> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/monalizumab-8cc332ab-4a5a-46a1-93d5-ad31573af1d4
> Record changed: 2026-10-13

# Monalizumab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

**Drug name**

Monalizumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

### Other names (35)

- anti nkg2a
- Anti-NKG2A
- durvalumab monalizumab
- humz270
- HUMZ270
- immunoglobulin g4 anti human nkg2a cd94 receptor human mouse monoclonal humz270 heavy chain disulfide with human mouse monoclonal humz270 light chain dimer
- immunoglobulin g4 kappa anti homo sapiens klrc1 killer cell lectin like receptor subfamily c member 1 nkg2 a nkg2a cd159a cd94 humanized monoclonal antibody gamma4 heavy chain 1 452 humanized vh homo sapiens ighv1 18 01 89 80 ighd ighj2 01 r120 q 117 l123 t 130 8 8 18 1 125 ighg4 01 ch1 126 223 hinge s10 p 233 224 235 ch2 236 345 ch3 346 450 chs 451 452 126 452 139 214 disulfide with kappa light chain 1 214 humanized v kappa homo sapiens igkv1 39 01 87 40 igkj4 01 6 3 9 1 107 homo sapiens igkc 01 km3 108 214 dimer 231 231 234 234 bisdisulfide
- Immunoglobulin G4-kappa, anti-\[Homo sapiens KLRC1 (killer cell lectin-like receptor subfamily C member 1, NKG2-A, NKG2A, CD159a, CD94)\], humanized monoclonal antibody; gamma4 heavy chain (1-452) \[humanized VH (Homo sapiens IGHV1-18\*01 (89.80%)-(IGHD)-IGHJ2\*01 R120>Q(117), L123>T(130))\[8.8.18\](1-125)), IGHG4\*01 (CH1 (126-223), hinge S10>P (233) (224-235), CH2 (236-345), CH3 (346-450), CHS (451-452))(126-452)\],(139-214’)-disulfide with kappa light chain (1’-214’) \[humanized V-KAPPA (Homo sapiens IGKV1-39\*01 (87.40%) – IGKJ4\*01) \[6.3.9\] (1’-107’)-Homo sapiens IGKC\*01, Km3 (108’-214’)\]; dimer (231-231’’: 234-234’’)-bisdisulfide
- Immunoglobulin G4, anti-(human NKG2A/CD94 receptor) (human-mouse monoclonal humZ270 heavy chain), disulfide with human-mouse monoclonal humZ270 light chain, dimer
- iph 2201
- iph 2201 anti nkg2a
- Iph-2201
- IPH-2201 (ANTI-NKG2A)
- iph2201
- Iph2201
- IPH2201
- monalizumab
- Monalizumab
- Monalizumab (IPH2201)
- monalizumab \[INN\]
- MONALIZUMAB \[USAN\]
- Monalizumab \[WHO-DD\]
- monalizumab inn
- monalizumab usan
- monalizumab who dd

And 10 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1228763-95-8

**ChEMBL ID**

CHEMBL4297787

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297787)

**FDA ingredient codes (UNII)**

- 3ZXZ2V0588

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

monalizumab

**Type**

Antibody

**Drug name stem**

\-mab; -mab

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
killer cell lectin like receptor C1 (CD159a)

**Gene symbol**  
KLRC1

**Protein identifier**  
P26715

**Median affinity**

10.57

**Affinity units**  
pKd

**Primary target**  
Yes
- **Mechanism**  
NKG2-A/NKG2-B type II integral membrane protein inhibitor

**Action type**  
Inhibitor

**Target**  
NKG2-A/NKG2-B type II integral membrane protein

**Protein identifier**  
P26715

### Open Targets mechanisms

- **Mechanism**  
NKG2-A/NKG2-B type II integral membrane protein inhibitor

**Action type**  
Inhibitor

**Target**  
NKG2-A/NKG2-B type II integral membrane protein

### Investigated indications (13)

- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Squamous Cell Carcinoma of Head and Neck

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000199

**Subject identifier**  
D000077195
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000707

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Head and Neck Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004284

**Subject identifier**  
D006258
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Genital Neoplasms, Female

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0021148

**Subject identifier**  
D005833
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (28)

- **Condition identifier**  
EFO\_0000095
- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000199
- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0006859
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004948

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004958

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005028

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005580

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005627

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0011962

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018874

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018881

**Highest recorded phase**  
2

And 3 more, listed on the interactive page.

### Trial references (18)

- NCT02331875  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02331875)
- NCT02459301  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02459301)
- NCT02557516  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02557516)
- NCT02643550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02643550)
- NCT02671435  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02671435)
- NCT04333914  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04333914)
- NCT02921685  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02921685)
- NCT03088059  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03088059)
- NCT03794544  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03794544)
- NCT03801902  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03801902)
- NCT03822351  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03822351)
- NCT03833440  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03833440)
- NCT05061550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05061550)
- NCT05221840  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05221840)
- NCT04145193  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04145193)
- NCT04307329  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04307329)
- NCT04590963  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04590963)
- NCT05903092  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05903092)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (24)

- A Dose-Ranging Study of IPH2201 in Patients With Gynecologic Malignancies
- [A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-global-study-to-assess-the-effects-of-durvalumab-with-9b1ffaa8-7388-46c3-8f09-9f534f48bdb9.md)
- A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
- A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer
- Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation
- Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer
- Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced Esoph and Gastro-esoph Jction CA
- Biomarker-based Study in R/M SCCHN
- Combination Study of IPH2201 (Monalizumab) With Ibrutinib in Relapsed, Refractory or Previously Untreated CLL
- Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC
- Efficacy Study of Pre-operative IPH2201 in Patients With Squamous Cell Carcinoma of the Oral Cavity
- Monalizumab and MEDI5752 in Patients With MSI and/or dMMR Metastatic Cancer
- Monalizumab and Trastuzumab In Metastatic HER2-pOSitive breAst Cancer: MIMOSA-trial
- MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer
- [Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-treatment-in-resectable-non-small-c5704130-e063-4bfd-817c-edc38351eb37.md)
- Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer
- Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC
- Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance
- Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection
- Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation

### In development for (14)

- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 1
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- Female reproductive system neoplasm Phase 1
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 3
- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- Oral cavity squamous cell carcinoma Phase 1
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 2
- [Squamous cell carcinoma](https://trialight.com/data/condition/squamous-cell-carcinoma-44944de3-3c1f-5714-9da2-a28db7d896c2.md) Phase 3
- Upper aerodigestive tract neoplasm Phase 1

### Other linked conditions (1)

- [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md)

### Targets (1)

- [KLRC1](https://trialight.com/data/target/klrc1-a6a0a416-e9cb-5950-bbca-aa636c7cea21.md) NKG2-A/NKG2-B type II integral membrane protein inhibitor

---

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