> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64 > Record changed: 2026-10-13 # Mavacamten Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) First approval year 2022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) ## Development status **First approval year** 2022 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **Drug name** Mavacamten Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **Molecular weight** 273.34 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **Structure (SMILES)** CC(C)n1c(=O)cc(N\[C@@H\](C)c2ccccc2)\[nH\]c1=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) ### Brand names (2) - camzyos - Camzyos ### Other names (19) - camzyos - Camzyos - Camzyos (Mavacamten) - camzyos mavacamten - mavacamten - Mavacamten - Mavacamten \[INN\] - Mavacamten \[MI\] - Mavacamten \[USAN\] - Mavacamten \[WHO-DD\] - mavacamten inn - mavacamten mi - mavacamten usan - mavacamten who dd - myk 461 - Myk-461 - MYK-461 - sar 439152 - SAR-439152 ## Identifiers **CAS registry numbers** - 1642288-47-8 **ChEMBL ID** CHEMBL4297517 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **InChIKey** RLCLASQCAPXVLM-NSHDSACASA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) **PubChem compound IDs** - 117761397 **RxNorm IDs (RxCUI)** - 2600867 **FDA ingredient codes (UNII)** - QX45B99R3J ### ATC classification codes (2) - C01EB - C01EB24 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297517) ## Regulatory information ### United States **Applicant** BRISTOL **Approval date** 28 Apr 2022 **Application number** NDA214998 ### European Union **Status** Authorised **Status date** 26 Jun 2023 **Authorisation date** 26 Jun 2023 **Approved indications** Treatment of symptomatic obstructive hypertrophic cardiomyopathy. **Product number** EMEA/H/C/005457 **Authorisation holder** Bristol-Myers Squibb Pharma EEIG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Cardiomyopathy, Hypertrophic European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/camzyos) ### Other regulatory facts **Patents** 2 **Designations** 4 **Earliest recorded loss of exclusivity** 28 Apr 2036 **First in class** Yes **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** mavacamten **Type** Synthetic organic **Drug name stem** \-camten **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (7) - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** A7E2Y1 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** P08590 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** P10916 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** P12829 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** P12883 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** P13533 - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin **Protein identifier** Q01449 ### Open Targets mechanisms - **Mechanism** Cardiac myosin inhibitor **Action type** Inhibitor **Target** Cardiac myosin ### Investigated indications (3) - **Condition** Cardiovascular Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Cardiomyopathy, Hypertrophic **Highest recorded phase** 4 **Condition identifier** EFO:0000538 **Subject identifier** D002312 - **Condition** Heart Failure **Highest recorded phase** 2 **Condition identifier** EFO:0003144 **Subject identifier** D006333 ### Open Targets indications (8) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0000538 - **Condition identifier** EFO\_0000556 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 2 - **Condition identifier** HP\_0000822 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005045 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 2 ### Warnings - **Warning** Black Box Warning **Effect** cardiotoxicity ### Open Targets warnings - **Warning** Black Box Warning **Effect** cardiotoxicity **Country** United States ### Reported adverse events (4) - **Event** anticholinergic effect **Reports** 2 **Reporting signal score** 22.0102 - **Event** drug interaction **Reports** 9 **Reporting signal score** 20.1075 - **Event** left ventricular dysfunction **Reports** 3 **Reporting signal score** 12.4393 - **Event** left ventricular outflow tract gradient increased **Reports** 1 **Reporting signal score** 10.989 ### Trial references (14) - NCT02329184 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02329184) - NCT02842242 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02842242) - NCT03442764 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03442764) - NCT03470545 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03470545) - NCT03496168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03496168) - NCT03723655 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03723655) - NCT04349072 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04349072) - NCT05135871 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05135871) - NCT05174416 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05174416) - NCT05414175 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05414175) - NCT05582395 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05582395) - NCT06112743 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06112743) - NCT06253221 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06253221) - NCT04766892 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04766892) ## Dosing **Dose** 5 mg **Route** Oral **How often** Once daily ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 2 **Polar surface area** 66.89 **Calculated partition coefficient (ALogP)** 2.29 **Calculated partition coefficient (XLogP)** 2.1 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 20 **Molecular formula** C15H19N3O2 **Monoisotopic mass** 273.147726857 **Natural product** No ## National Drug Codes - 73625-111 - 73625-112 - 73625-113 - 73625-114 ## Evidence counts **Recorded assays** 52 **Active assays** 12 ### Active assay types - Confirmatory ## Biological measurements ### Observed measurements #### Liver toxicity assay **Median** 3,650 **Mean** 3,650 **Minimum** 2,200 **Maximum** 5,100 **Unit** nM **Assays** 2 **Standard deviation** 2,050.61 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - EC50 ## Related records ### Trials (41) - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) - A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT - A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants - A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy - A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants - A Study to Evaluate the Effects of Mavacamten in Healthy Participants - [A Study to Evaluate the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants](https://trialight.com/data/trial/a-study-to-evaluate-the-effects-on-the-single-dose-drug-9959bc8f-cbf9-46f9-9324-9902a772314a.md) - A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM ### Approved for (2) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - [Hypertrophic cardiomyopathy](https://trialight.com/data/condition/hypertrophic-cardiomyopathy-2bcaf1dc-551c-50d7-8f5b-4b8457815d3c.md) ### In development for (1) - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 2 ### Targets (7) - [MYH6](https://trialight.com/data/target/myh6-097541bf-6e40-5a4e-ba06-2181f90fa6ad.md) Cardiac myosin inhibitor - [MYH7](https://trialight.com/data/target/myh7-09047b93-12ca-546a-9e75-b4c26f6800ab.md) Cardiac myosin inhibitor - [MYH7B](https://trialight.com/data/target/myh7b-e6e9d41f-3a08-55fb-a499-d3fd03dc5854.md) Cardiac myosin inhibitor - [MYL2](https://trialight.com/data/target/myl2-f5014294-503a-583e-9f48-65c04786cdc4.md) Cardiac myosin inhibitor - [MYL3](https://trialight.com/data/target/myl3-c9ae4776-336f-5b78-9518-e74ae4a55b07.md) Cardiac myosin inhibitor - [MYL4](https://trialight.com/data/target/myl4-79a2244f-ffbf-5b90-9021-e71c6659cfd5.md) Cardiac myosin inhibitor - [MYL7](https://trialight.com/data/target/myl7-92a64fdb-05b7-5beb-8db8-1f144e932487.md) Cardiac myosin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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