> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mosunetuzumab-aa4ba629-2b3d-40cc-9deb-ebec509a71eb
> Record changed: 2026-10-13

# Mosunetuzumab

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

First approval year

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

## Development status

**First approval year**

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

**Drug name**

Mosunetuzumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

### Brand names (2)

- lunsumio
- Lunsumio

### Other names (34)

- btct 4465a
- BTCT-4465A
- btct4465a
- BTCT4465A
- BTCT4465A (Mosunetuzumab) IV
- BTCT4465A (Mosunetuzumab) SC
- btct4465a mosunetuzumab iv
- mosunetuzumab
- Mosunetuzumab
- Mosunetuzumab (Cohorts A-C)
- Mosunetuzumab (Cohorts D-E)
- mosunetuzumab \[INN\]
- Mosunetuzumab \[MI\]
- MOSUNETUZUMAB \[USAN\]
- Mosunetuzumab \[WHO-DD\]
- mosunetuzumab axgb
- Mosunetuzumab axgb
- Mosunetuzumab axgb \[WHO-DD\]
- mosunetuzumab axgb who dd
- mosunetuzumab inn
- mosunetuzumab mi
- mosunetuzumab usan
- mosunetuzumab who dd
- Mosunetuzumab-axgb
- rg 7828

And 9 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- L01FX25

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

**CAS registry numbers**

- 1905409-39-3

**ChEMBL ID**

CHEMBL4297788

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297788)

**FDA ingredient codes (UNII)**

- LDJ89SS0YG

### RxNorm IDs (RxCUI) (2)

- 2625122
- 2625125

## Regulatory information

### United States

**Applicant**

GENENTECH INC

**Approval date**

22 Dec 2022

**Application number**

BLA761263

### European Union

**Status**

Authorised

**Status date**

3 Jun 2022

**Authorisation date**

3 Jun 2022

**Approved indications**

Lunsumio as monotherapy is indicated for the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) who have received at least two prior systemic therapies.

**Product number**

EMEA/H/C/005680

**Authorisation holder**

Roche Registration GmbH

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

Yes

**Additional monitoring**

Yes

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Lymphoma, Follicular

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/lunsumio)

### Other regulatory facts

**Patents**

0

**Designations**

5

**Earliest recorded loss of exclusivity**

7 Jun 2032

**First in class**

Yes

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

Yes

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

Yes

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

mosunetuzumab

**Type**

Antibody

**Drug name stem**

\-mab; -mab

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action (6)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
CD3e

**Gene symbol**  
CD3E

**Protein identifier**  
P07766
- **Mechanism**  
B-lymphocyte antigen CD20 binding agent

**Action type**  
BINDING\_AGENT

**Target**  
B-lymphocyte antigen CD20

**Protein identifier**  
P11836
- **Mechanism**  
T cell surface glycoprotein CD3 binding agent

**Action type**  
BINDING\_AGENT

**Target**  
T cell surface glycoprotein CD3

**Protein identifier**  
P04234
- **Mechanism**  
T cell surface glycoprotein CD3 binding agent

**Action type**  
BINDING\_AGENT

**Target**  
T cell surface glycoprotein CD3

**Protein identifier**  
P07766
- **Mechanism**  
T cell surface glycoprotein CD3 binding agent

**Action type**  
BINDING\_AGENT

**Target**  
T cell surface glycoprotein CD3

**Protein identifier**  
P09693
- **Action**  
Binding

**Action type**  
Binding

**Target**  
CD20 (membrane-spanning 4-domains, subfamily A, member 1)

**Gene symbol**  
MS4A1

**Protein identifier**  
P11836

### Open Targets mechanisms (2)

- **Mechanism**  
B-lymphocyte antigen CD20 binding agent

**Action type**  
BINDING AGENT

**Target**  
B-lymphocyte antigen CD20
- **Mechanism**  
T cell surface glycoprotein CD3 binding agent

**Action type**  
BINDING AGENT

**Target**  
T cell surface glycoprotein CD3

### Investigated indications (11)

- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D015456
- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Lymphoma, B-Cell, Marginal Zone

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000191

**Subject identifier**  
D018442
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Lymphoma, Non-Hodgkin

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005952

**Subject identifier**  
D008228
- **Condition**  
Lymphoma, B-Cell, Marginal Zone

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000630

**Subject identifier**  
D018442
- **Condition**  
Lymphoma, B-Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001938

**Subject identifier**  
D016393
- **Condition**  
Hematologic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002334

**Subject identifier**  
D019337
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0018906

**Subject identifier**  
D008224

### Open Targets indications (22)

- **Condition identifier**  
EFO\_0000094

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0005952

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002083

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002334
- **Condition identifier**  
MONDO\_0004948

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004967

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005556

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007243

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015759

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0017604

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018876

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018906
- **Condition identifier**  
MONDO\_0018906

