> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mevrometostat-7574cda2-c099-4c18-af42-b95d00ab7170
> Record changed: 2026-10-13

# Mevrometostat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

**Drug name**

Mevrometostat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

**Molecular weight**

467.35

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

**Structure (SMILES)**

COc1cc(C)\[nH\]c(=O)c1CN1CCc2c(Cl)cc(\[C@H\](OC)C3COC3)c(Cl)c2C1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

### Other names (14)

- Mervometostat (PF-06821497)
- mervometostat pf 06821497
- mevrometostat
- Mevrometostat
- mevrometostat \[INN\]
- MEVROMETOSTAT \[USAN\]
- Mevrometostat \[WHO-DD\]
- mevrometostat inn
- mevrometostat usan
- mevrometostat who dd
- Oral PF-06821497
- pf 06821497
- Pf-06821497
- PF-06821497

## Identifiers

**CAS registry numbers**

- 1844849-10-0

**ChEMBL ID**

CHEMBL4080228

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

**InChIKey**

RXCVUHMIWHRLDF-HXUWFJFHSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4080228)

**PubChem compound IDs**

- 118572065

**FDA ingredient codes (UNII)**

- S4L4MM20B6

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mevrometostat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
enhancer of zeste 2 polycomb repressive complex 2 subunit

**Gene symbol**  
EZH2

**Protein identifier**  
Q15910

**Median affinity**  
10

**Affinity units**  
pKi

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018906

**Highest recorded phase**  
1

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

80.86

**Calculated partition coefficient (ALogP)**

3.53

**Calculated partition coefficient (XLogP)**

2.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

31

**Molecular formula**

C22H24Cl2N2O5

**Monoisotopic mass**

466.1062273

**Natural product**

No

## Evidence counts

**Recorded assays**

195

**Active assays**

10

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

1.9

**Mean**

1.9

**Minimum**

1.9

**Maximum**

1.9

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Solubility

**Median**

315

**Mean**

315

**Minimum**

315

**Maximum**

315

**Unit**

ug/mL

**Assays**

2

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

## Related records

### Trials (7)

- A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
- A Study of Mevrometostat With Enzalutamide in People With Prostate Cancer Who Have Previously Received Androgen Receptor Pathway Inhibitor Therapy
- A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
- A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
- A Study to Learn How the Medicine Called \[14C\] PF-06821497 is Taken up Into and Removed From the Body.
- A Study to Understand the Effect of Tablet Formulation and Food on PF-06821497 in Healthy Adult Participants.
- [This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.](https://trialight.com/data/trial/this-study-will-explore-whether-a-combination-of-the-425daf93-6ed3-473a-b146-292feda09d21.md)

### In development for (5)

- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1
- [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 1
- Neoplasm Phase 1
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 1

---

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