> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d
> Record changed: 2026-10-13

# Methotrexate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

First approval year

1953

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

## Development status

**First approval year**

1953

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**Drug name**

Methotrexate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**Molecular weight**

454.45

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**Structure (SMILES)**

CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N\[C@@H\](CCC(=O)O)C(=O)O)cc1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

### Brand names (24)

- ebetrex
- Ebetrex
- emtexate high pot
- Emtexate high-pot
- emtexate pf
- Emtexate pf
- jylamvo
- Jylamvo
- maxtrex
- Maxtrex
- metoject
- Metoject
- nordimet
- Nordimet
- otrexup
- Otrexup
- otrexup pfs
- Otrexup pfs
- rasuvo
- Rasuvo
- reditrex
- Reditrex
- zlatal
- Zlatal

### Other names (77)

- (r)-methotrexate
- 3g mtx
- 3g MTX
- 5g MTX
- adx 2191
- ADX-2191
- amethopterin
- Amethopterin
- cl 14377
- CL 14377
- CL-14377
- Continue IS (MTX)
- d amethopterin
- d methotrexate
- D-amethopterin
- D-methotrexate
- emt 25299
- EMT-25299
- HD- Methotrexate (MTX)
- jylamvo
- Jylamvo
- Low-dose methotrexate (MTX)
- methotrexate
- Methotrexate
- METHOTREXATE \[EP MONOGRAPH\]

And 52 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 59-05-2

**ChEMBL ID**

CHEMBL34259

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**InChIKey**

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

**PubChem compound IDs**

- 126941

**RxNorm IDs (RxCUI)**

- 6851

**FDA ingredient codes (UNII)**

- YL5FZ2Y5U1

### ATC classification codes (2)

- L01BA01
- L04AX03

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL34259)

## Regulatory information

### United States

**Applicant**

COSETTE

**Approval date**

11 Oct 2013

**Application number**

NDA204824

### European Union

**Status**

Authorised

**Status date**

18 Aug 2016

**Authorisation date**

18 Aug 2016

**Approved indications**

Nordimet is indicated for the treatment of: active rheumatoid arthritis in adult patients, polyarthritic forms of severe, active juvenile idiopathic arthritis (JIA), when the response to nonsteroidal anti-inflammatory drugs (NSAIDs) has been inadequate, moderate to severe plaque psoriasis in adults who are candidates for systemic therapy, and severe psoriatic arthritis in adult patients, induction of remission in moderate steroid-dependent Crohn's disease in adult patients, in combination with corticosteroids and for maintenance of remission, as monotherapy, in patients who have responded to methotrexate.

**Product number**

EMEA/H/C/003983

**Authorisation holder**

Nordic Group B.V.

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Arthritis, Juvenile Rheumatoid
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Psoriasis

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/nordimet)

### Other regulatory facts

**Patents**

18

**Designations**

4

**Earliest recorded loss of exclusivity**

28 Oct 2035

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

methotrexate

**Type**

Synthetic organic

**Drug name stem**

\-trexate

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral
- Parenteral

### Mechanisms of action (4)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
dihydrofolate reductase

**Gene symbol**  
DHFR

**Protein identifier**  
P00374

**Median affinity**

8.92

**Affinity units**  
pKi

**Primary target**  
Yes
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
high mobility group box 1

**Gene symbol**  
HMGB1

**Protein identifier**  
P09429

**Median affinity**

7.62

**Affinity units**  
pKd
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Reduced folate transporter 1

**Gene symbol**  
SLC19A1

**Protein identifier**  
P41440

**Median affinity**

5.33

**Affinity units**  
pKi
- **Mechanism**  
Dihydrofolate reductase inhibitor

**Action type**  
Inhibitor

**Target**  
Dihydrofolate reductase

**Protein identifier**  
P00374

### Open Targets mechanisms

- **Mechanism**  
Dihydrofolate reductase inhibitor

**Action type**  
Inhibitor

**Target**  
Dihydrofolate reductase

### DrugCentral mechanisms

- **Action type**  
Inhibitor

**Gene symbol**  
DHFR

**Protein identifier**  
P00374

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (165)

- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D015456
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D054198
- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Lymphoma, B-Cell, Marginal Zone

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000191

**Subject identifier**  
D018442
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Neoplasms, Plasma Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000200

**Subject identifier**  
D054219
- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000209

**Subject identifier**  
D015456
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Leukemia, Erythroblastic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000218

**Subject identifier**  
D004915
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000220

**Subject identifier**  
D054198
- **Condition**  
Leukemia, Monocytic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000221

**Subject identifier**  
D007948
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Leukemia, Myelomonocytic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000223

**Subject identifier**  
D015479
- **Condition**  
Leukemia, Promyelocytic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000224

**Subject identifier**  
D015473
- **Condition**  
Immunoblastic Lymphadenopathy

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000255

**Subject identifier**  
D007119
- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Leukemia, Myelogenous, Chronic, BCR-ABL Positive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000339

**Subject identifier**  
D015464
- **Condition**  
Crohn Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000384

**Subject identifier**  
D003424
- **Condition**  
Melanoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545

And 140 more, listed on the interactive page.

