> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/maraviroc-deed9596-32e8-46a6-9f95-23f7bfd66f33 > Record changed: 2026-10-13 # Maraviroc Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) First approval year 2007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) ## Development status **First approval year** 2007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **Drug name** Maraviroc Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **Molecular weight** 513.68 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **Structure (SMILES)** Cc1nnc(C(C)C)n1\[C@H\]1C\[C@H\]2CC\[C@@H\](C1)N2CC\[C@H\](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) ### Brand names (4) - celsentri - Celsentri - selzentry - Selzentry ### Other names (23) - ART intensification (maraviroc) - art intensification maraviroc - Celsentri® - CELSENTRI® Tablets - maraviroc - Maraviroc - Maraviroc (5 days) - Maraviroc (Celsentri) - Maraviroc (MVC) - Maraviroc (Part 1) - Maraviroc (Part 2) - maraviroc (Selzentry) - Maraviroc 150 MG - Maraviroc 300 mg - maraviroc endo - Maraviroc, endo- - rel maraviroc - Rel-maraviroc - Selzentry - uk 427 857 - uk 427857 - Uk-427,857 - UK-427857 ## Identifiers **ATC classification codes** - J05AX09 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **ChEMBL ID** CHEMBL256907 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **InChIKey** GSNHKUDZZFZSJB-QUMGSSFMSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL256907) **RxNorm IDs (RxCUI)** - 620216 **FDA ingredient codes (UNII)** - A3C7SRV8DV ### CAS registry numbers (2) - 376348-65-1 - 2414315-81-2 ## Regulatory information ### United States **Applicant** VIIV HLTHCARE **Approval date** 6 Aug 2007 **Application number** NDA022128 ### European Union **Status** Authorised **Status date** 18 Sept 2007 **Authorisation date** 18 Sept 2007 **Approved indications** Celsentri, in combination with other antiretroviral medicinal products, is indicated for treatment experienced adults, adolescents and children of 2 years of age and older and weighing at least 10 kg infected with only CCR5-tropic HIV-1 detectable **Product number** EMEA/H/C/000811 **Authorisation holder** ViiV Healthcare B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - HIV Infections European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/celsentri) ### Other regulatory facts **Patents** 0 **Designations** 3 **First in class** Yes **Fast track** Yes **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** Yes **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** maraviroc **Type** Synthetic organic **Drug name stem** \-vir- **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (2) - **Action** Antagonist **Action type** Antagonist **Target** CCR5 **Gene symbol** CCR5 **Protein identifier** P51681 **Median affinity** 8.1 **Affinity units** pIC50 **Primary target** Yes - **Mechanism** C-C chemokine receptor type 5 antagonist **Action type** Antagonist **Target** C-C chemokine receptor type 5 **Protein identifier** P51681 ### Open Targets mechanisms - **Mechanism** C-C chemokine receptor type 5 antagonist **Action type** Antagonist **Target** C-C chemokine receptor type 5 ### DrugCentral mechanisms - **Action type** Antagonist **Gene symbol** CCR5 **Protein identifier** P51681 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (20) - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** HIV Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000180 **Subject identifier** D015658 - **Condition** Hodgkin Disease **Highest recorded phase** 2 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 2 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Leukemia, Myelogenous, Chronic, BCR-ABL Positive **Highest recorded phase** 2 **Condition identifier** EFO:0000339 **Subject identifier** D015464 - **Condition** Lymphoma, Large B-Cell, Diffuse **Highest recorded phase** 2 **Condition identifier** EFO:0000403 **Subject identifier** D016403 - **Condition** Infections **Highest recorded phase** 3 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Sarcoma, Kaposi **Highest recorded phase** 2 **Condition identifier** EFO:0000558 **Subject identifier** D012514 - **Condition** Arthritis, Rheumatoid **Highest recorded phase** 2 **Condition identifier** EFO:0000685 **Subject identifier** D001172 - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Virus Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** HIV Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Acquired Immunodeficiency Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000765 **Subject identifier** D000163 - **Condition** AIDS Dementia Complex **Highest recorded phase** 2 **Condition identifier** EFO:0002608 **Subject identifier** D015526 - **Condition** Hypertriglyceridemia **Highest recorded phase** 1 **Condition identifier** EFO:0004211 **Subject identifier** D015228 - **Condition** Cognitive