> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/mogamulizumab-6ae2dd49-0d90-4a83-98c9-7c3fd570a211 > Record changed: 2026-10-13 # Mogamulizumab Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) First approval year 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) ## Development status **First approval year** 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) **Drug name** Mogamulizumab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) ### Brand names (2) - poteligeo - Poteligeo ### Other names (40) - amg 761 - AMG 761 - AMG-761 - immunoglobulin g1 anti cc chemokine receptor ccr4 human mouse monoclonal kw 0761 heavy chain disulfide with human mouse monoclonal kw 0761 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(CC CHEMOKINE RECEPTOR CCR4) (HUMAN-MOUSE MONOCLONAL KW-0761 HEAVY CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL KW-0761 .KAPPA.-CHAIN, DIMER - km 8761 - KM-8761 - km8761 - KM8761 - kw 0761 - KW-0761 - KW-0761 (mogamulizumab) - mogamulizumab - Mogamulizumab - Mogamulizumab (genetical recombination) - MOGAMULIZUMAB (GENETICAL RECOMBINATION) \[JAN\] - Mogamulizumab (KW-0761) - Mogamulizumab (subsequent cycles post TSEB) - mogamulizumab \[INN\] - MOGAMULIZUMAB \[JAN\] - MOGAMULIZUMAB \[MI\] - MOGAMULIZUMAB \[USAN\] - Mogamulizumab \[WHO-DD\] - mogamulizumab genetical recombination - mogamulizumab genetical recombination jan And 15 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1159266-37-1 **ChEMBL ID** CHEMBL1743041 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) **FDA ingredient codes (UNII)** - YI437801BE ### ATC classification codes (2) - L01FX09 - L01XC25 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1743041) ### RxNorm IDs (RxCUI) (2) - 2054068 - 2054077 ## Regulatory information ### United States **Applicant** KYOWA KIRIN **Approval date** 8 Aug 2018 **Application number** BLA761051 ### European Union **Status** Authorised **Status date** 22 Nov 2018 **Authorisation date** 22 Nov 2018 **Approved indications** Poteligeo is indicated for the treatment of adult patients with mycosis fungoides (MF) or Sézary syndrome (SS) who have received at least one prior systemic therapy. **Product number** EMEA/H/C/004232 **Authorisation holder** Kyowa Kirin Holdings B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Mycosis Fungoides - Sezary Syndrome European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/poteligeo) ### Other regulatory facts **Patents** 0 **Designations** 5 **Earliest recorded loss of exclusivity** 26 Nov 2028 **First in class** Yes **Fast track** No **Breakthrough designation** Yes **Orphan designation** Yes **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** mogamulizumab **Type** Antibody **Drug name stem** \-mab; -mab **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (2) - **Mechanism** C-C chemokine receptor type 4 cross-linking agent **Action type** CROSS\_LINKING\_AGENT **Target** C-C chemokine receptor type 4 **Protein identifier** P51679 - **Action** Inhibition **Action type** Inhibitor **Target** CCR4 **Gene symbol** CCR4 **Protein identifier** P51679 **Primary target** Yes ### Open Targets mechanisms - **Mechanism** C-C chemokine receptor type 4 cross-linking agent **Action type** CROSS-LINKING AGENT **Target** C-C chemokine receptor type 4 ### Investigated indications (12) - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 1 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Carcinoma **Highest recorded phase** 1 **Condition identifier** EFO:0000313 **Subject identifier** D002277 - **Condition** Lymphoma **Highest recorded phase** 2 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 4 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Lymphoma, T-Cell, Cutaneous **Highest recorded phase** 3 **Condition identifier** EFO:0002913 **Subject identifier** D016410 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 1 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Paraparesis, Tropical Spastic **Highest recorded phase** 3 **Condition identifier** EFO:0007527 **Subject identifier** D015493 - **Condition** Sezary Syndrome **Highest recorded phase** 4 **Condition identifier** EFO:1000785 **Subject identifier** D012751 - **Condition** Mycosis Fungoides **Highest recorded phase** 4 **Condition identifier** EFO:1001051 **Subject identifier** D009182 - **Condition** Lymphoma, T-Cell, Peripheral **Highest recorded phase** 2 **Condition identifier** MONDO:0000430 **Subject identifier** D016411 - **Condition** Asthma **Highest recorded phase** 1 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Leukemia-Lymphoma, Adult T-Cell **Highest recorded phase** 2 **Condition identifier** MONDO:0019471 **Subject identifier** D015459 ### Open Targets indications (21) - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0002913 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007527 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000785 - **Condition identifier** EFO\_1001051 - **Condition identifier** MONDO\_0000430 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000607 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002367 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007576 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008039 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008903 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0009691 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0017844 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0018905 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0019471 - **Condition identifier** MONDO\_0019471 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0023644 **Highest recorded phase** 1 ### Reported adverse events (29) - **Event** autoimmune dermatitis **Reports** 2 **Reporting signal score** 10.0395 - **Event** autoimmune hepatitis **Reports** 6 **Reporting signal score** 11.8374 - **Event** chills **Reports** 19 **Reporting signal score** 16.1712 - **Event** cutaneous t-cell lymphoma recurrent **Reports** 3 **Reporting signal score** 19.7754 - **Event** cytomegalovirus viraemia **Reports** 6 **Reporting signal score** 15.5655 - **Event** diffuse large b-cell lymphoma **Reports** 10 **Reporting signal score** 28.046 - **Event** disease progression **Reports** 63 **Reporting signal score** 125.111 - **Event** epstein-barr virus associated lymphoma **Reports** 5 **Reporting signal score** 22.5003 - **Event** epstein-barr virus infection **Reports** 6 **Reporting signal score** 12.9228 - **Event** erythema **Reports** 26 **Reporting signal score** 21.667 - **Event** graft versus host disease **Reports** 10 **Reporting signal