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0018908

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019462

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0019465

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0044889

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0100280

**Highest recorded phase**  
2

### Warnings

- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

### Open Targets warnings

- **Warning**  
Black Box Warning

**Effect**  
immune system toxicity

**Country**  
United States

### Reported adverse events (10)

- **Event**  
covid-19

**Reports**  
6

**Reporting signal score**

12.1449
- **Event**  
cytokine release syndrome

**Reports**  
26

**Reporting signal score**

132.525
- **Event**  
disease progression

**Reports**  
16

**Reporting signal score**

37.6049
- **Event**  
follicular lymphoma

**Reports**  
2

**Reporting signal score**

11.8864
- **Event**  
hypogammaglobulinaemia

**Reports**  
3

**Reporting signal score**

9.85264
- **Event**  
immune effector cell-associated neurotoxicity syndrome

**Reports**  
2

**Reporting signal score**

8.59032
- **Event**  
infusion related reaction

**Reports**  
6

**Reporting signal score**

10.2449
- **Event**  
neutropenia

**Reports**  
12

**Reporting signal score**

18.5719
- **Event**  
oral fungal infection

**Reports**  
2

**Reporting signal score**

8.03152
- **Event**  
pneumonitis

**Reports**  
4

**Reporting signal score**

8.53109

### Trial references (24)

- NCT02500407  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02500407)
- NCT05091424  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05091424)
- NCT03671018  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03671018)
- NCT03677141  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03677141)
- NCT04313608  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04313608)
- NCT04970901  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04970901)
- NCT03677154  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03677154)
- NCT04889716  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04889716)
- NCT04246086  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04246086)
- NCT04712097  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04712097)
- NCT04792502  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04792502)
- NCT05169658  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05169658)
- NCT05389293  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05389293)
- NCT05410418  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05410418)
- NCT05849857  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05849857)
- NCT05994235  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05994235)
- NCT06284122  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06284122)
- NCT06337318  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06337318)
- NCT06453044  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06453044)
- NCT05169515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05169515)
- NCT05171647  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05171647)
- NCT05207670  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05207670)
- NCT05260957  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05260957)
- NCT05961696  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05961696)

## Dosing

**Dose**

1 mg

**Route**

Intravenous

**How often**

Every 3 weeks

### Conditions of use

- Administer over a minimum of 4 hours

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (6)

- **Component**  
Disulfide bridge location

**Sequence**  
22-96 $ 22''-96'' $ 23'-94' $ 23'''-87''' $ 133'''-193''' $ 139'-199' $ 146-202 $ 149''-205'' $ 219'-222 $ 213'''-225'' $ 228-231'' $ 231-234'' $ 263-323 $ 266''-326'' $ 369-427 $ 372''-430''
- **Component**  
Sequence: Anti Homo sapiens CD3E Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYIHWVRQAPGQGLEWIGWIYPGDGNTKYNEKFKGRATLTADTSTSTAYLELSSLRSEDTAVYYCARDSYSNYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-94' $ 23'''-87''' $ 133'''-193''' $ 139'-199' $ 146-202 $ 149''-205'' $ 219'-222 $ 213'''-225'' $ 228-231'' $ 231-234'' $ 263-323 $ 266''-326'' $ 369-427 $ 372''-430''
- **Component**  
Sequence: Anti Homo sapiens CD20 Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCRASSSVSYMHWYQQKPGKAPKPLIYAPSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSFNPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Sequence: Anti Homo sapiens CD20 Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYNMHWVRQAPGKGLEWVGAIYPGNGDTSYNQKFKGRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARVVYYSNSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain: (anti-CD3E)

**Type**  
Protein

**Sequence**  
DIVMTQSPDSLAVSLGERATINCKSSQSLLNSRTRKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCTQSFILRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

## National Drug Codes

- 50242-142
- 50242-159
- 50242-177
- 50242-201

## Related records

### Trials (55)

- A Multicenter, Single-Arm, Open-Label, Phase II Trial of Mosunetuzumab in Combination With Tislelizumab for r/r FL
- A Phase 2 Trial of Mosunetuzumab and Zanubrutinib for Patients With Relapsed/Refractory Marginal Zone Lymphoma
- A Phase I Study of Mosunetuzumab for Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
- A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma
- A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL
- A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
- A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma
- A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma
- A Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma
- [A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia](https://trialight.com/data/trial/a-study-evaluating-the-safety-efficacy-and-pharmacokinetics-e717b052-0097-4b5b-b676-a4ce297b8612.md)
- [A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab Monotherapy in Participants With Select B-Cell Malignancies](https://trialight.com/data/trial/a-study-evaluating-the-safety-efficacy-and-pharmacokinetics-8b5fbd88-1e1d-404f-86c9-831d93b53fec.md)
- A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma
- A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma
- A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma
- A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer.
- [A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas](https://trialight.com/data/trial/a-study-to-assess-bms-986458-alone-and-in-combination-with-823872d4-8715-481a-ab2a-e4108a436484.md)
- A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis
- A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP
- [A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-and-anti-cancer-activity-of-d4edad9b-3a59-455e-8286-6a729b1db7e2.md)
- A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

### Approved for (3)

- [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md)
- Neoplasm
- Neoplasm of mature B-cells

### In development for (9)

- B-cell acute lymphoblastic leukemia Phase 1
- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 1
- [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 1
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2
- [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) Phase 1
- MALT lymphoma Phase 2
- [Marginal zone lymphoma](https://trialight.com/data/condition/marginal-zone-lymphoma-e01375fa-199e-506d-9b41-a0427d6844a7.md) Phase 2
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 3
- Richter transformation Phase 2

### Targets (4)

- [CD3D](https://trialight.com/data/target/cd3d-6bee5ce0-96ac-5607-815b-7dbf809d2a64.md) T cell surface glycoprotein CD3 binding agent
- [CD3E](https://trialight.com/data/target/cd3e-b4b887fd-970b-55c2-bf21-d8b729fecbe7.md) T cell surface glycoprotein CD3 binding agent
- [CD3G](https://trialight.com/data/target/cd3g-45960ced-28d6-5e39-be86-e6477c0df8f8.md) T cell surface glycoprotein CD3 binding agent
- [MS4A1](https://trialight.com/data/target/ms4a1-9e34d7a7-7b3d-5f02-928a-d18d9b50c1f8.md) B-lymphocyte antigen CD20 binding agent

---

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