> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mibavademab-2c530b5c-9ec4-4d42-aff7-3454ecd7d355
> Record changed: 2026-10-13

# Mibavademab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

**Drug name**

Mibavademab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

### Other names (11)

- IMMUNOGLOBULIN G4 (227-PROLINE), ANTI-(HUMAN LEPTIN RECEPTOR) (HUMAN MONOCLONAL REGN4461 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL REGN4461 .KAPPA.-CHAIN, DIMER
- immunoglobulin g4 227 proline anti human leptin receptor human monoclonal regn4461 gamma 4 chain disulfide with human monoclonal regn4461 kappa chain dimer
- mibavademab
- Mibavademab
- mibavademab \[INN\]
- mibavademab inn
- regn 4461
- REGN-4461
- regn4461
- Regn4461
- REGN4461

## Identifiers

**CAS registry numbers**

- 2305770-44-7

**ChEMBL ID**

CHEMBL4650509

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650509)

**FDA ingredient codes (UNII)**

- PHL2UDY3AB

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
Leptin receptor agonist

**Action type**  
Agonist

**Target**  
Leptin receptor

**Protein identifier**  
P48357

### Open Targets mechanisms

- **Mechanism**  
Leptin receptor agonist

**Action type**  
Agonist

**Target**  
Leptin receptor

### Investigated indications

- **Condition**  
Lipodystrophy, Congenital Generalized

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0027766

**Subject identifier**  
D052497

### Open Targets indications (8)

- **Condition identifier**  
EFO\_1000727
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0003074

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005347

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019182

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0020088

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0027766

**Highest recorded phase**  
3

### Trial references

- NCT04159415  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04159415)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (8)

- A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults
- A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
- [A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity](https://trialight.com/data/trial/a-study-of-tirzepatide-ly3298176-plus-mibavademab-compared-c3557fe0-b823-4551-acf4-9132fd6d2ef2.md)
- A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
- A Study to Examine the Safety, Tolerability and Biological Effects of REGN4461 in Healthy Volunteers
- A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
- Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy
- Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin Signaling

### In development for (2)

- Generalized lipodystrophy Phase 2
- Inherited obesity Phase 3

### Other linked conditions (1)

- Lipodystrophy

### Targets (1)

- [LEPR](https://trialight.com/data/target/lepr-e64d0b1f-f2f9-59a4-9ae4-f6871c5f5e34.md) Leptin receptor agonist

---

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