> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/minocycline-0789feeb-1396-4fb9-bfd9-d51fefbb5e59 > Record changed: 2026-10-13 # Minocycline Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) First approval year 1971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) ## Development status **First approval year** 1971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **Drug name** Minocycline Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **Molecular weight** 457.48 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **Structure (SMILES)** CN(C)c1ccc(O)c2c1C\[C@H\]1C\[C@H\]3\[C@H\](N(C)C)C(O)=C(C(N)=O)C(=O)\[C@@\]3(O)C(O)=C1C2=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) ### Other names (24) - 2 naphthacenecarboxamide 4 7 bis dimethylamino 1 4 4a 5 5a 6 11 12a octahydro 3 10 12 12a tetrahydroxy 1 11 dioxo 4s 4 alpha 4a alpha 5a alpha 12a alpha - 2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, (4S-(4.ALPHA.,4A.ALPHA.,5A.ALPHA.,12A.ALPHA.))- - 4 7 bis dimethylamino 1 4 4a 5 5a 6 11 12a octahydro 3 10 12 12a tetrahydroxy 1 11 dioxo 2 naphthacenecarboxamide - 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide - minociclina - Minociclina - minocycline - Minocycline - MINOCYCLINE \[HSDB\] - minocycline \[INN\] - MINOCYCLINE \[MART.\] - MINOCYCLINE \[MI\] - MINOCYCLINE \[USAN\] - MINOCYCLINE \[VANDF\] - Minocycline \[WHO-DD\] - minocycline hsdb - minocycline inn - minocycline mart - minocycline mi - minocycline usan - minocycline vandf - minocycline who dd - TIGECYCLINE IMPURITY C \[EP IMPURITY\] - tigecycline impurity c ep impurity ## Identifiers **CAS registry numbers** - 10118-90-8 **ChEMBL ID** CHEMBL1434 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **InChIKey** DYKFCLLONBREIL-KVUCHLLUSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) **FDA ingredient codes (UNII)** - FYY3R43WGO ### ATC classification codes (3) - A01AB23 - D10AF07 - J01AA08 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1434) ### RxNorm IDs (RxCUI) (2) - 6979 - 6980 ## Regulatory information ### United States **Applicant** TRIAX PHARMS **Approval date** 30 Jun 1971 **Application number** NDA050315 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** minocycline **Type** Synthetic organic **Drug name stem** \-cycline **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral - topical ### Open Targets mechanisms - **Mechanism** Bacterial 70S ribosome inhibitor **Action type** Inhibitor **Target** Bacterial 70S ribosome ### Investigated indications (73) - **Condition** Atrial Fibrillation **Highest recorded phase** 2 **Condition identifier** EFO:0000275 **Subject identifier** D001281 - **Condition** Glioblastoma **Highest recorded phase** 1 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Hypertension **Highest recorded phase** 3 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Periodontitis **Highest recorded phase** 3 **Condition identifier** EFO:0000649 **Subject identifier** D010518 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 3 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Skin Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** HIV Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Idiopathic Pulmonary Fibrosis **Highest recorded phase** 3 **Condition identifier** EFO:0000768 **Subject identifier** D054990 - **Condition** Bacterial Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000771 **Subject identifier** D001424 - **Condition** Memory Disorders **Highest recorded phase** 1 **Condition identifier** EFO:0001072 **Subject identifier** D008569 - **Condition** Macular Degeneration **Highest recorded phase** 2 **Condition identifier** EFO:0001365 **Subject identifier** D008268 - **Condition** Multiple Myeloma **Highest recorded phase** 2 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Carotid Stenosis **Highest recorded phase** 2 **Condition identifier** EFO:0002615 **Subject identifier** D016893 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 2 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Osteomyelitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0003102 **Subject identifier** D010019 - **Condition** Pneumonia **Highest recorded phase** 1 **Condition identifier** EFO:0003106 **Subject identifier** D011014 - **Condition** Child Development Disorders, Pervasive **Highest recorded phase** 1 **Condition identifier** EFO:0003756 **Subject identifier** D002659 - **Condition** Autistic Disorder **Highest recorded phase** 1 **Condition identifier** EFO:0003758 **Subject identifier** D001321 - **Condition** Depressive Disorder, Major **Highest recorded phase** 2 **Condition identifier** EFO:0003761 **Subject identifier** D003865 - **Condition** Inflammatory Bowel Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003767 **Subject identifier** D015212 - **Condition** Substance-Related Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0003890 **Subject identifier** D019966 - **Condition** Acne Vulgaris **Highest recorded phase** 4 **Condition identifier** EFO:0003894 **Subject identifier** D000152 And 48 more, listed on the interactive page. ### Open Targets indications (135) - **Condition identifier** EFO\_0000401 - **Condition identifier** EFO\_0000537 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000649 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000685 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000701 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000712 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000768 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000771 - **Condition identifier** EFO\_0001072 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001365 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002615 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003102 - **Condition identifier** EFO\_0003106 - **Condition identifier** EFO\_0003756 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003758 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003767 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003890 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003894 - **Condition identifier** EFO\_0003929 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004240 **Highest recorded phase** 3 And 110 more, listed on the interactive page. ### Reported adverse events (80) - **Event** abdominal distension **Reports** 43 **Reporting signal score** 31.8735 - **Event** acute febrile neutrophilic dermatosis **Reports** 15 **Reporting signal score** 38.0345 - **Event** anti-neutrophil cytoplasmic antibody positive vasculitis **Reports** 21 **Reporting signal score** 63.5055 - **Event** antineutrophil cytoplasmic antibody positive **Reports** 8 **Reporting signal score** 27.2678 - **Event** antinuclear antibody positive **Reports** 15 **Reporting signal score** 30.3393 - **Event** apparent death **Reports** 27 **Reporting signal score** 90.1804 - **Event** application site discolouration **Reports** 11 **Reporting signal score** 31.7842 - **Event** arteritis **Reports** 10 **Reporting signal score** 35.6599 - **Event** arthralgia **Reports** 123 **Reporting signal score** 49.0199 - **Event** arthritis **Reports** 82 **Reporting signal score** 120.965 - **Event** autoimmune hepatitis **Reports** 53 **Reporting signal score** 144.952 - **Event** benign intracranial hypertension **Reports** 11 **Reporting signal score** 28.7674 - **Event** bone erosion **Reports** 73 **Reporting signal score** 299.838 - **Event** bone hyperpigmentation **Reports** 46 **Reporting signal score** 298.115 - **Event** c-reactive protein abnormal **Reports** 27 **Reporting signal score** 67.7579 - **Event** c-reactive protein increased **Reports** 46 **Reporting signal score** 53.4105 - **Event** chronic hepatitis **Reports** 11 **Reporting signal score** 34.6812 - **Event** conjunctival pigmentation **Reports** 12 **Reporting signal score** 73.594 - **Event** diverticulitis **Reports** 28 **Reporting signal score** 31.1786 - **Event** drug hypersensitivity **Reports** 134 **Reporting signal score** 77.5986 - **Event** drug intolerance **Reports** 187 **Reporting signal score** 302.929 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 139 **Reporting signal score** 320.768 - **Event** drug-induced liver injury **Reports** 95 **Reporting signal score** 190.648 - **Event** dyspepsia **Reports** 44 **Reporting signal score** 36.8739 - **Event** eosinophilia **Reports** 28 **Reporting signal score** 33.7785 And 55 more, listed on the interactive page. ### Trial references (117) - NCT00029874 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00029874) - NCT00277355 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00277355) - NCT00047723 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00047723) - NCT00355576 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00355576) - NCT00063193 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00063193) - NCT00145106 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00145106) - NCT00240513 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00240513) - NCT00392223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00392223) - NCT00988026 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00988026) - NCT01206348 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01206348) - NCT01362010 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01362010) - NCT02250859 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02250859) - NCT02695446 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02695446) - NCT02815267 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02815267) - NCT02815280 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02815280) - NCT02815332 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02815332) - NCT02946788 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02946788) - NCT00154895 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00154895) - NCT00203112 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00203112) - NCT00666887 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00666887) - NCT04291456 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04291456) - NCT00203697 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00203697) - NCT00361257 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00361257) - NCT00371332 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00371332) - NCT00662532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00662532) And 92 more, listed on the interactive page. ## Dosing **Dose** Approx. 1 mg/kg **Route** Oral **How often** Once daily ### Conditions of use (2) - Food may reduce esophageal irritation - May be taken with or without food ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 5 **Polar surface area** 164.63 **Calculated partition coefficient (ALogP)** 0.19 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 33 **Molecular formula** C23H27N3O7 **Natural product** Yes ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 98.75 **Mean** 98.75 **Minimum** 97.5 **Maximum** 100 **Unit** % **Assays** 2 **Standard deviation** 1.76777 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (197) - A Comparative Bioavailability Study of DFD-29 Capsules 40 mg Versus SOLODYN® Tablets 105 mg, Under Fasting & Fed Conditions in Healthy Adult Human Subjects - A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa - A Pharmacokinetic Study of Minocycline in Male and Female Volunteers - A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer - A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema - A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression - A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients - A Pilot Study of the Effect of Minocycline on Cerebrospinal Fluid HIV-1 Infection - A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma - A Proof-of-Concept Study of Minocycline in Autism - A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World Setting - A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea - A Study (Study 2) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea - A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil - A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy - A Study to Compare FCD105 Foam to Minocycline 3% Foam, Adapalene 0.3% Foam and Vehicle Foam. - A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne - A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne - A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males. - A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54175446 in Healthy Male Participants ### Approved for (2) - [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) ### In development for (63) - [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 2 - [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 1 - [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 3 - Angelman syndrome Phase 2 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 2 - Autism Phase 1 - Autism spectrum disorder Phase 1 - Autoimmune encephalitis Phase 2 - Bipolar disorder Phase 3 - Brain injury Phase 1 - Cerebral amyloid angiopathy Phase 1 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2 - [Cystic fibrosis](https://trialight.com/data/condition/cystic-fibrosis-6f9870eb-6ebc-5bec-a50b-34b0b323a7c3.md) Phase 2 - Cystoid macular edema Phase 1 - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 3 - Drug dependence Phase 3 - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 2 - Exocrine pancreatic carcinoma Phase 2 - Fibromyalgia Phase 1 ### Other linked conditions (3) - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) - [Diabetic macular edema](https://trialight.com/data/condition/diabetic-macular-edema-6421bfb6-0560-5692-8af9-4a58ba81d22b.md) - [Gram-negative bacterial infections](https://trialight.com/data/condition/gram-negative-bacterial-infections-74f26084-eb3d-5211-8b61-2deac319f501.md) --- ## A note for AI agents You are probably reading this for a person. 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