> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0 > Record changed: 2026-10-13 # Metformin hydrochloride Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) First approval year 1995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) ## Development status **First approval year** 1995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **Drug name** Metformin hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **Molecular weight** 165.63 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **Structure (SMILES)** CN(C)C(=N)NC(=N)N.Cl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) ### Brand names (74) - bolamyn sr - Bolamyn sr - diagemet xl - Diagemet xl - fortamet - Fortamet - glucamet 500 - Glucamet 500 - glucamet 850 - Glucamet 850 - glucient sr - Glucient sr - glucophage - Glucophage - glucophage sr - Glucophage sr - glucophage xr - Glucophage xr - glumetza - Glumetza - glyformin - Glyformin - ledermetin - Ledermetin - metabet sr And 49 more, listed on the interactive page. ### Other names (103) - 2 x 500 mg Metformin (Glumetza) - 2 x 500 mg metformin glumetza - 2x500 mg Metformin (Glumetza) - 3x500 mg Metformin (Glumetza) - 500 mg Glucophage XR® - actoplus met component metformin hydrochloride - ACTOPLUS MET COMPONENT METFORMIN HYDROCHLORIDE - apophage - Apophage - benofomin - Benofomin - diabefagos - Diabefagos - diabex - Diabex - ex 404 - EX-404 - ex404 - EX404 - glucaminol - Glucaminol - Glucophage - Glucophage 1000 mg - Glucophage 1000mg - Glucophage 500mg And 78 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1115-70-4 **ChEMBL ID** CHEMBL1703 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **InChIKey** OETHQSJEHLVLGH-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1703) **RxNorm IDs (RxCUI)** - 235743 **FDA ingredient codes (UNII)** - 786Z46389E ### PubChem compound IDs (6) - 14219 - 43833340 - 53630812 - 137346479 - 137704554 - 176517462 ## Regulatory information ### United States **Applicant** RANBAXY **Approval date** 11 Sept 2003 **Application number** NDA021591 ### Other regulatory facts **Patents** 1 **Designations** 1 **Earliest recorded loss of exclusivity** 1 May 2035 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Drug name stem** \-formin #### Administration routes - Oral ### Mechanisms of action (51) - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O00217 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O00483 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O14561 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O15239 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43181 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43674 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43676 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43677 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43678 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O43920 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O75251 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O75306 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O75380 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O75438 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O75489 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95139 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95167 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95168 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95169 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95178 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95182 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95298 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O95299 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** O96000 - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) **Protein identifier** P03886 And 26 more, listed on the interactive page. ### Open Targets mechanisms (2) - **Mechanism** Mitochondrial complex I (NADH dehydrogenase) inhibitor **Action type** Inhibitor **Target** Mitochondrial complex I (NADH dehydrogenase) - **Mechanism** Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor **Action type** Inhibitor **Target** Glycerol-3-phosphate dehydrogenase, mitochondrial ### Investigated indications (54) - **Condition** Metabolic Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000195 **Subject identifier** D024821 - **Condition** Squamous Cell Carcinoma of Head and Neck **Highest recorded phase** 2 **Condition identifier** EFO:0000199 **Subject identifier** D000077195 - **Condition** Adenocarcinoma, Clear Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000348 **Subject identifier** D018262 - **Condition** Diabetes Mellitus **Highest recorded phase** 4 **Condition identifier** EFO:0000400 **Subject identifier** D003920 - **Condition** Carcinoma, Intraductal, Noninfiltrating **Highest recorded phase** 2 **Condition identifier** EFO:0000432 **Subject identifier** D002285 - **Condition** Carcinoma, Endometrioid **Highest recorded phase** 2 **Condition identifier** EFO:0000466 **Subject identifier** D018269 - **Condition** Glioblastoma **Highest recorded phase** 1 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Infertility **Highest recorded phase** 2 **Condition identifier** EFO:0000545 **Subject identifier** D007246 - **Condition** Adenocarcinoma of Lung **Highest recorded phase** 2 **Condition identifier** EFO:0000571 **Subject identifier** D000077192 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Polycystic Ovary Syndrome **Highest recorded phase** 2 **Condition identifier** EFO:0000660 **Subject identifier** D011085 - **Condition** Prostatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000673 **Subject identifier** D011471 - **Condition** Lung Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001071 **Subject identifier** D008175 - **Condition** Obesity **Highest recorded phase** 2 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Ovarian Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001075 **Subject identifier** D010051 - **Condition** Multiple Myeloma **Highest recorded phase** 1 **Condition identifier** EFO:0001378 **Subject identifier** D009101 - **Condition** Prostatic Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0001663 **Subject identifier** D011471 - **Condition** Glucose Intolerance **Highest recorded phase** 3 **Condition identifier** EFO:0002546 **Subject identifier** D018149 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Heart Failure **Highest recorded phase** 2 **Condition identifier** EFO:0003144 **Subject identifier** D006333 - **Condition** Mouth Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0003868 **Subject identifier** D009062 - **Condition** Renal Insufficiency, Chronic **Highest recorded phase** 3 **Condition identifier** EFO:0003884 **Subject identifier** D051436 - **Condition** Vitiligo **Highest recorded phase** 2 **Condition identifier** EFO:0004208 **Subject identifier** D014820 - **Condition** Aortic Aneurysm, Abdominal **Highest recorded phase** 2 **Condition identifier** EFO:0004214 **Subject identifier** D017544 And 29 more, listed on the interactive page. ### Open Targets indications (78) - **Condition identifier** EFO\_0000195 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000199 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000348 - **Condition identifier** EFO\_0000400 - **Condition identifier** EFO\_0000545 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000660 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000673 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001071 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001073 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001378 **Highest recorded phase** 1 - **Condition identifier** EFO\_0002546 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002618 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003868 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003884 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004208 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004214 - **Condition identifier** EFO\_0004593 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004616 - **Condition identifier** EFO\_0006859 - **Condition identifier** EFO\_0008520 **Highest recorded phase** 2 - **Condition identifier** EFO\_0008522 **Highest recorded phase** 2 - **Condition identifier** EFO\_0022597 **Highest recorded phase** 3 And 53 more, listed on the interactive page. ### Warnings (4) - **Warning** Black Box Warning **Effect** cardiotoxicity - **Warning** Black Box Warning **Effect** metabolic toxicity - **Warning** Black Box Warning **Effect** respiratory toxicity - **Warning** Black Box Warning **Effect** vascular toxicity ### Open Targets warnings (4) - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States - **Warning** Black Box Warning **Effect** metabolic toxicity **Country** United States - **Warning** Black Box Warning **Effect** respiratory toxicity **Country** United States - **Warning** Black Box Warning **Effect** vascular toxicity **Country** United States ### Reported adverse events (31) - **Event** acute kidney injury **Reports** 5,353 **Reporting signal score** 8,975.62 - **Event** anuria **Reports** 479 **Reporting signal score** 949.981 - **Event** blood glucose increased **Reports** 1,324 **Reporting signal score** 1,431.6 - **Event** blood lactic acid increased **Reports** 341 **Reporting signal score** 723.886 - **Event** dehydration **Reports** 1,124 **Reporting signal score** 555.703 - **Event** diabetes mellitus inadequate control **Reports** 852 **Reporting signal score** 1,820.93 - **Event** diabetic ketoacidosis **Reports** 970 **Reporting signal score** 1,468.92 - **Event** diabetic metabolic decompensation **Reports** 237 **Reporting signal score** 699.426 - **Event** diarrhoea **Reports** 3,276 **Reporting signal score** 919.044 - **Event** euglycaemic diabetic ketoacidosis **Reports** 330 **Reporting signal score** 737.463 - **Event** glycosylated haemoglobin increased **Reports** 574 **Reporting signal score** 981.004 - **Event** haemodialysis **Reports** 371 **Reporting signal score** 579.065 - **Event** hyperglycaemia **Reports** 868 **Reporting signal score** 1,105.51 - **Event** hyperkalaemia **Reports** 1,542 **Reporting signal score** 2,511.56 - **Event** hyperlactacidaemia **Reports** 426 **Reporting signal score** 1,231.31 - **Event** hypoglycaemia **Reports** 3,075 **Reporting signal score** 6,479.05 - **Event** hypoglycaemic coma **Reports** 394 **Reporting signal score** 1,028.87 - **Event** hypotension **Reports** 1,691 **Reporting signal score** 674.675 - **Event** hypothermia **Reports** 426 **Reporting signal score** 662.12 - **Event** ketoacidosis **Reports** 412 **Reporting signal score** 844.539 - **Event** lactic acidosis **Reports** 8,664 **Reporting signal score** 30,366 - **Event** metabolic acidosis **Reports** 2,668 **Reporting signal score** 6,468.23 - **Event** pancreatitis acute **Reports** 574 **Reporting signal score** 590.711 - **Event** pemphigoid **Reports** 442 **Reporting signal score** 829.48 - **Event** renal failure **Reports** 1,448 **Reporting signal score** 1,305.47 And 6 more, listed on the interactive page. ### Trial references (108) - NCT00005669 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00005669) - NCT00209482 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00209482) - NCT03051451 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03051451) - NCT00035542 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00035542) - NCT00035568 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00035568) - NCT00290940 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00290940) - NCT00449930 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00449930) - NCT00482729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00482729) - NCT00499707 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00499707) - NCT00532935 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00532935) - NCT00541450 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00541450) - NCT00612144 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00612144) - NCT00660907 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00660907) - NCT00680745 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00680745) - NCT00830076 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00830076) - NCT00859898 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00859898) - NCT00865033 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00865033) - NCT00882882 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00882882) - NCT00897390 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00897390) - NCT00929201 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00929201) - NCT00961480 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00961480) - NCT00961857 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00961857) - NCT01002807 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01002807) - NCT01269996 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01269996) - NCT01386671 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01386671) And 83 more, listed on the interactive page. ## Dosing **Dose** 50 mg sitagliptin and 500 mg metformin HCl **Route** Oral **How often** Twice daily ### Conditions of use - Do not split or divide tablets ## Chemical properties **Hydrogen bond acceptors** 2 **Hydrogen bond donors** 4 **Polar surface area** 88.99 **Calculated partition coefficient (ALogP)** \-1.03 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 0 **Heavy atoms** 10 **Molecular formula** C4H12ClN5 **Monoisotopic mass** 165.0781231 **Natural product** No ## National Drug Codes - 0006-0078 - 0006-0080 - 0006-0081 - 0006-0575 - 0006-0577 - 0006-5369 - 0006-5370 - 0006-5373 - 0006-5374 - 0093-7455 - 0093-7456 - 0093-7457 - 0310-6225 - 0310-6250 - 0310-6260 - 0310-6270 - 0310-6280 - 0378-6001 - 0378-6002 - 0378-7185 - 0378-7186 - 0378-7187 - 0378-8175 - 0378-8176 - 0378-8177 And 595 more, listed on the interactive page. ## Evidence counts **Recorded assays** 1,468 **Active assays** 9 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Hypoglycemic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D007004.