> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/molnupiravir-add1d7d0-61b9-41a9-b598-946786e8b41e > Record changed: 2026-10-13 # Molnupiravir Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) **Drug name** Molnupiravir Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) **Molecular weight** 329.31 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) **Structure (SMILES)** CC(C)C(=O)OC\[C@H\]1O\[C@@H\](n2cc/c(=N\\O)\[nH\]c2=O)\[C@H\](O)\[C@@H\]1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) ### Other names (24) - .BETA.-D-N4 HYDROXYCYTIDINE-5'-ISOPROPYL ESTER - beta d n4 hydroxycytidine 5 isopropyl ester - eidd 1931 isopropyl ester - Eidd 1931-isopropyl ester - eidd 2801 - EIDD-1931 ISOPROPYL ESTER - Eidd-2801 - EIDD-2801 - mk 4482 - MK-4482 - molnupiravir - Molnupiravir - Molnupiravir (Esperavir) - molnupiravir \[INN\] - MOLNUPIRAVIR \[JAN\] - MOLNUPIRAVIR \[USAN\] - Molnupiravir \[WHO-DD\] - Molnupiravir 200 mg - Molnupiravir 400 mg - Molnupiravir 800 mg - molnupiravir inn - molnupiravir jan - molnupiravir usan - molnupiravir who dd ## Identifiers **CAS registry numbers** - 2492423-29-5 **ChEMBL ID** CHEMBL4650320 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) **InChIKey** HTNPEHXGEKVIHG-QCNRFFRDSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) **PubChem compound IDs** - 145996610 **RxNorm IDs (RxCUI)** - 2587901 **FDA ingredient codes (UNII)** - YA84KI1VEW ### ATC classification codes (2) - J05A - J05AB18 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650320) ## Regulatory information ### European Union **Status** application\_withdrawn **Status date** 21 Jun 2023 **Approved indications** Treatment of coronavirus disease 2019 (COVID-19). **Product number** EMEA/H/C/005789 **Authorisation holder** Merck Sharp & Dohme B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - COVID-19 virus infection European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/lagevrio) ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** molnupiravir **Type** Synthetic organic **Drug name stem** \-vir; -vir **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action - **Mechanism** RNA disrupting agent **Action type** DISRUPTING\_AGENT **Target** RNA ### Investigated indications (8) - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Virus Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Kidney Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0003086 **Subject identifier** D007674 - **Condition** Influenza, Human **Highest recorded phase** 2 **Condition identifier** EFO:0007328 **Subject identifier** D007251 - **Condition** Respiratory Syncytial Virus Infections **Highest recorded phase** 2 **Condition identifier** EFO:1001413 **Subject identifier** D018357 - **Condition** COVID-19 **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (10) - **Condition identifier** EFO\_0000763 - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 1 - **Condition identifier** EFO\_1001413 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001577 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005108 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005502 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005812 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100163 **Highest recorded phase** 3 ### Reported adverse events - **Event** torsade de pointes **Reports** 2 **Reporting signal score** 12.1107 ### Trial references (17) - NCT04381936 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04381936) - NCT04730206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04730206) - NCT04392219 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04392219) - NCT04405570 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04405570) - NCT04405739 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04405739) - NCT04575584 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04575584) - NCT04575597 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04575597) - NCT04746183 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04746183) - NCT04939428 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04939428) - NCT05041907 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05041907) - NCT05459532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05459532) - NCT05595824 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05595824) - NCT05386589 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05386589) - NCT05386758 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05386758) - NCT05559905 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05559905) - NCT05648448 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05648448) - NCT05818124 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05818124) ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 4 **Polar surface area** 146.37 **Calculated partition coefficient (ALogP)** \-1.72 **Calculated partition coefficient (XLogP)** \-0.8 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 23 **Molecular formula** C13H19N3O7 **Monoisotopic mass** 329.12229995 **Natural product** No ## Evidence counts **Recorded assays** 47 **Active assays** 17 ### Active assay types - Confirmatory ## Pharmacologic actions - Antiviral Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000998.html) ## Related records ### Trials (27) - A Clinical Study of MK-4482 in Chinese Healthy Male Participants (MK-4482-009) - [A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)](https://trialight.com/data/trial/a-clinical-study-of-molnupiravir-to-prevent-severe-illness-d0c10a29-b369-439f-9083-3e5d4b36772c.md) - A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza - A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa - A Study to Evaluate Molnupiravir (MK-4482; MOV) in Participants With Severe Renal Impairment (MK-4482-003) - A Study to Evaluate Molnupiravir (MK-4482) in Participants With Moderate Hepatic Impairment (MK-4482-016) - A Study to Evaluate Molnupiravir Tablet Formulation Compared to the Molnupiravir Capsule Formulation in Healthy Adult Participants (MK-4482-011) - Adaptive Dengue Antiviral Platform Trial - AGILE (Early Phase Platform Trial for COVID-19) - Assessing Antiviral Treatments in Early Symptomatic RSV - COVID-19 First In Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of EIDD-2801 in Healthy Volunteers - Effectiveness and Safety of New Oral Antivirals for COVID-19 - Efficacy and Safety of Molnupiravir (MK-4482) in Hospitalized Adult Participants With COVID-19 (MK-4482-001) - Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19 (MK-4482-002) - [Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated With Experimental Influenza Virus (MK-4482-019)](https://trialight.com/data/trial/efficacy-and-safety-of-molnupiravir-in-healthy-participants-de76c09f-4fdc-4b77-83ca-82bd0015d18e.md) - Evaluation of the Efficacy and Safety of Molnupiravir Treatment in Mild/Moderate Covid-19 Patients. - Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV) - Molnupiravir and COVID-19 Mortality Reduction in the Omicron Era - Open Multicenter Study for Assessment of Efficacy and Safety of Molnupiravir in Adult Patients With COVID-19 - Pharmacokinetics and Bioequivalence of Molnupiravir, 200 mg Capsules and Lagevrio, 200 mg Capsules in Healthy Volunteers ### In development for (7) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 2 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 - [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md) Phase 2 - [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 3 - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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