Dysfunction **Highest recorded phase** 2 **Condition identifier** HP:0100543 **Subject identifier** D060825 - **Condition** Graft vs Host Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0013730 **Subject identifier** D006086 - **Condition** Lymphoma, Follicular **Highest recorded phase** 2 **Condition identifier** MONDO:0018906 **Subject identifier** D008224 - **Condition** Hematologic Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0044881 **Subject identifier** D019337 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (35) - **Condition identifier** EFO\_0000180 - **Condition identifier** EFO\_0000180 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000558 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000685 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000712 - **Condition identifier** EFO\_0000763 - **Condition identifier** EFO\_0000764 - **Condition identifier** EFO\_0000765 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002608 - **Condition identifier** EFO\_0004211 **Highest recorded phase** 1 - **Condition identifier** EFO\_0007948 **Highest recorded phase** 2 - **Condition identifier** HP\_0001297 **Highest recorded phase** 2 - **Condition identifier** HP\_0001397 **Highest recorded phase** 2 - **Condition identifier** HP\_0001513 **Highest recorded phase** 1 - **Condition identifier** HP\_0100543 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004648 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004790 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004995 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005055 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005091 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005108 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005109 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 1 And 10 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning **Effect** hepatotoxicity ### Open Targets warnings - **Warning** Black Box Warning **Effect** hepatotoxicity **Country** United States ### Reported adverse events (41) - **Event** abortion spontaneous **Reports** 18 **Reporting signal score** 14.626 - **Event** acute myocardial infarction **Reports** 15 **Reporting signal score** 15.2234 - **Event** aids dementia complex **Reports** 3 **Reporting signal score** 14.9616 - **Event** anal cancer **Reports** 7 **Reporting signal score** 26.6617 - **Event** anogenital dysplasia **Reports** 6 **Reporting signal score** 30.6367 - **Event** blood hiv rna increased **Reports** 11 **Reporting signal score** 37.8986 - **Event** cd4 lymphocytes decreased **Reports** 7 **Reporting signal score** 18.0323 - **Event** congenital bladder anomaly **Reports** 4 **Reporting signal score** 18.5616 - **Event** congenital renal disorder **Reports** 6 **Reporting signal score** 26.9267 - **Event** congenital ureteric anomaly **Reports** 4 **Reporting signal score** 20.5797 - **Event** congenital vesicoureteric reflux **Reports** 4 **Reporting signal score** 21.3271 - **Event** csf test abnormal **Reports** 10 **Reporting signal score** 45.0144 - **Event** dermatitis exfoliative **Reports** 9 **Reporting signal score** 15.6562 - **Event** drug resistance **Reports** 33 **Reporting signal score** 59.5304 - **Event** enanthema **Reports** 8 **Reporting signal score** 31.6801 - **Event** generalised anxiety disorder **Reports** 9 **Reporting signal score** 31.961 - **Event** hepatic failure **Reports** 11 **Reporting signal score** 13.2035 - **Event** hodgkin's disease **Reports** 27 **Reporting signal score** 93.4705 - **Event** hyperbilirubinaemia **Reports** 20 **Reporting signal score** 42.3203 - **Event** hyperlipidaemia **Reports** 12 **Reporting signal score** 17.7771 - **Event** immune reconstitution inflammatory syndrome **Reports** 9 **Reporting signal score** 16.3072 - **Event** immune reconstitution syndrome **Reports** 6 **Reporting signal score** 17.3008 - **Event** kaposi's sarcoma **Reports** 9 **Reporting signal score** 21.5087 - **Event** kidney enlargement **Reports** 7 **Reporting signal score** 25.3969 - **Event** lipodystrophy acquired **Reports** 16 **Reporting signal score** 53.2507 And 16 more, listed on the interactive page. ### Trial references (85) - NCT00098293 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098293) - NCT00795444 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00795444) - NCT00993148 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00993148) - NCT01345630 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01345630) - NCT01348308 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01348308) - NCT01400412 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01400412) - NCT02486510 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02486510) - NCT00098306 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098306) - NCT00098722 