> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/maridebart-cafraglutide-ed4d163f-9dd6-42fa-9ba3-bc4358617867 > Record changed: 2026-10-13 # Maridebart cafraglutide Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) **Drug name** Maridebart cafraglutide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) ### Other names (20) - amg 133 - AMG 133 - AMG-133 - gamma1 heavy chain Homo sapiens (1-450) \[VH (Homo sapiens IGHV3-33\*01 (92.9%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v64 CH2 C36, G1v54-30 CH2 C83, G84.4, C85 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 E36>C (275), R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-15\*01 (97.9%)-IGKJ4\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; 275,275''-bis(thioether) conjugated to a glucagon-like peptide 1(GLP-1) analogue (GCG (glucagon) 98-126, GLP-1 7-35 A8>methylalanine (2), V16>Y (10), G22>E (16)), via a fused 18-mer linker (diglycyl- tris(tetraglycyl-seryl)-lysinamide - gamma1 heavy chain homo sapiens 1 450 vh homo sapiens ighv3 33 01 92 9 ighd ighj4 01 100 cdr imgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 g1v64 ch2 c36 g1v54 30 ch2 c83 g84 4 c85 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 e36 c 275 r83 c 295 n84 4 g 300 v85 c 305 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 15 01 97 9 igkj4 01 100 cdr imgt 6 3 9 27 32 51 53 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa 275 275 bis thioether conjugated to a glucagon like peptide 1 glp 1 analogue gcg glucagon 98 126 glp 1 7 35 a8 methylalanine 2 v16 y 10 g22 e 16 via a fused 18 mer linker diglycyl tris tetraglycyl seryl lysinamide - immunoglobulin g1 anti glucose dependent insulinotropic polypeptide receptor 275 cysteine 295 cysteine 300 glycine 305 cysteine human γ1 chain disulfide with human κ chain dimer - immunoglobulin g1 anti glucose dependent insulinotropic polypeptide receptor 275 cysteine 295 cysteine 300 glycine 305 cysteine human γ1 chain disulfide with human κ chain dimer 275 275 bis thioether with 7 37 glucagon like peptide i 8 2 methylalanine 16 tyrosine 22 glutamic acid 36 glycine human fusion protein with peptide linker ggggs 3 n6 2 mercaptoacetyl lysinamide - immunoglobulin g1 kappa anti homo sapiens gipr gastric inhibitory polypeptide receptor homo sapiens monoclonal antibody gamma1 heavy chain homo sapiens 1 450 vh homo sapiens ighv3 33 01 92 9 ighd ighj4 01 100 cdrimgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 g1v64 ch2 c36 g1v54 30 ch2 c83 g84 4 c85 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 e36 c 275 r83 c 295 n84 4 g 300 v85 c 305 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with kappa light chain homo sapiens 1 214 vkappa homo sapiens igkv3 15 01 97 9 igkj4 01 100 cdr imgt 6 3 9 27 32 51 53 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - Immunoglobulin G1-kappa, anti-\[Homo sapiens GIPR (gastric inhibitory polypeptide receptor)\], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-450) \[VH (Homo sapiens IGHV3-33\*01 (92.9%)-(IGHD) -IGHJ4\*01 (100%), CDRIMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v64 CH2 C36, G1v54-30 CH2 C83, G84.4, C85 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 E36>C (275), R83>C (295), N84.4>G (300), V85>C (305) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') \[VKAPPA (Homo sapiens IGKV3-15\*01 (97.9%) -IGKJ4\*01 (100%), CDR-IMGT \[6.3.9\] (27-32.51-53.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - Immunoglobulin G1, anti-(glucose-dependent insulinotropic polypeptide receptor) \[275-cysteine,295-cysteine,300-glycine,305-cysteine\] (human γ1-chain), disulfide with human κ-chain, dimer - Immunoglobulin G1, anti-(glucose-dependent insulinotropic polypeptide receptor) \[275-cysteine,295-cysteine,300-glycine,305-cysteine\] (human γ1-chain), disulfide with human κ-chain, dimer, 275,275′-bis(thioether) with 7-37-glucagon-like peptide I \[8-(2-methylalanine),16-tyrosine,22-glutamic acid,36-glycine\] (human) fusion protein with peptide linker ((GGGGS)3-N6-(2-mercaptoacetyl)lysinamide) - maridebart cafraglutida - Maridebart cafraglutida - maridebart cafraglutide - Maridebart cafraglutide - Maridebart Cafraglutide - maridebart cafraglutide \[INN\] - MARIDEBART CAFRAGLUTIDE \[USAN\] - maridebart cafraglutide inn - maridebart cafraglutide usan ## Identifiers **CAS registry numbers** - 2760218-55-9 **ChEMBL ID** CHEMBL5314751 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314751) **FDA