> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/midazolam-1bd7ce5f-a598-4c40-a36b-e990c47207ef > Record changed: 2026-10-13 # Midazolam Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) First approval year 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) ## Development status **First approval year** 1985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **Drug name** Midazolam Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **Molecular weight** 325.77 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **Structure (SMILES)** Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) ### Brand names (6) - midazolam in 0 8 sodium chloride - midazolam in 0 9 sodium chloride - Midazolam in 0.8% sodium chloride - Midazolam in 0.9% sodium chloride - nayzilam - Nayzilam ### Other names (32) - 4h imidazo 1 5 a 1 4 benzodiazepine 8 chloro 6 2 fluorophenyl 1 methyl - 4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE, 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL - dormicum - DORMICUM - midazolam - Midazolam - MIDAZOLAM \[EP MONOGRAPH\] - midazolam \[INN\] - MIDAZOLAM \[JAN\] - MIDAZOLAM \[MART.\] - MIDAZOLAM \[MI\] - MIDAZOLAM \[ORANGE BOOK\] - MIDAZOLAM \[USP MONOGRAPH\] - MIDAZOLAM \[VANDF\] - Midazolam \[WHO-DD\] - midazolam civ - Midazolam civ - MIDAZOLAM CIV \[USP-RS\] - midazolam civ usp rs - midazolam ep monograph - midazolam inn - midazolam jan - midazolam mart - midazolam mi - midazolam orange book And 7 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N05CD08 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **CAS registry numbers** - 59467-70-8 **ChEMBL ID** CHEMBL655 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **InChIKey** DDLIGBOFAVUZHB-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL655) **PubChem compound IDs** - 4192 **FDA ingredient codes (UNII)** - R60L0SM5BC ### RxNorm IDs (RxCUI) (2) - 6960 - 142441 ## Regulatory information ### United States **Applicant** UCB INC **Approval date** 17 May 2019 **Application number** NDA211321 ### European Union **Status** Authorised **Status date** 4 Sept 2011 **Authorisation date** 4 Sept 2011 **Approved indications** Treatment of prolonged, acute, convulsive seizures in infants from 3 months to adults.BUCCOLAM must only be used by parents/carers where the patient has been diagnosed to have epilepsy.For infants between 3-6 months of age treatment should be in a hospital setting where monitoring is possible and resuscitation equipment is available. See section 4.2. **Product number** EMEA/H/C/002267 **Authorisation holder** Neuraxpharm Pharmaceuticals S.L. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Epilepsy European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/buccolam) ### Other regulatory facts **Patents** 5 **Designations** 1 **Earliest recorded loss of exclusivity** 20 Jun 2038 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** midazolam **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral - topical ### Mechanisms of action (16) - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O00591 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O14764 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P14867 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18505 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18507 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P28472 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P31644 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P34903 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47869 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47870 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P48169 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P78334 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q16445 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q8N1C3 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q99928 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q9UN88 ### Open Targets mechanisms - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE ALLOSTERIC MODULATOR **Target** GABA-A receptor; anion channel ### DrugCentral mechanisms (8) - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRG2|GABRB2 **Protein identifier** P14867|P18507|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRB2|GABRG3 **Protein identifier** P14867|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRB3|GABRA5 **Protein identifier** P18507|P28472|P31644 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRA5|GABRB2 **Protein identifier** P18507|P31644|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRA3|GABRB2 **Protein identifier** P18507|P34903|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRB3|GABRA5|GABRG3 **Protein identifier** P28472|P31644|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA5|GABRB2|GABRG3 **Protein identifier** P31644|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA3|GABRB2|GABRG3 **Protein identifier** P34903|P47870|Q99928 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (115) - **Condition** Trypanosomiasis **Highest recorded phase** 1 **Condition identifier** DOID:10113 **Subject identifier** D014352 - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Dermatitis, Atopic **Highest recorded phase** 1 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Cardiovascular Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 1 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Crohn Disease **Highest recorded phase** 1 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Epilepsy **Highest recorded phase** 4 **Condition identifier** EFO:0000474 **Subject identifier** D004827 - **Condition** Hypertension **Highest recorded phase** 3 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Infertility **Highest recorded phase** 3 **Condition identifier** EFO:0000545 **Subject identifier** D007246 - **Condition** Wounds and Injuries **Highest recorded phase** 3 **Condition identifier** EFO:0000546 **Subject identifier** D014947 - **Condition** Mesothelioma **Highest recorded phase** 1 **Condition identifier** EFO:0000588 **Subject identifier** D008654 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Prostatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000673 **Subject identifier** D011471 - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 1 