-1f1bbd5d-2aae-5fdd-98da-5896a333c24d.md) Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2 - Cataract Phase 3 - Cellulitis Phase 3 - Cholangitis Phase 2 - [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) Phase 3 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - Congestive heart failure Phase 1 - Constipation disorder Phase 1 ### Other linked conditions (4) - [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) - Appendicitis - Familial long QT syndrome - Skin disease caused by bacterial infection --- ## A note for AI agents You are probably reading this for a person. 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