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098722) - NCT00098748 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00098748) - NCT00426660 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00426660) - NCT00478231 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00478231) - NCT00496782 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00496782) - NCT00537394 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00537394) - NCT00624195 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624195) - NCT00634959 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00634959) - NCT00643643 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00643643) - NCT00703586 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00703586) - NCT00717067 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00717067) - NCT00719823 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00719823) - NCT00735072 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00735072) - NCT00771823 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00771823) - NCT00791700 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00791700) - NCT00808002 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00808002) - NCT00821535 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00821535) And 60 more, listed on the interactive page. ## Dosing **Dose** 150 mg or 300 mg or 600 mg **Route** Oral **How often** Twice daily ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 1 **Polar surface area** 63.05 **Calculated partition coefficient (ALogP)** 5.95 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 8 **Heavy atoms** 37 **Molecular formula** C29H41F2N5O **Natural product** No ## Biological measurements These details could not be displayed. ## Related records ### Trials (200) - A Clinical Study Comparing Safety and Immunogenicity of bOPV of Bilthoven Biologicals - A Compassionate Access Protocol For Those Patients Who Have Completed A4001029 - A Dose Escalation Study of Duvortuxizumab in Participants With Relapsed or Refractory B-cell Malignancies - A Drug Interaction Study Investigating the Effect of Rifabutin on the Pharmacokinetics of Maraviroc - A Feasibility Study to Assess Tenofovir and Maraviroc Protection Against HIV-1 in Cervical and Vaginal Explants - A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients. - A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID - A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients - A Open-label, Drug-Drug Interaction With Maraviroc (DDI) - A Phase 1 Study to Assess the Safety and Effects of Single and Multiple Doses of KS101 in Healthy Volunteers - A Phase I Study to Evaluate the Taste of Belumosudil Oral Suspensions & Assess Relative Bioavailability - A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer - A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy - A Pilot Study Of A Novel Treatment Regimen, Maraviroc + Ritonavir Boosted Atazanavir, In Treatment Naive HIV-Infected Patients - A Safety and Pharmacokinetic Study for Dapivirine and Maraviroc Gel in Belgium - A Single Ascending Dose Study in Healthy Participants and Multiple Ascending Dose Study of CNTO 7160 in Participants With Asthma and Participants With Atopic Dermatitis - A Study Combining Ibrutinib With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With CD20-Positive B-Cell Non Hodgkin Lymphoma - A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBV - A Study in Healthy Men to Test How BI 1265162 is Taken up and Processed by the Body - A Study in Patients With Advanced Breast Cancer ### Approved for (2) - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) ### In development for (16) - AIDS Phase 3 - AIDS dementia complex Phase 2 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 2 - Chronic myeloid leukemia Phase 2 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2 - [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 2 - Graft versus host disease Phase 2 - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) Phase 2 - Hodgkins lymphoma Phase 2 - [Hypertriglyceridemia](https://trialight.com/data/condition/hypertriglyceridemia-538285c3-ad71-513e-bd58-6cc97634acb2.md) Phase 1 - Kaposi's sarcoma Phase 2 - [Myelodysplastic syndrome](https://trialight.com/data/condition/myelodysplastic-syndrome-f5df8ce5-6064-53d3-902c-f09fc4acd4bb.md) Phase 2 - [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2 - [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 2 ### Other linked conditions (1) - [Sarcoidosis](https://trialight.com/data/condition/sarcoidosis-cdc064df-8a7a-53b8-b711-ec1830da35dd.md) ### Targets (1) - [CCR5](https://trialight.com/data/target/ccr5-257b6639-97fa-5d2a-bfa1-77a02dd259cb.md) C-C chemokine receptor type 5 antagonist --- ## A note for AI agents You are probably reading this for a person. 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