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Skin Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000701 **Subject identifier** D012871 - **Condition** Subarachnoid Hemorrhage **Highest recorded phase** 2 **Condition identifier** EFO:0000713 **Subject identifier** D013345 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Melanoma **Highest recorded phase** 1 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Endometriosis **Highest recorded phase** 1 **Condition identifier** EFO:0001065 **Subject identifier** D004715 - **Condition** Malaria **Highest recorded phase** 1 **Condition identifier** EFO:0001068 **Subject identifier** D008288 - **Condition** Obesity **Highest recorded phase** 1 **Condition identifier** EFO:0001073 **Subject identifier** D009765 And 90 more, listed on the interactive page. ### Open Targets indications (150) - **Condition identifier** DOID\_10113 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000095 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000222 - **Condition identifier** EFO\_0000341 - **Condition identifier** EFO\_0000474 - **Condition identifier** EFO\_0000537 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000545 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000546 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000673 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000756 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000764 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001065 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001073 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001358 - **Condition identifier** EFO\_0001422 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001645 - **Condition identifier** EFO\_0003015 - **Condition identifier** EFO\_0003015 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003103 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003768 And 125 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning ### Open Targets warnings (3) - **Warning** Black Box Warning **Country** United States - **Warning** Black Box Warning **Effect** misuse **Country** United States - **Warning** Black Box Warning **Effect** respiratory toxicity **Country** United States ### Reported adverse events (57) - **Event** acidosis hyperchloraemic **Reports** 19 **Reporting signal score** 68.1958 - **Event** agitation **Reports** 135 **Reporting signal score** 134.276 - **Event** anaesthetic complication neurological **Reports** 29 **Reporting signal score** 119.144 - **Event** anaphylactic reaction **Reports** 179 **Reporting signal score** 232.407 - **Event** anaphylactic shock **Reports** 92 **Reporting signal score** 138.832 - **Event** anorectal ulcer **Reports** 10 **Reporting signal score** 53.9605 - **Event** apnoea **Reports** 52 **Reporting signal score** 104.801 - **Event** bradycardia **Reports** 124 **Reporting signal score** 103.023 - **Event** cardiac arrest **Reports** 104 **Reporting signal score** 146.888 - **Event** circulatory collapse **Reports** 47 **Reporting signal score** 64.8312 - **Event** cognitive disorder **Reports** 71 **Reporting signal score** 70.1201 - **Event** coma **Reports** 101 **Reporting signal score** 112.428 - **Event** congenital visual acuity reduced **Reports** 11 **Reporting signal score** 55.7619 - **Event** delayed recovery from anaesthesia **Reports** 26 **Reporting signal score** 85.5134 - **Event** delirium **Reports** 145 **Reporting signal score** 226.052 - **Event** depressed level of consciousness **Reports** 78 **Reporting signal score** 70.3447 - **Event** diabetes insipidus **Reports** 30 **Reporting signal score** 76.7161 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 120 **Reporting signal score** 179.308 - **Event** drug resistance **Reports** 59 **Reporting signal score** 60.8368 - **Event** drug withdrawal syndrome neonatal **Reports** 33 **Reporting signal score** 52.2404 - **Event** encephalopathy **Reports** 55 **Reporting signal score** 52.9665 - **Event** fatigue **Reports** 31 **Reporting signal score** 85.1241 - **Event** female genital tract fistula **Reports** 21 **Reporting signal score** 58.6956 - **Event** generalised tonic-clonic seizure **Reports** 74 **Reporting signal score** 122.967 - **Event** haemodynamic instability **Reports** 33 **Reporting signal score** 59.5209 And 32 more, listed on the interactive page. ### Trial references (239) - NCT00030004 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00030004) - NCT00176670 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00176670) - NCT00290082 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290082) - NCT00942539 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00942539) - NCT02096900 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02096900) - NCT02374567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02374567) - NCT03069677 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03069677) - NCT03165500 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03165500) - NCT04586504 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04586504) - NCT05610969 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05610969) - NCT00221520 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00221520) - NCT00248729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00248729) - NCT00258050 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00258050) - NCT00326612 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00326612) - NCT00534378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00534378) - NCT06271096 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06271096) - NCT00336882 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00336882) - NCT05340803 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05340803) - NCT00416039 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00416039) - NCT00443170 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00443170) - NCT00467779 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00467779) - NCT01287598 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01287598) - NCT01517399 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01517399) - NCT01585623 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01585623) - NCT01596647 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01596647) And 214 more, listed on the interactive page. ## Dosing **Dose** Up to 2.5mg **Route** Intravenous ### Conditions of use (3) - Administer slowly over at least 2 minutes - Total dose usually not exceeding 5mg - Wait 2 minutes between doses ## Chemical properties **Hydrogen bond acceptors** 3 **Hydrogen bond donors** 0 **Polar surface area** 30.18 **Calculated partition coefficient (ALogP)** 4.32 **Calculated partition coefficient (XLogP)** 2.