> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mosnodenvir-5b06a242-d5c4-407d-9282-3ca833517ccc
> Record changed: 2026-10-13

# Mosnodenvir

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

**Drug name**

Mosnodenvir

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

**Molecular weight**

582.98

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

**Structure (SMILES)**

COc1cc(N\[C@H\](C(=O)c2c\[nH\]c3ccc(OC(F)(F)F)cc23)c2ccc(Cl)cc2OC)cc(S(C)(=O)=O)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

### Other names (13)

- jnj 1802
- jnj 64281802
- JNJ-1802
- Jnj-64281802
- JNJ-64281802
- mosnodenvir
- Mosnodenvir
- mosnodenvir \[INN\]
- MOSNODENVIR \[USAN\]
- Mosnodenvir \[WHO-DD\]
- mosnodenvir inn
- mosnodenvir usan
- mosnodenvir who dd

## Identifiers

**CAS registry numbers**

- 2043343-94-6

**ChEMBL ID**

CHEMBL5314530

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

**InChIKey**

QNOPDDHSGQQLCV-DEOSSOPVSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314530)

**PubChem compound IDs**

- 133083036

**FDA ingredient codes (UNII)**

- 5EJO0RJF9O

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-denvir; -vir

### Investigated indications (3)

- **Condition**  
Virus Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000763

**Subject identifier**  
D014777
- **Condition**  
Severe Dengue

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004227

**Subject identifier**  
D019595
- **Condition**  
Dengue

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005547

**Subject identifier**  
D003715

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0000763
- **Condition identifier**  
EFO\_0005547

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005108
- **Condition identifier**  
MONDO\_0005502

**Highest recorded phase**  
2

### Trial references (2)

- NCT04906980  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04906980)
- NCT05201794  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05201794)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

2

**Polar surface area**

106.72

**Calculated partition coefficient (ALogP)**

6.18

**Calculated partition coefficient (XLogP)**

6.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

9

**Heavy atoms**

39

**Molecular formula**

C26H22ClF3N2O6S

**Monoisotopic mass**

582.0839198

**Natural product**

No

## Evidence counts

**Recorded assays**

65

**Active assays**

11

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (4)

- A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants
- [A Study of JNJ-64281802 for the Prevention of Dengue Infection](https://trialight.com/data/trial/a-study-of-jnj-64281802-for-the-prevention-of-dengue-e8434ed4-9db5-46ac-bb68-1f49f50d0c63.md)
- A Study of JNJ-64281802 in Healthy Adult Participants
- A Study of JNJ-64281802 in Participants With Confirmed Dengue Fever

### In development for (3)

- [Dengue disease](https://trialight.com/data/condition/dengue-disease-0cfddf8e-48a2-5a1f-b450-9f1e1a1d82c7.md) Phase 2
- Dengue hemorrhagic fever Phase 2
- [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 2

---

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