### Open Targets indications (334)

- **Condition identifier**  
EFO\_0000181

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000198

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000220
- **Condition identifier**  
EFO\_0000222

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000305
- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000384

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000398
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000540
- **Condition identifier**  
EFO\_0000565

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000612
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000637

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000658

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000676
- **Condition identifier**  
EFO\_0000685
- **Condition identifier**  
EFO\_0000691

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000706

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000707

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0001068

**Highest recorded phase**  
1

And 309 more, listed on the interactive page.

### Warnings (10)

- **Warning**  
Black Box Warning

**Effect**  
carcinogenicity
- **Warning**  
Black Box Warning

**Effect**  
dermatological toxicity
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity
- **Warning**  
Black Box Warning

**Effect**  
hepatotoxicity
- **Warning**  
Black Box Warning

**Effect**  
infectious disease
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity
- **Warning**  
Black Box Warning

**Effect**  
respiratory toxicity
- **Warning**  
Black Box Warning

**Effect**  
teratogenicity
- **Warning**  
Black Box Warning

**Effect**  
vascular toxicity

### Open Targets warnings (10)

- **Warning**  
Black Box Warning

**Effect**  
carcinogenicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
dermatological toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
gastrointestinal toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hematological toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
hepatotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
infectious disease

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
nephrotoxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
respiratory toxicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
teratogenicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
vascular toxicity

**Country**  
United States

### Reported adverse events (39)

- **Event**  
abdominal discomfort

**Reports**  
5,008

**Reporting signal score**  
4,600.74
- **Event**  
alopecia

**Reports**  
6,186

**Reporting signal score**  
6,729.83
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
1,369

**Reporting signal score**  
3,485.42
- **Event**  
arthralgia

**Reports**  
9,338

**Reporting signal score**  
5,140.75
- **Event**  
arthritis

**Reports**  
2,336

**Reporting signal score**  
1,887.04
- **Event**  
arthropathy

**Reports**  
4,034

**Reporting signal score**  
5,462.95
- **Event**  
c-reactive protein abnormal

**Reports**  
1,423

**Reporting signal score**  
3,363.29
- **Event**  
c-reactive protein increased

**Reports**  
2,380

**Reporting signal score**  
2,416.13
- **Event**  
condition aggravated

**Reports**  
6,558

**Reporting signal score**  
2,946.44
- **Event**  
drug hypersensitivity

**Reports**  
9,021

**Reporting signal score**  
5,878.69
- **Event**  
drug intolerance

**Reports**  
11,306

**Reporting signal score**  
18,174.7
- **Event**  
febrile neutropenia

**Reports**  
3,069

**Reporting signal score**  
2,206.37
- **Event**  
gastrointestinal disorder

**Reports**  
2,770

**Reporting signal score**  
2,425.29
- **Event**  
glossodynia

**Reports**  
2,133

**Reporting signal score**  
3,981.38
- **Event**  
hand deformity

**Reports**  
2,276

**Reporting signal score**  
5,284.82
- **Event**  
hepatic enzyme increased

**Reports**  
3,755

**Reporting signal score**  
3,844.21
- **Event**  
infection

**Reports**  
4,446

**Reporting signal score**  
3,129.14
- **Event**  
joint swelling

**Reports**  
7,835

**Reporting signal score**  
10,619.3
- **Event**  
liver function test increased

**Reports**  
1,984

**Reporting signal score**  
2,625.07
- **Event**  
loss of personal independence in daily activities

**Reports**  
2,177

**Reporting signal score**  
3,142.83
- **Event**  
musculoskeletal stiffness

**Reports**  
4,108

**Reporting signal score**  
4,102.3
- **Event**  
pain

**Reports**  
9,599

**Reporting signal score**  
3,982.49
- **Event**  
pancytopenia

**Reports**  
2,688

**Reporting signal score**  
2,031.82
- **Event**  
pemphigus

**Reports**  
2,608

**Reporting signal score**  
6,185.79
- **Event**  
peripheral swelling

**Reports**  
3,972

**Reporting signal score**  
2,368.38

And 14 more, listed on the interactive page.

### Trial references (850)

- NCT00000361  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000361)
- NCT00000658  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000658)
- NCT00283985  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00283985)
- NCT00610883  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00610883)
- NCT00928018  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00928018)
- NCT01516580  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01516580)
- NCT04514393  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04514393)
- NCT05583071  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05583071)
- NCT05998642  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05998642)
- NCT00000834  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000834)
- NCT00001498  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001498)
- NCT00002498  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002498)
- NCT00002542  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002542)
- NCT00002579  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002579)
- NCT00002580  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002580)
- NCT00002581  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002581)
- NCT00002582  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002582)
- NCT00002696  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002696)
- NCT00002755  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002755)
- NCT00002784  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002784)
- NCT00003012  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003012)
- NCT00003013  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003013)
- NCT00003536  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003536)
- NCT00003577  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003577)
- NCT00003680  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003680)

And 825 more, listed on the interactive page.