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 23 **Molecular formula** C18H13ClFN3 **Monoisotopic mass** 325.0782033 **Natural product** No ## National Drug Codes - 0264-8002 - 0264-8005 - 44567-610 - 44567-611 - 50474-500 - 71053-595 ## Evidence counts **Recorded assays** 638 **Active assays** 83 ### Active assay types (2) - Confirmatory - Other ## Pharmacologic actions - Adjuvants, Anesthesia Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000759.html) - Hypnotics and Sedatives Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D006993.html) - Anti-Anxiety Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014151.html) - Anesthetics, Intravenous Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018686.html) - GABA Modulators Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018757.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (1,034) - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296) - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Study to Evaluate the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Healthy Volunteers and Renal Impairment Patients - A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam - A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007) - A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury - A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects - A Comparision of Midazolam-dexmedetomidine With Dexmedetomidine Alone for Hemodynamic Stability and Quality of Sedation in Elderly Patients Under Spinal Anesthesia - A Comparison Between Propofol-Remifentanil and Midazolam-Remifentanil Sedation in the Intensive Care Unit - A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation - A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department - A Comparison of Midazolam and Zolpidem as Oral Premedication in Children - A Comparison of Sedative Drugs for Conscious Sedation During Ultrasound Guided Transbronchial Needle Aspiration - A Comparison of the Sedation During Endoscopy in Children - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose Escalation Study of ASP8273 in Subjects With Non-Small-Cell Lung Cancer (NSCLC) Who Have Epidermal Growth Factor Receptor (EGFR) Mutations - A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure ### Approved for (1) - Epilepsy ### In development for (92) - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 1 - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1 - [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 1 - Anemia Phase 1 - Anti-neutrophil antibody associated vasculitis Phase 1 - Anxiety Phase 3 - Aspergillosis Phase 1 - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 1 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 1 - [Autosomal dominant polycystic kidney disease](https://trialight.com/data/condition/autosomal-dominant-polycystic-kidney-disease-4beb5bfd-d32f-5dcd-bf5a-99032974b831.md) Phase 1 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 1 - Bipolar disorder Phase 2 - Bone fracture Phase 3 - Borderline personality disorder Phase 2 - Brain injury Phase 3 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 2 - Burn Phase 1 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1 - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1 ### Other linked conditions (5) - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) - Female breast carcinoma - [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) - [Insomnia](https://trialight.com/data/condition/insomnia-57f6af86-fd71-567b-813f-5867cfd4790c.md) - Vesicoureteral reflux ### Targets (16) - [GABRA1](https://trialight.com/data/target/gabra1-4391585d-ccfe-5231-89a4-e911338239fd.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA2](https://trialight.com/data/target/gabra2-8ad0509c-0869-5fa3-9f64-f2f16bbd75f7.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA3](https://trialight.com/data/target/gabra3-8295df29-4a16-5015-8651-ab3340e0de12.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA4](https://trialight.com/data/target/gabra4-8db035f5-598b-561c-bccf-339883590a0d.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA5](https://trialight.com/data/target/gabra5-b7313ea4-035e-5ccf-8477-4e09fa235563.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA6](https://trialight.com/data/target/gabra6-217bacdc-dfe0-5560-a2f5-7921b78e7abf.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB1](https://trialight.com/data/target/gabrb1-0f970126-9041-5d32-87ac-02bd10cef557.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB2](https://trialight.com/data/target/gabrb2-1a519e10-d490-5760-9751-7cc901cac6eb.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB3](https://trialight.com/data/target/gabrb3-d3c48a04-fd9e-59c1-9c06-5a36bbd7ce2a.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRD](https://trialight.com/data/target/gabrd-9320aad1-3e84-5d9b-9702-43d3de2273dc.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRE](https://trialight.com/data/target/gabre-38203809-e856-5ed9-b0df-ad994e506211.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG1](https://trialight.com/data/target/gabrg1-9fce5825-56bf-57ff-b57f-213bcd9cc866.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG2](https://trialight.com/data/target/gabrg2-36dc590b-0fa0-5d0f-bbb6-e831ae83d791.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG3](https://trialight.com/data/target/gabrg3-e56da4b8-b4dd-5273-ac25-9cb3b1e98de6.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRP](https://trialight.com/data/target/gabrp-1815637f-6695-5cdf-917f-29b7c1596d44.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRQ](https://trialight.com/data/target/gabrq-441cdc7f-1c46-5673-9300-cc381ae42f30.md) GABA-A receptor; anion channel positive allosteric modulator --- ## A note for AI agents You are probably reading this for a person. 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