> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/milvexian-339c16a0-10d4-46bb-9570-47b9050a80b1
> Record changed: 2026-10-13

# Milvexian

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

**Drug name**

Milvexian

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

**Molecular weight**

626.46

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

**Structure (SMILES)**

C\[C@@H\]1CCC\[C@H\](n2cnc(-c3cc(Cl)ccc3-n3cc(Cl)nn3)cc2=O)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

### Other names (21)

- bms 986177
- BMS 986177
- Bms-986177
- BMS-986177
- BMS-986177 Oral Solution
- jnj 70033093
- Jnj-70033093
- JNJ-70033093
- JNJ-70033093 100 mg
- JNJ-70033093 200 mg
- JNJ-70033093 25 mg
- JNJ-70033093 50 mg
- milvexian
- Milvexian
- MILVEXIAN
- milvexian \[INN\]
- MILVEXIAN \[USAN\]
- Milvexian \[WHO-DD\]
- milvexian inn
- milvexian usan
- milvexian who dd

## Identifiers

**CAS registry numbers**

- 1802425-99-5

**ChEMBL ID**

CHEMBL4112929

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

**InChIKey**

FSWFYCYPTDLKON-CMJOXMDJSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4112929)

**PubChem compound IDs**

- 118277544

**FDA ingredient codes (UNII)**

- 0W79NDQ608

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

milvexian

**Type**

Synthetic organic

**Drug name stem**

\-xian

### Mechanisms of action (4)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
coagulation factor XI

**Gene symbol**  
F11

**Protein identifier**  
P03951

**Median affinity**

9.96

**Affinity units**  
pKi
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
kallikrein B1

**Gene symbol**  
KLKB1

**Protein identifier**  
P03952

**Median affinity**

7.36

**Affinity units**  
pKi
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
chymotrypsin C

**Gene symbol**  
CTRC

**Protein identifier**  
Q99895

**Median affinity**

7.46

**Affinity units**  
pKi
- **Mechanism**  
Coagulation factor XI inhibitor

**Action type**  
Inhibitor

**Target**  
Coagulation factor XI

**Protein identifier**  
P03951

### Open Targets mechanisms

- **Mechanism**  
Coagulation factor XI inhibitor

**Action type**  
Inhibitor

**Target**  
Coagulation factor XI

### Investigated indications (3)

- **Condition**  
Atrial Fibrillation

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Acute Coronary Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005672

**Subject identifier**  
D054058
- **Condition**  
Thrombosis

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0000831

**Subject identifier**  
D013927

### Open Targets indications (7)

- **Condition identifier**  
EFO\_0000275

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005672

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009909

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0002140

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0002637

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000831

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_1060198

**Highest recorded phase**  
2

### Trial references (10)

- NCT02608970  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02608970)
- NCT02807909  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02807909)
- NCT02959060  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02959060)
- NCT02982707  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02982707)
- NCT03196206  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03196206)
- NCT03224260  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03224260)
- NCT03362437  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03362437)
- NCT03939702  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03939702)
- NCT05754957  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05754957)
- NCT05757869  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05757869)

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

1

**Polar surface area**

125.41

**Calculated partition coefficient (ALogP)**

5.8

**Calculated partition coefficient (XLogP)**

4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

4

**Heavy atoms**

43

**Molecular formula**

C28H23Cl2F2N9O2

**Monoisotopic mass**

625.1319827

**Natural product**

No

## Evidence counts

**Recorded assays**

57

**Active assays**

21

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Solubility

**Median**

7

**Mean**

7

**Minimum**

6

**Maximum**

8

**Unit**

ug/mL

**Assays**

2

**Standard deviation**

1.41421

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

25

**Mean**

25

**Minimum**

18

**Maximum**

32

**Unit**

%

**Assays**

4

**Standard deviation**

8.0829

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (26)

- A Study Evaluating Drug Drug Interaction Between Milvexian and Atorvastatin in Healthy Participants
- A Study of JNJ-70033093 (BMS-986177) in Healthy Adult Participants
- A Study of JNJ-70033093 (BMS-986177) in Healthy Chinese Adult Participants
- A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery
- A Study of JNJ-70033093 (Milvexian) in Healthy Adult Participants
- A Study of JNJ-70033093 and Digoxin in Healthy Participants
- A Study of JNJ-70033093 in Healthy Participants
- A Study of Milvexian in Healthy Adult Females
- [A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome](https://trialight.com/data/trial/a-study-of-milvexian-in-participants-after-a-recent-acute-0b485d43-2b27-4d92-b8a0-1716a132b945.md)
- [A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE](https://trialight.com/data/trial/a-study-of-milvexian-in-participants-after-an-acute-ischemic-ef73fb8c-7882-4291-a1aa-bb4cc7f9d2a3.md)
- A Study of Milvexian Using an IV Microtracer With Additional Formulation and Food Effect Comparison in Healthy Participants
- [A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation](https://trialight.com/data/trial/a-study-of-milvexian-versus-apixaban-in-participants-with-e26ab0d2-647d-49a6-bf8b-cc799e52b193.md)
- A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel
- A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects
- A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants
- A Study to Evaluate Safety of Single Doses of BMS-986177 in Patients With End Stage Renal Disease (ESRD) Treated With Hemodialysis
- A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Pharmacokinetics of BMS-986177 in Healthy Subjects
- A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics of BMS-986177 in Healthy Subjects
- A Study to Evaluate the Safety and Pharmacokinetics of BMS-986177 in Participants With End-stage Renal Dysfunction on Chronic Stable Hemodialysis Treatment
- An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants

### In development for (3)

- [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 3
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3
- [Thrombotic disease](https://trialight.com/data/condition/thrombotic-disease-3f54ef10-d2ed-524f-a020-8ecb2eb62a52.md) Phase 1

### Targets (1)

- [F11](https://trialight.com/data/target/f11-ee6a0377-9fea-5dd3-a409-ae140fbedce5.md) Coagulation factor XI inhibitor

---

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