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** \-6.13 **Mean** \-6.13 **Minimum** \-6.13 **Maximum** \-6.13 **Unit** unitless **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Oral bioavailability **Median** 59 **Mean** 58 **Minimum** 50 **Maximum** 64 **Unit** % **Assays** 4 **Standard deviation** 5.83095 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (2,082) - "Hepatic Substrate Flux Rates in Type 2 Diabetes" - "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome - 1% Metformin Gel in the Treatment of Class II Furcation Defects - 1% Metformin in Moderate and Severe Periodontitis - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) - 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period - A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers - A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers. - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration ### Approved for (2) - [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) ### In development for (48) - Abdominal aortic aneurysm Phase 2 - Brain ischemia Phase 1 - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3 - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 3 - Clear cell adenocarcinoma Phase 1 - Diabetic neuropathy Phase 1 - Ductal breast carcinoma in situ Phase 2 - [Endometrial carcinoma](https://trialight.com/data/condition/endometrial-carcinoma-d0794a04-ff16-5af6-8fb7-7b3d6bd6c537.md) Phase 2 - Endometrioid adenocarcinoma Phase 2 - Exocrine pancreatic carcinoma Phase 1 - [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2 - Fanconi anemia Phase 2 - Gestational diabetes Phase 3 - Glioblastoma Phase 1 - Gliosarcoma Phase 1 - Glucose intolerance Phase 3 - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Early phase 1 - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 2 - Hyperinsulinism Phase 2 - Infertility disorder Phase 2 ### Other linked conditions (2) - [Osteoarthritis](https://trialight.com/data/condition/osteoarthritis-e8c428fb-1597-576d-bcf0-f3b27ebc6a00.md) - Precocious puberty ### Targets (51) - [COXFA4](https://trialight.com/data/target/coxfa4-7d75e29a-decc-5e87-b2d6-1ac11b00ba7c.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [COXFA4L2](https://trialight.com/data/target/coxfa4l2-74460d10-783f-506a-826c-ada6b04395f0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [GPD2](https://trialight.com/data/target/gpd2-4ef823da-c09f-5600-bf22-d4201ee4de3c.md) Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor - [MT-ND1](https://trialight.com/data/target/mt-nd1-da56bfa6-9109-5230-9fab-1feb175e18e8.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND2](https://trialight.com/data/target/mt-nd2-05bc86a7-c29a-59a5-933e-abc1f52bf9cd.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND3](https://trialight.com/data/target/mt-nd3-65ff2fc6-2cee-522f-b556-952089a8ccbb.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND4](https://trialight.com/data/target/mt-nd4-6174af49-88e7-5f62-b9eb-b1d21888b5dd.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND4L](https://trialight.com/data/target/mt-nd4l-bd147784-576b-5e87-8df0-1b70bcbb0d8f.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND5](https://trialight.com/data/target/mt-nd5-78e4779d-c75a-5b40-9e0d-21b79ac1230f.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [MT-ND6](https://trialight.com/data/target/mt-nd6-351e625f-2043-541e-b898-671764f99a8e.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA1](https://trialight.com/data/target/ndufa1-cd940f95-7d60-5194-8f72-29194a2a5e02.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA10](https://trialight.com/data/target/ndufa10-1a66e96a-a0ea-538c-aeda-78dc367fa80e.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA11](https://trialight.com/data/target/ndufa11-1ab92f5e-4b24-5365-8e25-3bf9ca99a0ff.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA12](https://trialight.com/data/target/ndufa12-f8b18d37-f6ac-50db-98db-4994cb7ef1ee.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA13](https://trialight.com/data/target/ndufa13-87ddc7f8-fee4-57e0-b37b-0ab5701328bc.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA2](https://trialight.com/data/target/ndufa2-6ca72a5d-dea8-548e-a4ce-1b6de2e1d8e0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA3](https://trialight.com/data/target/ndufa3-da9c6eb6-b797-5f4c-bb35-4e45eb9969d8.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA5](https://trialight.com/data/target/ndufa5-fb8b84cc-087c-5f08-a326-25b7997fc873.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA6](https://trialight.com/data/target/ndufa6-83c7eea0-1cb0-58c8-8845-3c8bcb218ee7.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - [NDUFA7](https://trialight.com/data/target/ndufa7-399c1d4e-7814-566d-84ba-03ac053ba8d6.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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