> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/mazdutide-e5f082bd-5031-49c0-81ec-410796ee2192
> Record changed: 2026-10-13

# Mazdutide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

**Drug name**

Mazdutide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

### Other names (19)

- ibi 362
- Ibi-362
- ibi362
- Ibi362
- IBI362
- ly 3305677
- LY-3305677
- ly3305677
- LY3305677
- mazdutida
- Mazdutida
- mazdutide
- Mazdutide
- mazdutide \[INN\]
- MAZDUTIDE \[USAN\]
- Mazdutide \[WHO-DD\]
- mazdutide inn
- mazdutide usan
- mazdutide who dd

## Identifiers

**CAS registry numbers**

- 2259884-03-0

**ChEMBL ID**

CHEMBL5095358

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095358)

**FDA ingredient codes (UNII)**

- MB76Z4IBZ5

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

mazdutide

**Type**

Peptide

**Drug name stem**

\-tide

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (4)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**

7.64

**Affinity units**  
pKi
- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
glucagon receptor

**Gene symbol**  
GCGR

**Protein identifier**  
P47871

**Median affinity**

7.84

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**

7.62

**Affinity units**  
pEC50
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
glucagon receptor

**Gene symbol**  
GCGR

**Protein identifier**  
P47871

**Median affinity**

8.14

**Affinity units**  
pEC50

### Investigated indications (5)

- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Obesity

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003095

**Subject identifier**  
D065626
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (17)

- **Condition identifier**  
EFO\_0000400
- **Condition identifier**  
EFO\_0000660
- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003086

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003095
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001627

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002046

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005015
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007027

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007147

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008487

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0013209

### Trial references (12)

- NCT03928379  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03928379)
- NCT04466904  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04466904)
- NCT04965506  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04965506)
- NCT05606913  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05606913)
- NCT05628311  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05628311)
- NCT04440345  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04440345)
- NCT04773977  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04773977)
- NCT04904913  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04904913)
- NCT05607680  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05607680)
- NCT05623839  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05623839)
- NCT05815680  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05815680)
- NCT05793450  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05793450)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (3)

- **Component**  
Sequence

**Type**  
Protein

**Sequence**  
HX1QGTFTSDYSKYLDEKKAX2EFVEWLLEGGPSSX3
- **Component**  
Modified residues

**Sequence**  
X2(SMILES):CC(C)(N)C=O
- **Component**  
Modified residues

**Sequence**  
X3(SMILES):NCC(N)=O

## Related records

### Trials (40)

- [A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight](https://trialight.com/data/trial/a-master-protocol-study-ly900038-of-multiple-intervention-4fb412a0-6f78-4d87-8cc3-1da7b8ea4edb.md)
- A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and Obesity
- A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD）
- A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
- A Study of IBI362 9 mg in Chinese Adults With Obesity
- A Study of IBI362 Evaluating Weight Loss in Obese and Overweight Chinese Subjects
- A Study of IBI362 in Chinese Adolescents With Obesity or Overweight
- A Study of IBI362 in Chinese Patients With Type 2 Diabetes
- A Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2
- A Study of IBI362 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH)
- A Study of IBI362 in Participants With Obesity or Overweight
- A Study of IBI362 in Participants With Type 2 Diabetes
- A Study of IBI362 in Poorly Controlled Type 2 Diabetes Patients Only Through Diet and Exercise
- A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity
- A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight
- A Study of LY3305677 in Healthy Participants
- A Study of LY3305677 in Participants With Obesity Or Overweight
- A Study of LY3305677 in Participants With Type 2 Diabetes
- A Study of Multiple Doses of LY3305677 in Healthy Participants
- [A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder](https://trialight.com/data/trial/a-study-to-evaluate-mazdutide-compared-with-placebo-in-c7c6096f-de34-47a2-b41f-0e6018073689.md)

### In development for (6)

- [Alcohol abuse](https://trialight.com/data/condition/alcohol-abuse-de2eaa0d-f882-51b6-befd-e62533fe8ee1.md) Phase 2
- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 1
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 1
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 3
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3

### Other linked conditions (1)

- Polycystic ovary syndrome

---

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