> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/miricorilant-87cc7505-5b35-47de-8d53-a5f80ba45e80
> Record changed: 2026-10-13

# Miricorilant

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

**Drug name**

Miricorilant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

**Molecular weight**

428.45

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

**Structure (SMILES)**

O=c1\[nH\]c(=O)c(Cc2cccc(C(F)(F)F)c2)c(\[C@H\]2CC\[C@H\](c3ccccc3)CC2)\[nH\]1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

### Other names (20)

- cort 118335
- CORT-118335
- cort118335
- Cort118335
- CORT118335
- CORT118335 Oral
- miricorilant
- Miricorilant
- Miricorilant (Cohort A)
- Miricorilant (Cohort B)
- miricorilant \[INN\]
- MIRICORILANT \[USAN\]
- Miricorilant 10 mg
- Miricorilant 100 mg
- Miricorilant 150 mg
- Miricorilant 150 mg tablets
- Miricorilant 300 mg tablets
- Miricorilant 50 mg
- miricorilant inn
- miricorilant usan

## Identifiers

**CAS registry numbers**

- 1400902-13-7

**ChEMBL ID**

CHEMBL4297602

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

**InChIKey**

GVVUZBSCYAVFTI-IYARVYRRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297602)

**PubChem compound IDs**

- 66550324

**FDA ingredient codes (UNII)**

- 311Y5GV21M

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

miricorilant

**Type**

Synthetic organic

**Drug name stem**

\-corilant

### Mechanisms of action

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
Glucocorticoid receptor

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Median affinity**

8.1

**Affinity units**  
pKi

**Primary target**  
Yes

### Investigated indications (6)

- **Condition**  
Psychotic Disorders

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000677

**Subject identifier**  
D011618
- **Condition**  
Weight Gain

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004566

**Subject identifier**  
D015430
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001249

**Subject identifier**  
D065626
- **Condition**  
Weight Gain

**Highest recorded phase**  
2

**Condition identifier**  
HP:0004324

**Subject identifier**  
D015430
- **Condition**  
Alcoholism

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007079

**Subject identifier**  
D000437
- **Condition**  
Metabolic Diseases

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0019052

**Subject identifier**  
D008659

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000677
- **Condition identifier**  
EFO\_0004566

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001249

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0004324
- **Condition identifier**  
HP\_0004324

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004985

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005084
- **Condition identifier**  
MONDO\_0005090

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007027

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007079

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019052

### Trial references (4)

- NCT03818256  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03818256)
- NCT03823703  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03823703)
- NCT05117489  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05117489)
- NCT04466215  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04466215)

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

2

**Polar surface area**

65.72

**Calculated partition coefficient (ALogP)**

5.11

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

31

**Molecular formula**

C24H23F3N2O2

**Natural product**

No

## Evidence counts

**Recorded assays**

25

**Active assays**

2

### Active assay types

- Confirmatory

## Related records

### Trials (30)

- A Phase 1 Study of BRG01 in Subjects With Relapsed/Metastatic Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma
- A Phase 2b, Study Evaluating Miricorilant in Adult Patients With Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH)
- A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Patients With Presumed Nonalcoholic Steatohepatitis (NASH)
- [A Study of Ponsegromab in People With Heart Failure](https://trialight.com/data/trial/a-study-of-ponsegromab-in-people-with-heart-failure-c661dd5b-9ade-47ab-ab59-d6a6a4ada045.md)
- A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma
- A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adults With Schizophrenia or Bipolar Disorder Treated With Antipsychotic Medications
- A Study to Evaluate the Efficacy and Safety of ORMD-0801 (Oral Insulin) in Patients With Type 2 Diabetes Mellitus
- A Study to Investigate Efficacy and Safety of NSI-8226 in Healthy Participants
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibody (mAb) in Patients With IPF (SAD).
- Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants
- CPX-351 in Higher Risk Myelodysplastic Syndromes
- Dose Escalation Study to Evaluate the Safety and Immunogenicity of the Cholera Conjugate Vaccine in Healthy Adults
- Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
- Evaluating the Pharmacokinetics and Safety of Miricorilant
- Evaluation of Miricorilant on Liver Fat in Patients With MASLD
- First-in-human Study in Healthy Subjects
- [JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)](https://trialight.com/data/trial/just-breathe-breathing-life-into-innovative-therapies-for-b9153690-ceb2-4470-888a-92b70ddd73e7.md)
- JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
- Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
- Mutant KRAS -Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer

### In development for (4)

- [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 2
- Inborn errors of metabolism Phase 1
- [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) Phase 1
- [Metabolic dysfunction-associated steatohepatitis](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65.md) Phase 2

---

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