> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/mometasone-furoate-2d212820-01d7-46aa-a20e-8d1991b493f4 > Record changed: 2026-10-13 # Mometasone furoate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) First approval year 1987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) ## Development status **First approval year** 1987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **Drug name** Mometasone furoate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **Molecular weight** 521.44 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **Structure (SMILES)** C\[C@@H\]1C\[C@H\]2\[C@@H\]3CCC4=CC(=O)C=C\[C@\]4(C)\[C@@\]3(Cl)\[C@@H\](O)C\[C@\]2(C)\[C@@\]1(OC(=O)c1ccco1)C(=O)CCl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) ### Brand names (22) - asmanex - Asmanex - asmanex hfa - Asmanex hfa - asmanex twisthaler - Asmanex twisthaler - elocon - Elocon - mometasone furoate - Mometasone furoate - mometasone furoate component of dulera - Mometasone furoate component of dulera - mometasone furoate component of lyr 220 active - Mometasone furoate component of lyr-220 active - mometasone furoate component of ryaltris - Mometasone furoate component of ryaltris - nasonex - Nasonex - nasonex 24hr allergy - Nasonex 24hr allergy - sinuva - Sinuva ### Other names (70) - (11.BETA.,16.ALPHA.)-9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE - 11 beta 16 alpha 9 21 dichloro 17 2 furanylcarbonyl oxy 11 hydroxy 16 methylpregna 1 4 diene 3 20 dione - 9 21 dichloro 11β 17 dihydroxy 16α methylpregna 1 4 diene 3 20 dione 17 2 furoate - 9,21-Dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-(2-furoate) - dulera component mometasone furoate - DULERA COMPONENT MOMETASONE FUROATE - elocon - Elocon - Elocon ointment - las 41002 - LAS-41002 - las41002 - LAS41002 - lyr 210 - lyr 220 active component mometasone furoate - Lyr-210 - LYR-210 - LYR-220 ACTIVE COMPONENT MOMETASONE FUROATE - lyr210 - LYR210 - mometasone furoate - Mometasone furoate - Mometasone Furoate - MOMETASONE FUROATE - Mometasone Furoate (MF) And 45 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 83919-23-7 **ChEMBL ID** CHEMBL1161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **InChIKey** WOFMFGQZHJDGCX-ZULDAHANSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) **PubChem compound IDs** - 441336 **FDA ingredient codes (UNII)** - 04201GDN4R ### ATC classification codes (4) - D07AC13 - D07XC03 - R01AD09 - R03BA07 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1161) ### RxNorm IDs (RxCUI) (2) - 30145 - 108118 ## Regulatory information ### United States **Applicant** ORGANON LLC **Approval date** 30 Mar 2005 **Application number** NDA021067 ### Other regulatory facts **Patents** 7 **Designations** 1 **Earliest recorded loss of exclusivity** 24 Nov 2034 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Over the counter ## Pharmacology ### Drug classification #### Administration routes - Parenteral - topical ### Mechanisms of action - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor **Protein identifier** P04150 ### Open Targets mechanisms - **Mechanism** Glucocorticoid receptor agonist **Action type** Agonist **Target** Glucocorticoid receptor ### DrugCentral mechanisms - **Action type** Agonist **Gene symbol** NR3C1 **Protein identifier** P04150 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (27) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Psoriasis **Highest recorded phase** 2 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Skin Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Hypertrophy **Highest recorded phase** 3 **Condition identifier** EFO:0002460 **Subject identifier** D006984 - **Condition** Sleep Apnea, Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0003918 **Subject identifier** D020181 - **Condition** Rhinitis, Allergic, Seasonal **Highest recorded phase** 4 **Condition identifier** EFO:0003956 **Subject identifier** D006255 - **Condition** Alopecia Areata **Highest recorded phase** 0.5 **Condition identifier** EFO:0004192 **Subject identifier** D000506 - **Condition** Eosinophilic Esophagitis **Highest recorded phase** 2 **Condition identifier** EFO:0004232 **Subject identifier** D057765 - **Condition** Rhinitis, Allergic, Seasonal **Highest recorded phase** 4 **Condition identifier** EFO:0005854 **Subject identifier** D006255 - **Condition** Rhinitis, Allergic **Highest recorded phase** 4 **Condition identifier** EFO:0005854 **Subject identifier** D065631 - **Condition** Pemphigoid, Bullous **Highest recorded phase** 2 **Condition identifier** EFO:0007187 **Subject identifier** D010391 - **Condition** Otitis Media with Effusion **Highest recorded phase** 0.5 **Condition identifier** EFO:0007415 **Subject identifier** D010034 - **Condition** Sinusitis **Highest recorded phase** 3 **Condition identifier** EFO:0007486 **Subject identifier** D012852 - **Condition** Nasal Polyps **Highest recorded phase** 4 **Condition identifier** EFO:1000391 **Subject identifier** D009298 - **Condition** Rhinitis, Allergic, Perennial **Highest recorded phase** 3 **Condition identifier** EFO:1001417 **Subject identifier** D012221 - **Condition** Psoriasis **Highest recorded phase** 2 **Condition identifier** EFO:1001494 **Subject identifier** D011565 - **Condition** Nasal Obstruction **Highest recorded phase** 4 **Condition identifier** HP:0001742 **Subject identifier** D015508 - **Condition** Lung Diseases, Obstructive **Highest recorded phase** 4 **Condition identifier** HP:0006536 **Subject identifier** D008173 - **Condition** Nasal