> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/matrix-m1-adjuvant-dd338ac7-2b84-460a-965a-9861e0f3c500 > Record changed: 2026-10-13 # Matrix-M1 adjuvant Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650407) Drug type Unknown ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650407) ## Names and chemistry **Drug type** Unknown **Drug name** Matrix-M1 adjuvant Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650407) ### Other names (9) - matrix m - Matrix M - matrix m1 adjuvant - Matrix-m - Matrix-M - Matrix-m1 adjuvant - Matrix-M1 Adjuvant - Matrix-M1™ adjuvant - Matrix-M™ ## Identifiers **ChEMBL ID** CHEMBL4650407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650407) **FDA ingredient codes (UNII)** - YZ7P8Y8ECX ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (7) - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Malaria **Highest recorded phase** 3 **Condition identifier** EFO:0001068 **Subject identifier** D008288 - **Condition** Hemorrhagic Fever, Ebola **Highest recorded phase** 1 **Condition identifier** EFO:0007243 **Subject identifier** D019142 - **Condition** Influenza, Human **Highest recorded phase** 2 **Condition identifier** EFO:0007328 **Subject identifier** D007251 - **Condition** Malaria, Falciparum **Highest recorded phase** 2 **Condition identifier** EFO:0007444 **Subject identifier** D016778 - **Condition** Respiratory Syncytial Virus Infections **Highest recorded phase** 2 **Condition identifier** EFO:1001413 **Subject identifier** D018357 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (7) - **Condition identifier** EFO\_0000694 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001068 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007243 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007328 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007444 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001413 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Trial references (23) - NCT02370589 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02370589) - NCT02925403 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02925403) - NCT03970993 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03970993) - NCT04704830 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04704830) - NCT05155579 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05155579) - NCT05913973 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05913973) - NCT03026348 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03026348) - NCT03658629 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03658629) - NCT03896724 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03896724) - NCT03947190 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03947190) - NCT04271306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04271306) - NCT04318002 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04318002) - NCT05135273 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05135273) - NCT05252845 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05252845) - NCT05357560 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05357560) - NCT04368988 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04368988) - NCT04533399 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04533399) - NCT04611802 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04611802) - NCT04961541 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04961541) - NCT05372588 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05372588) - NCT05468736 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05468736) - NCT05875701 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05875701) - NCT06291857 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06291857) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ## Related records ### Trials (41) - A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults - A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults - A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom - A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK - A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine) - A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M - A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21 - A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines - A Study to Compare Two Dosing Regimens for a New Malaria Vaccine - A Study to Determine if a New Malaria Vaccine is Safe and Induces Immunity Among Kenyan Adults, Young Children and Infants - A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults - A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2 - [A Study to Evaluate the Safety and Immunogenicity of COVID-19 and Influenza Combination Vaccine](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-and-immunogenicity-of-covid-6aadabe5-f3e0-4f16-afb7-fcdd6e12a2eb.md) - [A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-and-immunogenicity-of-covid-f0b18c6a-897d-47c0-85cd-3cc759a64d26.md) - A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso. - A(H7N9) VLP Antigen Dose-Ranging Study With Matrix-M1™ Adjuvant - Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines - Assessment of Safety and Immunogenicity of R21/Matrix-M™ in African Children Living With HIV - Dose Finding Trial of R21/Matrix-M in School Children - Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-typhoidal Salmonella Disease ### In development for (7) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - Ebola hemorrhagic fever Phase 1 - [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 2 - [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 3 - [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) Phase 2 - [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md) Phase 2 - [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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