> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mitiperstat-bdc25dd1-b024-4111-8018-788c44a6e9e7
> Record changed: 2026-10-13

# Mitiperstat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

**Drug name**

Mitiperstat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

**Molecular weight**

334.83

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

**Structure (SMILES)**

C\[C@@H\](N)c1cc(Cl)ccc1Cn1c(=S)\[nH\]c(=O)c2\[nH\]ccc21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

### Other names (14)

- azd 4831
- Azd 4831
- AZD 4831 \[WHO-DD\]
- azd 4831 who dd
- AZD-4831
- azd4831
- AZD4831
- mitiperstat
- Mitiperstat
- Mitiperstat (AZD4831)
- mitiperstat \[INN\]
- MITIPERSTAT \[USAN\]
- mitiperstat inn
- mitiperstat usan

## Identifiers

**CAS registry numbers**

- 1933460-19-5

**ChEMBL ID**

CHEMBL5095218

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

**InChIKey**

BHKKSKOHRFHHIN-MRVPVSSYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095218)

**PubChem compound IDs**

- 121362450

**FDA ingredient codes (UNII)**

- S6GYK3X4QQ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mitiperstat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
myeloperoxidase

**Gene symbol**  
MPO

**Protein identifier**  
P05164

**Median affinity**

9.15

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
thyroid peroxidase

**Gene symbol**  
TPO

**Protein identifier**  
P07202

**Median affinity**

6.16

**Affinity units**  
pIC50
- **Action**  
Irreversible inhibition

**Action type**  
IRREVERSIBLE\_INHIBITION

**Target**  
myeloperoxidase

**Gene symbol**  
MPO

**Protein identifier**  
P05164

**Median affinity**

8.82

**Affinity units**  
pIC50

### Investigated indications (5)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Heart Failure

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003144
- **Condition identifier**  
EFO\_0006890

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005252

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007027

**Highest recorded phase**  
2

### Trial references (10)

- NCT02712372  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02712372)
- NCT03136991  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03136991)
- NCT04407091  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04407091)
- NCT03611153  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03611153)
- NCT03756285  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03756285)
- NCT04232345  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04232345)
- NCT04986202  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04986202)
- NCT04949438  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04949438)
- NCT05492877  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05492877)
- NCT05751759  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05751759)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

3

**Polar surface area**

79.6

**Calculated partition coefficient (ALogP)**

3.11

**Calculated partition coefficient (XLogP)**

1.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

22

**Molecular formula**

C15H15ClN4OS

**Monoisotopic mass**

334.0655100

**Natural product**

No

## Evidence counts

**Recorded assays**

46

**Active assays**

13

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (14)

- A Phase I, Safety Tolerability and Pharmacokinetics of AZD4831 to Treat Cardiovascular Disease
- A Study in Participants With Non-cirrhotic NASH With Fibrosis
- A Study to Assess the Effect AZD4831 in Japanese and Chinese Healthy Volunteers
- A Study to Assess the Mass Balance Recovery, Pharmacokinetics, Metabolite Profile and Metabolite Identification of \[14C\]AZD4831
- A Study to Assess the Pharmacokinetics (Uptake of Drugs by the Body), Safety and Tolerability of AZD4831 in Participants With Severe Renal Impairment and Healthy Volunteers
- A Study to Assess the Pharmacokinetics of AZD4831 When Administered Alone and in Combination With Itraconazole
- A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers.
- A Study to Assess the Safety and Tolerability of Single and Multiple Doses of AZD4831 in Healthy Male Subjects
- [An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.](https://trialight.com/data/trial/an-efficacy-and-safety-study-of-mitiperstat-azd4831-mpo-5ee89c73-90a3-4a43-8d96-033bec5155d4.md)
- Myeloperoxidase (MPO) Inhibitor A\_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF)
- Pharmacokinetics of Mitiperstat in Participants With Hepatic Impairment
- Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
- Study to Assess the Effect of AZD4831 on the Pharmacokinetics (Drug Behavior in the Body) of Midazolam
- Study to Evaluate the Efficacy and Safety of AZD4831 in Participants With Heart Failure With Left Ventricular Ejection Fraction > 40%

### In development for (5)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1

---

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