score** 27.7642 - **Event** graft versus host disease in eye **Reports** 3 **Reporting signal score** 14.2347 - **Event** graft versus host disease in gastrointestinal tract **Reports** 4 **Reporting signal score** 11.8691 - **Event** graft versus host disease in skin **Reports** 6 **Reporting signal score** 18.7163 - **Event** headache **Reports** 3 **Reporting signal score** 8.90798 - **Event** hepatic cytolysis **Reports** 5 **Reporting signal score** 12.3784 - **Event** infusion related reaction **Reports** 30 **Reporting signal score** 47.9265 - **Event** lymphopenia **Reports** 14 **Reporting signal score** 27.7501 - **Event** mycobacterium chelonae infection **Reports** 6 **Reporting signal score** 26.5276 - **Event** peripheral t-cell lymphoma unspecified stage iii **Reports** 5 **Reporting signal score** 37.7298 - **Event** pruritus **Reports** 28 **Reporting signal score** 14.4792 - **Event** rash **Reports** 94 **Reporting signal score** 105.611 - **Event** skin disorder **Reports** 12 **Reporting signal score** 21.069 - **Event** skin lesion **Reports** 11 **Reporting signal score** 16.8567 - **Event** suspected covid-19 **Reports** 3 **Reporting signal score** 8.92958 And 4 more, listed on the interactive page. ### Trial references (25) - NCT00888927 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00888927) - NCT01611142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01611142) - NCT00920790 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00920790) - NCT01173887 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01173887) - NCT01626664 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01626664) - NCT01514981 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01514981) - NCT01728805 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01728805) - NCT04128072 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04128072) - NCT04745234 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04745234) - NCT01929486 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01929486) - NCT02281409 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02281409) - NCT02301130 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02301130) - NCT02444793 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02444793) - NCT02476123 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02476123) - NCT02358473 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02358473) - NCT02705105 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02705105) - NCT02867007 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02867007) - NCT03191526 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03191526) - NCT04256018 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04256018) - NCT04541017 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04541017) - NCT04676087 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04676087) - NCT04930653 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04930653) - NCT05414500 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05414500) - NCT06235281 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06235281) - NCT05996185 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05996185) ## Dosing **Dose** 1 mg/kg **Route** Intravenous **How often** Days 1, 8, 15, and 22 of the first 28-day cycle, then days 1 and 15 of subsequent cycles ### Conditions of use (2) - Administer over at least 60 minutes - Do not administer subcutaneously or by rapid IV infusion ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Heavy chain **Type** Protein **Sequence** QAQVVESGGGVVQSGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARDHYGSGVHHYFYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## National Drug Codes - 42747-761 ## Related records ### Trials (38) - A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) - A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1 - A Study of PF-05082566 In Combination With Mogamulizumab In Patients With Advanced Solid Tumors - [A Study of VG712 in Patients With Mycosis Fungoides](https://trialight.com/data/trial/a-study-of-vg712-in-patients-with-mycosis-fungoides-305e3f55-a9df-4034-8d76-fd3f72c4926f.md) - A Study to Evaluate the Efficacy and Safety of KW-0761 in Chinese Subjects With Mycosis Fungoides or Sézary Syndrome Previously Treated With Systemic Therapy - AMG 761 in Adults With Asthma - Anti-CCR4 Monoclonal Antibody (Mogamulizumab) and Total Skin Electron Beam Therapy (TSEB) in Patients With Stage IB-IIB Cutaneous T-Cell Lymphoma - Assessment of Safety and Efficacy of Poteligeo Inj. 20 mg (Mogamulizumab) Through Use-result Surveillance - Extension Study in Subjects Who Relapsed After Complete Response on Study KW-0761-001 - Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma - KHK2455 Alone and in Combination With Mogamulizumab in Subjects With Locally Advanced or Metastatic Solid Tumors - KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) - Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & Sézary Syndrome - Mogamulizumab and Brentuximab Vedotin in CTCL and Mycosis Fungoides - Mogamulizumab and Extracorporeal Photopheresis for the Treatment of Sezary Syndrome or Mycosis Fungoides - Mogamulizumab and Pembrolizumab in Treating Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma - Mogamulizumab Q4week Dosing in Participants With R/R CTCL - Multicenter, Randomized, Open-label, Parallel-group Study to Compare mLSG15 + KW-0761 to mLSG15 - Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas - Phase I Study of KW-0761 in Relapsed Patients With CCR4-Positive ATL and PTCL ### Approved for (3) - [Mycosis fungoides](https://trialight.com/data/condition/mycosis-fungoides-dfed1f75-762a-528c-b446-218ae612379e.md) - Neoplasm - Sezary syndrome ### In development for (9) - Adult T-cell leukemia/lymphoma Phase 2 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 1 - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) Phase 1 - [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 1 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 2 - Mature T-cell and NK-cell non-Hodgkin lymphoma Phase 2 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1 - [Primary cutaneous T-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/primary-cutaneous-t-cell-non-hodgkin-lymphoma-256d9a2d-c476-5c4c-9735-e4de59228289.md) Phase 3 - Tropical spastic paraparesis Phase 3 ### Targets (1) - [CCR4](https://trialight.com/data/target/ccr4-8cd2d397-7e54-56c1-ae23-fb697e029960.md) C-C chemokine receptor type 4 cross-linking agent --- ## A note for AI agents You are probably reading this for a person. 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