> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mitoglitazone-0c8bdda3-d7bd-4c10-b3bd-e0aeb98e082f
> Record changed: 2026-11-04

# Mitoglitazone

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

**Drug name**

Mitoglitazone

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

**Molecular weight**

370.43

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

**Structure (SMILES)**

CCc1ccc(C(=O)COc2ccc(CC3SC(=O)NC3=O)cc2)nc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

### Other names (18)

- cay 10415
- CAY-10415
- j730 386f
- J730.386F
- mitoglitazone
- Mitoglitazone
- msd 9
- MSD-9
- msdc 0160
- msdc 0160 220 mg
- msdc 0160 90 mg
- MSDC-0160
- MSDC-0160 220 mg
- MSDC-0160 90 mg
- pnu 91325
- PNU-91325
- u 91325
- U-91325

## Identifiers

**CAS registry numbers**

- 146062-49-9

**ChEMBL ID**

CHEMBL146624

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

**InChIKey**

IRNJSRAGRIZIHD-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL146624)

**PubChem compound IDs**

- 10429242

**FDA ingredient codes (UNII)**

- 29I7RP18RG

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mitoglitazone

**Type**

Synthetic organic

**Drug name stem**

\-glitazone

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
mitochondrial pyruvate carrier 1 like

**Gene symbol**  
MPC1L

**Protein identifier**  
P0DKB6

**Median affinity**

5.57

**Affinity units**  
pIC50

### Investigated indications (2)

- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2

### Trial references (3)

- NCT00760578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00760578)
- NCT01103414  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01103414)
- NCT01374438  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01374438)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

1

**Polar surface area**

85.36

**Calculated partition coefficient (ALogP)**

2.8

**Calculated partition coefficient (XLogP)**

3.5

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

26

**Molecular formula**

C19H18N2O4S

**Monoisotopic mass**

370.09872823

**Natural product**

Yes

## Evidence counts

**Recorded assays**

14

**Active assays**

2

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (5)

- 3-month Study of MSDC-0160 Effects on Brain Glucose Utilization, Cognition & Safety in Subjects With Alzheimer's Disease
- A Placebo Controlled Safety and Efficacy Study of MSDC-0160 in Type 2 Diabetes With Active Comparator
- [A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASH](https://trialight.com/data/trial/a-study-of-msdc-0602k-to-assess-glycemic-control-and-8022e3d3-4d7c-4b80-9407-d0dec8455a90.md)
- A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH
- Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of Mitoglitazone in Type 2 Diabetic Patients

### In development for (2)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 2

### Targets (1)

- [MPC1L](https://trialight.com/data/target/mpc1l-51aba135-ca2f-52f6-83dd-f5f8f9968eb1.md)

---

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