> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mevidalen-5d8f93b3-ecf1-4121-9f3e-d2dc63c1793a
> Record changed: 2026-10-13

# Mevidalen

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

**Drug name**

Mevidalen

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

**Molecular weight**

450.41

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

**Structure (SMILES)**

C\[C@H\]1c2cccc(CCC(C)(C)O)c2C\[C@H\](CO)N1C(=O)Cc1c(Cl)cccc1Cl

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

### Other names (13)

- ly 3154207
- LY-3154207
- ly3154207
- Ly3154207
- LY3154207
- LY3154207 Capsule
- LY3154207 Tablet
- mevidalen
- Mevidalen
- mevidalen \[INN\]
- MEVIDALEN \[USAN\]
- mevidalen inn
- mevidalen usan

## Identifiers

**CAS registry numbers**

- 1638667-79-4

**ChEMBL ID**

CHEMBL3421729

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

**InChIKey**

XHCSBQBBGNQINS-DOTOQJQBSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3421729)

**PubChem compound IDs**

- 86290953

**FDA ingredient codes (UNII)**

- 4A3702A96F

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mevidalen

**Type**

Synthetic organic

**Drug name stem**

\-dalen

### Mechanisms of action (2)

- **Mechanism**  
Dopamine D1 receptor positive allosteric modulator

**Action type**  
POSITIVE\_ALLOSTERIC\_MODULATOR

**Target**  
D(1A) dopamine receptor

**Protein identifier**  
P21728
- **Action**  
Positive

**Action type**  
POSITIVE

**Target**  
D1 receptor

**Gene symbol**  
DRD1

**Protein identifier**  
P21728

**Median affinity**

8.64

**Affinity units**  
pEC50

**Primary target**  
Yes

### Open Targets mechanisms

- **Mechanism**  
Dopamine D1 receptor positive allosteric modulator

**Action type**  
POSITIVE ALLOSTERIC MODULATOR

**Target**  
D(1A) dopamine receptor

### Investigated indications (3)

- **Condition**  
Lewy Body Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0006792

**Subject identifier**  
D020961
- **Condition**  
Alzheimer Disease

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004975

**Subject identifier**  
D000544
- **Condition**  
Parkinson Disease

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005180

**Subject identifier**  
D010300

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0006792

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001627

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005180

**Highest recorded phase**  
2

### Trial references (2)

- NCT02562768  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02562768)
- NCT03305809  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03305809)

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

2

**Polar surface area**

60.77

**Calculated partition coefficient (ALogP)**

4.75

**Calculated partition coefficient (XLogP)**

4.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

30

**Molecular formula**

C24H29Cl2NO3

**Monoisotopic mass**

449.1524492

**Natural product**

No

## Evidence counts

**Recorded assays**

111

**Active assays**

10

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (8)

- A Drug Interaction Study of LY3154207 in Healthy Participants
- A Study of LY3154207 in Healthy Participants
- A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
- A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated With Idiopathic Parkinson's Disease (PD) or Dementia With Lewy Bodies (DLB)
- A Study of LY3154207 on Sleep in Healthy Male Participants
- [A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease](https://trialight.com/data/trial/a-study-of-mevidalen-ly3154207-in-participants-with-6f76a20e-ba34-4d48-bc91-3592fae0e925.md)
- A Study to Evaluate LY3154207 on the Brain of Healthy Participants
- Study of LY3154207 in Healthy Participants

### In development for (3)

- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 1
- [Lewy body dementia](https://trialight.com/data/condition/lewy-body-dementia-eaa4788b-4d65-5d2f-add5-502d935893c0.md) Phase 2
- [Parkinson disease](https://trialight.com/data/condition/parkinson-disease-a117728d-ad75-551b-9b20-fffa9a2305ac.md) Phase 1

### Targets (1)

- [DRD1](https://trialight.com/data/target/drd1-368a14c8-391b-5d59-8cde-2c48da15a9c1.md) Dopamine D1 receptor positive allosteric modulator

---

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