> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/maridebart-ffa8c60f-308f-4787-8615-cd76d5c717f7 > Record changed: 2026-10-13 # Maridebart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) **Drug name** Maridebart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) ### Other names (16) - AMG 133 mAb (PARENT) - amg 133 mab parent - amg 133 parent - AMG-133 (PARENT) - gamma1 heavy chain Homo sapiens (1-450) \[VH (Homo sapiens IGHV3-33\*01 (92.9%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v64 CH2 C36, G1v54-30 CH2 C83, G84.4, C85 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 E36>C (275), R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12(359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-15\*01 (97.9%) -IGKJ4\*01(100%), CDR-IMGT \[6.3.9\] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - gamma1 heavy chain homo sapiens 1 450 vh homo sapiens ighv3 33 01 92 9 ighd ighj4 01 100 cdr imgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 g1v64 ch2 c36 g1v54 30 ch2 c83 g84 4 c85 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 e36 c 275 r83 c 295 n84 4 g 300 v85 c 305 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 15 01 97 9 igkj4 01 100 cdr imgt 6 3 9 27 32 51 53 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - immunoglobulin g1 anti glucose dependent insulinotropic polypeptide receptor 275 cysteine 295 cysteine 300 glycine 305 cysteine human γ1 chain disulfide with human κ chain dimer - immunoglobulin g1 kappa anti homo sapiens gipr gastric inhibitory polypeptide receptor homo sapiens monoclonal antibody gamma1 heavy chain homo sapiens 1 450 vh homo sapiens ighv3 33 01 92 9 ighd ighj4 01 100 cdrimgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 g1v64 ch2 c36 g1v54 30 ch2 c83 g84 4 c85 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 e36 c 275 r83 c 295 n84 4 g 300 v85 c 305 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with kappa light chain homo sapiens 1 214 vkappa homo sapiens igkv3 15 01 97 9 igkj4 01 100 cdr imgt 6 3 9 27 32 51 53 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - Immunoglobulin G1-kappa, anti-\[Homo sapiens GIPR (gastric inhibitory polypeptide receptor)\], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-450) \[VH (Homo sapiens IGHV3-33\*01 (92.9%)-(IGHD) -IGHJ4\*01 (100%), CDRIMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v64 CH2 C36, G1v54-30 CH2 C83, G84.4, C85 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 E36>C (275), R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') \[VKAPPA (Homo sapiens IGKV3-15\*01 (97.9%) -IGKJ4\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - Immunoglobulin G1, anti-(glucose-dependent insulinotropic polypeptide receptor) \[275-cysteine,295-cysteine,300-glycine,305-cysteine\] (human γ1-chain), disulfide with human κ-chain, dimer - maridebart - Maridebart - maridebart \[INN\] - MARIDEBART \[USAN\] - maridebart inn - maridebart usan ## Identifiers **CAS registry numbers** - 2761478-99-1 **ChEMBL ID** CHEMBL5314750 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314750) **FDA ingredient codes (UNII)** - 76AFN9QO5H ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** maridebart cafraglutide **Type** Antibody **Drug name stem** \-bart ### Mechanisms of action (2) - **Action type** Agonist **Target** GLP-1 receptor **Gene symbol** GLP-1 receptor - **Action type** Antagonist **Target** GIP receptor **Gene symbol** GIP receptor ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGEGLEWVAAIWFDASDKYYADAVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQAIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPCVKENWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** EIVMTOSPATLSVSPGERATLSCRASQSVSSNLAWYOQKPGQAPRLLIYGAATRATGIPARVSGSGSGTEFTLTISSLOSEDFAVYYCQQYNNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 295-305 $ 295''-305'' $ 370-428 $ 370''-428'' - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' ## Related records ### Trials (152) - A Glucometabolic Evaluation of Patients With Idiopathic Ketotic Hypoglycemia - A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) - A Single-dose Cross-over Study to Assess Direct and Indirect Effects of Dapagliflozin on Pancreatic Alpha and Beta Cells in Patients With Type 2 Diabetes - A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese - A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus - A Study to Evaluate a Potassium Normalization Treatment Regimen Including Sodium Zirconium Cyclosilicate (ZS) Among Patients With S-K ≥5.8 - A Study to Evaluate AMG 133 Administered Subcutaneously in Participants With Overweight or Obesity - A Study to Evaluate AMG 133 in Participants With Varying Degrees of Hepatic Impairment or Normal Hepatic Function - [A Trial to Assess Bioavailability of AMG 133 in Participants With Overweight or Obesity](https://trialight.com/data/trial/a-trial-to-assess-bioavailability-of-amg-133-in-participants-a81bad38-0386-497c-86a9-9530847edcfd.md) - A Trial to Assess the Effect of Kidney Impairment on How AMG 133 is Absorbed, Broken Down, and Eliminated by the Body - A Trial to Evaluate Interactions Between Antiemetic Medication and AMG 133 in Participants Living With Overweight or Obesity - Add-on Sodium Nitroprusside to Treatment as Usual in Schizophrenia - ADD-ON Study to Existing Hypoparathyroidism Studies - Analgesic Effect of Oral 25% Glucose Versus Oral 24% Sucrose for Pain Relief During Heel Lance in Preterm Neonates - Analgesic Efficacy of Oral Glucose in Preterm Neonates During Suctioning - Antioxidation Medication for Noise-induced Hearing Loss - Assessing Brain Metabolism Using MRS With Deuterated Glucose - Autonomic Nervous System Reactivity of the Newborn After a Nociceptive Stress: Interest of Sucrose and Non-nutritive Sucking - Behavioral Parent Training With and Without AI Support for Children With Disruptive Behaviors - Beta Cell Function in (Pre) Type 1 Diabetes --- ## A note for AI agents You are probably reading this for a person. 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