Polyps **Highest recorded phase** 4 **Condition identifier** HP:0100582 **Subject identifier** D009298 - **Condition** Asthma **Highest recorded phase** 4 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Hypersensitivity **Highest recorded phase** 1 **Condition identifier** MONDO:0005271 **Subject identifier** D006967 - **Condition** Breast Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Anemia, Sickle Cell **Highest recorded phase** 2 **Condition identifier** MONDO:0011382 **Subject identifier** D000755 - **Condition** Radiodermatitis **Highest recorded phase** 2 **Condition identifier** MONDO:0043771 **Subject identifier** D011855 And 2 more, listed on the interactive page. ### Open Targets indications (54) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000701 - **Condition identifier** EFO\_0002460 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003918 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003956 - **Condition identifier** EFO\_0003963 - **Condition identifier** EFO\_0004192 - **Condition identifier** EFO\_0004232 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005854 - **Condition identifier** EFO\_0007187 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007415 - **Condition identifier** EFO\_0007486 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009364 - **Condition identifier** EFO\_0009837 - **Condition identifier** EFO\_1000391 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001417 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001494 **Highest recorded phase** 2 - **Condition identifier** EFO\_1002029 **Highest recorded phase** 3 - **Condition identifier** HP\_0000458 **Highest recorded phase** 3 - **Condition identifier** HP\_0000689 - **Condition identifier** HP\_0000964 **Highest recorded phase** 2 - **Condition identifier** HP\_0001742 - **Condition identifier** HP\_0001742 **Highest recorded phase** 4 - **Condition identifier** HP\_0002091 **Highest recorded phase** 1 And 29 more, listed on the interactive page. ### Reported adverse events (41) - **Event** adrenal suppression **Reports** 29 **Reporting signal score** 88.0686 - **Event** anosmia **Reports** 63 **Reporting signal score** 138.781 - **Event** asthma **Reports** 486 **Reporting signal score** 896.2 - **Event** asthma-chronic obstructive pulmonary disease overlap syndrome **Reports** 20 **Reporting signal score** 79.2309 - **Event** blood count abnormal **Reports** 65 **Reporting signal score** 81.3107 - **Event** chest discomfort **Reports** 219 **Reporting signal score** 203.674 - **Event** coma **Reports** 183 **Reporting signal score** 232.823 - **Event** cough **Reports** 618 **Reporting signal score** 666.198 - **Event** cushing's syndrome **Reports** 46 **Reporting signal score** 89.4701 - **Event** diarrhoea **Reports** 41 **Reporting signal score** 125.406 - **Event** dysphonia **Reports** 147 **Reporting signal score** 176.657 - **Event** dyspnoea **Reports** 1,171 **Reporting signal score** 1,142.62 - **Event** gastrooesophageal reflux disease **Reports** 293 **Reporting signal score** 465.463 - **Event** incorrect dose administered by product **Reports** 27 **Reporting signal score** 99.525 - **Event** injection site pain **Reports** 2 **Reporting signal score** 79.9229 - **Event** nasal congestion **Reports** 153 **Reporting signal score** 201.326 - **Event** nasal discomfort **Reports** 48 **Reporting signal score** 112.983 - **Event** nasal polyps **Reports** 52 **Reporting signal score** 161.452 - **Event** pneumonia aspiration **Reports** 176 **Reporting signal score** 357.057 - **Event** polycystic ovaries **Reports** 26 **Reporting signal score** 78.2679 - **Event** poor quality device used **Reports** 1,604 **Reporting signal score** 8,503.71 - **Event** poor quality drug administered **Reports** 68 **Reporting signal score** 169.903 - **Event** poor quality product administered **Reports** 79 **Reporting signal score** 250.766 - **Event** product availability issue **Reports** 46 **Reporting signal score** 111.741 - **Event** product dose omission issue **Reports** 322 **Reporting signal score** 534.113 And 16 more, listed on the interactive page. ### Trial references (124) - NCT00224523 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00224523) - NCT00720382 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00720382) - NCT00732368 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00732368) - NCT00779545 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00779545) - NCT00779740 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00779740) - NCT01135134 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01135134) - NCT01165424 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01165424) - NCT01287364 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01287364) - NCT01470053 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01470053) - NCT01700192 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01700192) - NCT02498509 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02498509) - NCT00358527 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00358527) - NCT00453063 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00453063) - NCT00468312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00468312) - NCT00491504 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00491504) - NCT00552110 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00552110) - NCT00784732 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00784732) - NCT01038427 