## Dosing

**Dose**

7.5 mg

**Route**

Intramuscularly

**How often**

Once weekly

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

5

**Polar surface area**

210.54

**Calculated partition coefficient (ALogP)**

0.27

**Calculated partition coefficient (XLogP)**

\-1.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

9

**Heavy atoms**

33

**Molecular formula**

C20H22N8O5

**Monoisotopic mass**

454.17131583

**Natural product**

Yes

## National Drug Codes

- 0143-9367
- 0143-9516
- 0143-9517
- 0143-9518
- 0143-9519
- 0143-9830
- 0904-7141
- 16729-277
- 50268-554
- 54436-010
- 54436-012
- 54436-015
- 54436-017
- 54436-020
- 54436-022
- 54436-025
- 68382-775
- 81927-204
- 52652-2001
- 70771-1058

## Evidence counts

**Recorded assays**

13,674

**Active assays**

4,907

### Active assay types (4)

- Confirmatory
- Other
- Screening
- Summary

## Pharmacologic actions

- Abortifacient Agents, Nonsteroidal  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000020.html)
- Antimetabolites, Antineoplastic  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000964.html)
- Dermatologic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html)
- Enzyme Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D004791.html)
- Folic Acid Antagonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D005493.html)
- Immunosuppressive Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007166.html)
- Antirheumatic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018501.html)
- Nucleic Acid Synthesis Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D019384.html)

## Biological measurements

These details could not be displayed.

## Related records

### Trials (1,425)

- "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"
- \[CREMA\]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 2-week dc of MTX and Influenza Vaccination in RA
- 4 x Epirubicin, Cyclophosphamide, Followed by 4 x Docetaxel Versus 6 x CMF / 6 x CEF
- 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer
- 506U78 in Treating Patients With Refractory Hematologic Cancer
- A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.
- A Bioavailability Study of Methotrexate 25 mg Administered by Needle Injection and a Pre Filled Needle-free Device in Healthy Volunteers.
- A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis
- A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
- A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)
- A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）
- A Clinical Trial Evaluating Patients With Primary Vitreoretinal Lymphoma
- A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours
- A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects
- A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).
- A Clinical Trial Using Metronomic Oral Low-dose Cyclophosphamide Alternating With Low-dose Oral Methotrexate With Continuous Celecoxib and Weekly Vinblastine in Children and Adolescents With Relapsed or Progressing soliD Tumours.
- A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
- A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate

### Approved for (19)

- Acute lymphoblastic leukemia
- [Arthritic joint disease](https://trialight.com/data/condition/arthritic-joint-disease-594ede40-773b-5c20-afc1-eb18dabbe039.md)
- B-cell acute lymphoblastic leukemia
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md)
- Breast carcinoma
- [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md)
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Childhood acute lymphoblastic leukemia
- [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md)
- Juvenile idiopathic arthritis
- Lymphoblastic lymphoma
- [Mycosis fungoides](https://trialight.com/data/condition/mycosis-fungoides-dfed1f75-762a-528c-b446-218ae612379e.md)
- Neoplasm
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md)
- Palmoplantar pustulosis
- Polyarticular arthritis
- [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md)
- [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md)
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md)

### In development for (143)

- [Acquired polycythemia vera](https://trialight.com/data/condition/acquired-polycythemia-vera-5c3132a8-49a0-5b93-b3d6-cd5f1fa9e10e.md) Phase 2
- Acute erythroid leukemia Phase 3
- Acute graft versus host disease Phase 3
- Acute leukemia of ambiguous lineage Phase 3
- Acute megakaryoblastic leukemia Phase 3
- Acute monocytic leukemia Phase 3
- Acute myeloblastic leukemia without maturation Phase 3
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 3
- Acute myelomonocytic leukemia M4 Phase 3
- Acute promyelocytic leukemia Phase 3
- Adult T-cell leukemia/lymphoma Phase 2
- [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 3
- Anaplastic large cell lymphoma Phase 3
- [Angioimmunoblastic T-cell lymphoma](https://trialight.com/data/condition/angioimmunoblastic-t-cell-lymphoma-5b697108-b9cf-53e9-afde-71a36bf55d6b.md) Phase 2
- [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md) Phase 3
- Aplastic anemia Phase 3
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3
- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2
- Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Phase 2

### Other linked conditions (8)

- Childhood leukemia
- Common wart
- [Diabetic macular edema](https://trialight.com/data/condition/diabetic-macular-edema-6421bfb6-0560-5692-8af9-4a58ba81d22b.md)
- Fasciitis
- [Inflammatory bowel disease](https://trialight.com/data/condition/inflammatory-bowel-disease-619080ac-2d43-5ad3-b078-9699e1241655.md)
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md)
- T-cell non-Hodgkin lymphoma
- Type 1 diabetes mellitus

### Targets (1)

- [DHFR](https://trialight.com/data/target/dhfr-e77e5dcd-f4e0-5e26-b456-0a5b230a72b3.md) Dihydrofolate reductase inhibitor

---

## A note for AI agents

You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
- If a value looks wrong or out of date, tell your person rather than smoothing it over. Registries lag, and so can we.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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- Ask your person before signing them up for anything.
- Reading, quoting and citing these pages is welcome.