> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mezigdomide-a5f4e0d3-235e-444c-aca1-0c8eecbc5992
> Record changed: 2026-10-13

# Mezigdomide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

**Drug name**

Mezigdomide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

**Molecular weight**

567.62

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

**Structure (SMILES)**

N#Cc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN(\[C@H\]4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

### Other names (18)

- cc 92480
- Cc-92480
- CC-92480
- cc92480
- CC92480
- cpd 3 cc 92480
- CPD. 3(CC-92480)
- mezigdomide
- Mezigdomide
- MEZIGDOMIDE
- MEZIGDOMIDE (CC-92480)
- mezigdomide \[INN\]
- MEZIGDOMIDE \[USAN\]
- Mezigdomide \[WHO-DD\]
- mezigdomide cc 92480
- mezigdomide inn
- mezigdomide usan
- mezigdomide who dd

## Identifiers

**CAS registry numbers**

- 2259648-80-9

**ChEMBL ID**

CHEMBL4648616

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

**InChIKey**

YTINZZFBHWSAGL-NDEPHWFRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4648616)

**PubChem compound IDs**

- 137379043

**FDA ingredient codes (UNII)**

- LA88IH4O02

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mezigdomide

**Type**

Synthetic organic

**Drug name stem**

\-domide

### Mechanisms of action

- **Action**  
Binding

**Action type**  
Binding

**Target**  
cereblon

**Gene symbol**  
CRBN

**Protein identifier**  
Q96SW2

**Median affinity**

7.52

**Affinity units**  
pIC50

### Investigated indications (3)

- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674

### Open Targets indications (6)

- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0010643

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018874

**Highest recorded phase**  
1

### Reported adverse events

- **Event**  
plasma cell myeloma refractory

**Reports**  
1

**Reporting signal score**

10.3391

### Trial references (13)

- NCT02343042  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02343042)
- NCT03374085  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03374085)
- NCT03989414  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03989414)
- NCT05372354  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05372354)
- NCT05519085  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05519085)
- NCT05552976  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05552976)
- NCT05981209  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05981209)
- NCT06048250  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06048250)
- NCT06050512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06050512)
- NCT06121843  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06121843)
- NCT06163898  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06163898)
- NCT05707390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05707390)
- NCT06318676  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06318676)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

105.98

**Calculated partition coefficient (ALogP)**

3.36

**Calculated partition coefficient (XLogP)**

2.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

42

**Molecular formula**

C32H30FN5O4

**Monoisotopic mass**

567.22818262

**Natural product**

No

## Evidence counts

**Recorded assays**

94

**Active assays**

5

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Solubility

**Median**

90

**Mean**

90

**Minimum**

90

**Maximum**

90

**Unit**

ug/mL

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

38

**Mean**

38

**Minimum**

38

**Maximum**

38

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (28)

- A Safety, PK and Efficacy Study of CC-92480 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
- [A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma](https://trialight.com/data/trial/a-study-of-an-mmset-inhibitor-in-patients-with-relapsed-and-e941247a-c4a5-45cc-922a-23e060447e45.md)
- A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment
- A Study of Revumenib and Mezigdomide in People With Leukemia
- A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma
- [A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations](https://trialight.com/data/trial/a-study-to-assess-change-in-disease-activity-and-adverse-0c89a22e-9bd3-4d81-adc9-ea130724e718.md)
- A Study to Assess Safety, Tolerability, and Pharmacokinetics of CC-92480 Formulations in Healthy Adult Participants
- A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants
- A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
- A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
- A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma
- A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
- A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
- A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
- A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment
- A Study to Evaluate the Metabolism and Excretion of \[14C\]-CC-92480 in Healthy Male Participants
- [A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-effectiveness-and-tolerable-bf2618cc-f052-43c0-a005-bd672213d933.md)
- Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies
- Expanded Access for Mezigdomide
- Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma

### In development for (3)

- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 3

---

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