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01038427) - NCT01523236 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01523236) - NCT01673659 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01673659) - NCT01850823 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01850823) - NCT02125253 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02125253) - NCT02318303 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02318303) - NCT02478398 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02478398) - NCT02557269 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02557269) And 99 more, listed on the interactive page. ## Dosing **Route** Topical **How often** Once daily ### Conditions of use (3) - Apply a thin film to the affected skin areas - Discontinue when control is achieved - Do not use with occlusive dressings unless directed by a physician ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 1 **Polar surface area** 93.81 **Calculated partition coefficient (ALogP)** 4.87 **Calculated partition coefficient (XLogP)** 3.9 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 4 **Heavy atoms** 35 **Molecular formula** C27H30Cl2O6 **Monoisotopic mass** 520.1419441 **Natural product** Yes ## National Drug Codes - 0713-0634 - 0713-0635 - 10599-003 - 13668-527 - 21922-071 - 21922-072 - 45802-118 - 45802-119 - 45802-257 - 63187-288 - 63187-432 - 65162-891 - 68462-192 - 68462-385 - 71205-413 - 78206-111 - 78206-112 - 78206-113 - 78206-114 - 78206-115 - 78206-125 - 78206-126 - 78206-127 - 85766-181 - 50090-1633 And 17 more, listed on the interactive page. ## Evidence counts **Recorded assays** 1,275 **Active assays** 183 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Anti-Inflammatory Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html) - Dermatologic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html) - Anti-Allergic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018926.html) ## Related records ### Trials (201) - 4"S" - Seasonal Symptoms Suppression Study - 480 Biomedical Sinus Drug Depot - A Bioavailability Study of DFD-03 Compared to Tazorac® in Patients With Moderate Acne Vulgaris - A Clinical Safety and Efficacy Comparison of NEVANAC 0.1% to Vehicle After Cataract Surgery in Diabetic Retinopathy Patients - A Clinical Trial About Treatment of Mild to Moderate Persistent Alergic Rhinnitis With Test or Reference Mometasone (PUMA) - A Clinical Trial to Evaluate the Corneal Endothelial Health of DED Subjects Treated With Cyclosporine - A Cohort Study on Biomarkers to Predict the Efficacy of Biologics for Chronic Rhinosinusitis with Nasal Polyps - A Comparison of Mometasone Furoate DPI Versus Budesonide DPI in Budesonide DPI in Asthmatics (Study P04880) - A Comparison of Mometasone Nasal Spray, Nasonex Nasal Spray, Nasonex Nasal Spray Suspension, & Placebo for Treatment of Seasonal Allergies for Safety, Efficacy, & Superiority in 1520 Male & Female Volunteers - A Comparison of Patients on AVAMYS ® Versus NASONEX (A Trade Mark of Schering Corporation) and FLIXONASE ® on Key Health Outcome Measures - A Controlled Clinical Study of Dupilumab in Patients With Bilateral Nasal Polyps - A Long-term Study of Mometasone Furoate in Patients With Perennial Allergic Rhinitis (Study P04459) - A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Participants With Asthma - A Multicenter, Randomized, Double-blind, Three-arm, Parallel Clinical Endpoint Bioequivalence Study of Monometasone Furoate Nasal Spray in Patients With Seasonal Allergic Rhinitis - A Patient Handling Study of Mometasone Furoate/Formortoral Fumarate (MF/F) Metered Dose Inhaler (MDI) With an Integrated Dose Counter in Adolescent and Adult Subjects With Asthma or Chronic Obstructive Pulmonary Disease (Study P04703AM1) - A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps - A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps - A Phase I Study to Assess Novel Cream in a Psoriasis Plaque Test - A Phase I Study to Assess Novel Ointment in a Psoriasis Plaque Test - A Phase I Study to Assess the Safety and Tolerability of Topical CRx-197 Formulations in Healthy Volunteers ### Approved for (6) - [Allergic rhinitis](https://trialight.com/data/condition/allergic-rhinitis-5900f04b-c465-5b16-bbb0-e03e4c2cbdfc.md) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) - Nasal cavity polyp - Obstructive lung disease - [Seasonal allergic rhinitis](https://trialight.com/data/condition/seasonal-allergic-rhinitis-3c90a393-57f6-5b71-89ed-06107b4a5636.md) - [Skin disorder](https://trialight.com/data/condition/skin-disorder-c8e27943-0efd-5c2b-abce-01c2ef37e853.md) ### In development for (17) - Allergic disease Phase 1 - [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Early phase 1 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3 - Bullous pemphigoid Phase 2 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - Eosinophilic esophagitis Phase 2 - [Obstructive sleep apnea syndrome](https://trialight.com/data/condition/obstructive-sleep-apnea-syndrome-02928491-a2d7-50f4-a4b7-30b79e6771ff.md) Phase 3 - Otitis media with effusion Early phase 1 - Palmoplantar pustulosis Phase 2 - Perennial allergic rhinitis Phase 3 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 2 - Radiodermatitis Phase 2 - Sickle cell disease Phase 2 - Sinusitis Phase 3 - Spinal cord injury Phase 1 ### Targets (1) - [NR3C1](https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532.md) Glucocorticoid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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