> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/maribavir-d159b255-857b-4919-a860-55850975c16a > Record changed: 2026-10-13 # Maribavir Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) First approval year 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) ## Development status **First approval year** 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **Drug name** Maribavir Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **Molecular weight** 376.24 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **Structure (SMILES)** CC(C)Nc1nc2cc(Cl)c(Cl)cc2n1\[C@H\]1O\[C@@H\](CO)\[C@H\](O)\[C@@H\]1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) ### Brand names (2) - livtencity - Livtencity ### Other names (24) - 1263 w 94 - 1263-W-94 - 1263w94 - 1263W94 - bw 1263w94 - BW-1263W94 - gw 257406x - GW-257406X - livtencity - Livtencity - LIVTENCITY - maribavir - Maribavir - Maribavir (200 mg) - Maribavir (400 mg) - Maribavir (800 mg) - Maribavir \[INN\] - Maribavir \[MI\] - Maribavir \[USAN\] - Maribavir \[WHO-DD\] - maribavir inn - maribavir mi - maribavir usan - maribavir who dd ## Identifiers **ATC classification codes** - J05AX10 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **CAS registry numbers** - 176161-24-3 **ChEMBL ID** CHEMBL515408 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **InChIKey** KJFBVJALEQWJBS-XUXIUFHCSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL515408) **PubChem compound IDs** - 471161 **RxNorm IDs (RxCUI)** - 2586068 **FDA ingredient codes (UNII)** - PTB4X93HE1 ## Regulatory information ### United States **Applicant** TAKEDA PHARMS USA **Approval date** 23 Nov 2021 **Application number** NDA215596 ### European Union **Status** Authorised **Status date** 9 Nov 2022 **Authorisation date** 9 Nov 2022 **Approved indications** LIVTENCITY is indicated for the treatment of cytomegalovirus (CMV) infection and/or disease that are refractory (with or without resistance) to one or more prior therapies, including ganciclovir, valganciclovir, cidofovir or foscarnet in adult patients who have undergone a haematopoietic stem cell transplant (HSCT) or solid organ transplant (SOT). Consideration should be given to official guidance on the appropriate use of antiviral agents. **Product number** EMEA/H/C/005787 **Authorisation holder** Takeda Pharmaceuticals International AG Ireland Branch **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Cytomegalovirus Infections European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/livtencity) ### Other regulatory facts **Patents** 7 **Designations** 5 **Earliest recorded loss of exclusivity** 11 Oct 2043 **First in class** Yes **Fast track** No **Breakthrough designation** Yes **Orphan designation** Yes **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** maribavir **Type** Synthetic organic **Drug name stem** \-vir **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (2) - **Mechanism** Phosphotransferase pUL97 inhibitor **Action type** Inhibitor **Target** Serine/threonine protein kinase UL97 **Protein identifier** P16788 - **Mechanism** Serine/threonine-protein kinase BGLF4 inhibitor **Action type** Inhibitor **Target** Serine/threonine-protein kinase BGLF4 **Protein identifier** P0C731 ### Open Targets mechanisms (2) - **Mechanism** Phosphotransferase pUL97 inhibitor **Action type** Inhibitor **Target** Serine/threonine protein kinase UL97 - **Mechanism** Serine/threonine-protein kinase BGLF4 inhibitor **Action type** Inhibitor **Target** Serine/threonine-protein kinase BGLF4 ### Investigated indications (2) - **Condition** Virus Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Cytomegalovirus Infections **Highest recorded phase** 4 **Condition identifier** EFO:0001062 **Subject identifier** D003586 ### Open Targets indications (6) - **Condition identifier** EFO\_0000763 - **Condition identifier** EFO\_0001062 - **Condition identifier** MONDO\_0005062 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005108 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005132 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0009693 **Highest recorded phase** 2 ### Reported adverse events (10) - **Event** bronchopulmonary aspergillosis **Reports** 3 **Reporting signal score** 13.133 - **Event** cytomegalovirus chorioretinitis **Reports** 3 **Reporting signal score** 16.1511 - **Event** cytomegalovirus infection **Reports** 6 **Reporting signal score** 24.2266 - **Event** cytomegalovirus infection reactivation **Reports** 5 **Reporting signal score** 28.8859 - **Event** drug resistance **Reports** 9 **Reporting signal score** 36.1918 - **Event** escherichia sepsis **Reports** 3 **Reporting signal score** 15.3096 - **Event** febrile neutropenia **Reports** 6 **Reporting signal score** 15.9496 - **Event** infectious pleural effusion **Reports** 3 **Reporting signal score** 17.1949 - **Event** neurological decompensation **Reports** 3 **Reporting signal score** 16.4449 - **Event** pathogen resistance **Reports** 4 **Reporting signal score** 16.6424 ### Trial references (10) - NCT00223925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00223925) - NCT00411645 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00411645) - NCT00497796 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00497796) - NCT01611974 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01611974) - NCT02775240 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02775240) - NCT02927067 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02927067) - NCT02931539 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02931539) - NCT05137717 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05137717) - NCT05319353 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05319353) - NCT06439342 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06439342) ## Dosing **Dose** 400 mg **Route** Oral **How often** Twice daily ### Conditions of use - Take with or without food ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 4 **Polar surface area** 99.77 **Calculated partition coefficient (ALogP)** 1.77 **Calculated partition coefficient (XLogP)** 2.2 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 24 **Molecular formula** C15H19Cl2N3O4 **Monoisotopic mass** 375.0752615 **Natural product** Yes ## National Drug Codes - 64764-800 ## Evidence counts **Recorded assays** 275 **Active assays** 16 ### Active assay types - Confirmatory ## Pharmacologic actions - Antiviral Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000998.html) ## Related records ### Trials (188) - A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder. - A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression - A Dose Ranging Study to Evaluate the Safety and Efficacy of GSK2586184 in Patients With Chronic Plaque Psoriasis - A Long-term Efficacy and Safety of NTQ5082 Capsules - A Multiple-Dose Study to Evaluate MK-1075 in Hepatitis C Virus (HCV) Infected Participants (MK-1075-004) - A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings - A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis - A Phase 2 Study of Hemay007 in Patients With Rheumatoid Arthritis - A Phase 2A Study of a Novel Antimalarial Pyrrolidinamide in Adult Patients With Uncomplicated P. Falciparum Malaria - A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD - A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP) - A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus - A Phase I Study of GFH312 in Healthy Chinese Subjects - A Phase III Study of NTQ5082 Capsules in the Treatment of Paroxysmal Nocturnal Hemoglobinuria Patients - A Prospective Single-Arm Observational Study of Maribavir for the Treatment of Post Hematopoietic Stem Cell Transplantation Cytomegalovirus Infection - A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer - A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse - A Safety, Tolerability and Preliminary Efficacy Study of LiRIS® 400 mg in Women With Interstitial Cystitis (IC) and Hunner's Lesions - A Single Rising Dose Study of MK-8150 (MK-8150-001) - A Study Comparing the Pharmacokinetics and Palatability of Two Candidate Pediatric Powder-for-Oral-Suspension Formulations of Maribavir to the Current Maribavir Tablet Formulation Administered in Healthy Adult Participants ### Approved for (2) - [Cytomegalovirus infection](https://trialight.com/data/condition/cytomegalovirus-infection-33aa640c-a359-5979-84a0-c70ac00df24d.md) - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) --- ## A note for AI agents You are probably reading this for a person. 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