ingredient codes (UNII)** - Z24U3U73HN ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** maridebart cafraglutide **Type** Antibody **Drug name stem** \-bart; -tide ### Mechanisms of action (2) - **Action** Agonist **Action type** Agonist **Target** GLP-1 receptor **Gene symbol** GLP1R **Protein identifier** P43220 **Median affinity** 7.61 **Affinity units** pEC50 - **Action** Antagonist **Action type** Antagonist **Target** GIP receptor **Gene symbol** GIPR **Protein identifier** P48546 **Median affinity** 7.37 **Affinity units** pIC50 ### Open Targets indications (7) - **Condition identifier** EFO\_0001073 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003918 **Highest recorded phase** 3 - **Condition identifier** HP\_0001513 **Highest recorded phase** 3 - **Condition identifier** HP\_0025502 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0007147 **Highest recorded phase** 3 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGEGLEWVAAIWFDASDKYYADAVKGRETISRDNSKNTLYLQMNSLRAEDTAVYYCARDQAIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPCVKENWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 295-305 $ 295''-305'' $ 370-428 $ 370''-428'' - **Component** Light chain **Type** Protein **Sequence** EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPLTEGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' ## Related records ### Trials (20) - [A Study of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus (T2DM)](https://trialight.com/data/trial/a-study-of-maridebart-cafraglutide-in-adult-participants-a4b4a7f3-685e-4968-8c22-ce0ed4ba6024.md) - A Study to Evaluate AMG 133 in Chinese Participants With Obesity or Overweight - A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus - [A Trial to Compare the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous Presentations](https://trialight.com/data/trial/a-trial-to-compare-the-extent-to-which-maridebart-2aec3dbb-5cc3-4176-b454-59ceb574cf59.md) - A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight - [Comparing the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous (SC) Presentations](https://trialight.com/data/trial/comparing-the-extent-to-which-maridebart-cafraglutide-amg-08ed24ce-e84a-4705-878b-7c5ba6dcff09.md) - [Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus](https://trialight.com/data/trial/dose-ranging-study-to-evaluate-the-efficacy-safety-and-54860093-dded-4c2f-b140-7c413bb69a11.md) - Effect of Maridebart Cafraglutide on How Oral Contraceptives Are Absorbed and Processed in the Body in Postmenopausal Female Participants Living With Overweight or Obesity - Effect of Maridebart Cafraglutide on the Heart's Electrical Activity - Efficacy and Safety of Maridebart Cafraglutide in Adult Participants in Japan Who Have Obesity Disease - [Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight](https://trialight.com/data/trial/efficacy-and-safety-of-maridebart-cafraglutide-in-adult-ec2bf21b-f077-41a7-994f-e832c5420f1b.md) - Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH) - [Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity](https://trialight.com/data/trial/evaluating-the-impact-of-maridebart-cafraglutide-on-6e9aea5b-a80d-42fe-bffa-31b1e0f28f6f.md) - [Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight](https://trialight.com/data/trial/evaluation-of-maridebart-cafraglutide-in-adult-participants-97c4eea5-5fa4-4a8c-b2da-6f99efa8feb4.md) - [Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)](https://trialight.com/data/trial/extension-trial-to-evaluate-the-long-term-efficacy-safety-d63a70a7-a8f3-4637-9424-579a36de4650.md) - Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION) - [Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity](https://trialight.com/data/trial/maridebart-cafraglutide-in-heart-failure-with-preserved-or-779a3acb-bec0-4f44-83c7-bab6bc0d306b.md) - Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy - Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy - Single and Multiple Ascending Dose Study of AMG 133 in Participants With Obesity ### In development for (3) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 3 - [Obstructive sleep apnea syndrome](https://trialight.com/data/condition/obstructive-sleep-apnea-syndrome-02928491-a2d7-50f4-a4b7-30b79e6771ff.md) Phase 3 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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