> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lutikizumab-e1d48312-4edb-4a49-84ae-7cc8a1b35e99 > Record changed: 2026-10-13 # Lutikizumab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) **Drug name** Lutikizumab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) ### Other names (17) - a 1234138 - A-1234138 - abt 981 - Abt-981 - ABT-981 - immunoglobulin anti interleukin 1β interleukin 1α synthetic human a 1234138 heavy chain disulfide with synthetic human a 1234138 light chain dimer - immunoglobulin g1 kappa anti homo sapiens il1a interleukin 1 alpha and homo sapiens il1b interleukin 1 beta il 1b 1l1f2 humanized monoclonal antibody tetravalent bispecific gamma1 heavy chain 1 577 humanized vh anti il1b homo sapiens ighv3 23 04 80 60 ighd ighj4 01 8 8 12 1 119 6 mer linker 120 125 homo sapiens vh anti il1a ighv3 30 03 88 80 ighd ighj1 01 8 8 15 126 247 homo sapiens ighg1 01 ch1 248 345 hinge 346 360 ch2 l1 3 a 364 l1 2 a 365 361 470 ch3 471 575 chs 576 577 248 577 350 327 disulfide with kappa light chain 1 327 humanized v kappa anti il1b homo sapiens igkv1 27 01 82 10 igkj2 01 6 3 9 1 106 7 mer linker homo sapiens v kappa anti il1a igkv1 12 01 92 60 igkj4 01 6 3 9 114 220 homo sapiens igkc 01 km3 221 327 dimer 356 356 359 359 bisdisulfide - Immunoglobulin G1-kappa, anti-\[Homo sapiens IL1A (interleukin 1 alpha) and Homo sapiens IL1B (interleukin 1 beta, IL-1B, 1L1F2)\], humanized monoclonal antibody, tetravalent bispecific; gamma1 heavy chain (1-577) \[humanized VH anti-IL1B (Homo sapiens IGHV3-23\*04 (80.60%) -(IGHD)-IGHJ4\*01) \[8.8.12\] (1-119) -6-mer linker (120-125)-Homo sapiens VH anti-IL1A (IGHV3-30\*03 (88.80%) -(IGHD)-IGHJ1\*01) \[8.8.15\] (126-247) -Homo sapiens IGHG1\*01 (CH1 (248- 345), hinge (346-360), CH2 L1.3>A (364), L1.2>A (365), (361-470), CH3 (471-575), CHS (576-577)) (248-577)\], (350-327')-disulfide with kappa light chain (1’-327’) \[humanized V-KAPPA anti-IL1B (Homo sapiens IGKV1- 27\*01 (82.10%) -IGKJ2\*01) \[6.3.9\] (1'-106') -7-mer linker-Homo sapiens V-KAPPA anti-IL1A (IGKV1-12\*01 (92.60%) -IGKJ4\*01) \[6.3.9\] (114'-220')-Homo sapiens IGKC\*01, Km3 (221'-327')\]; dimer (356-356":359-359")-bisdisulfide - Immunoglobulin, anti-(interleukin 1β/interleukin 1α) (synthetic human A-1234138 heavy chain), disulfide with synthetic human A-1234138 light chain, dimer - lutikizumab - Lutikizumab - lutikizumab \[INN\] - LUTIKIZUMAB \[USAN\] - Lutikizumab \[WHO-DD\] - lutikizumab inn - lutikizumab usan - lutikizumab who dd ## Identifiers **CAS registry numbers** - 1791411-57-8 **ChEMBL ID** CHEMBL4594518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594518) **FDA ingredient codes (UNII)** - 15FAZ725S0 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** lutikizumab **Type** Antibody **Drug name stem** \-mab; -mab ### Mechanisms of action (4) - **Action** Binding **Action type** Binding **Target** IL-1α **Gene symbol** IL-1α **Median affinity** 11.12 **Affinity units** pKd **Primary target** Yes - **Action** Binding **Action type** Binding **Target** IL-1β **Gene symbol** IL-1β **Median affinity** 10.68 **Affinity units** pKd **Primary target** Yes - **Mechanism** Interleukin-1 alpha inhibitor **Action type** Inhibitor **Target** Interleukin-1 alpha **Protein identifier** P01583 - **Mechanism** Interleukin-1 beta inhibitor **Action type** Inhibitor **Target** Interleukin-1 beta **Protein identifier** P01584 ### Open Targets mechanisms (2) - **Mechanism** Interleukin-1 alpha inhibitor **Action type** Inhibitor **Target** Interleukin-1 alpha - **Mechanism** Interleukin-1 beta inhibitor **Action type** Inhibitor **Target** Interleukin-1 beta ### Investigated indications (4) - **Condition** Colitis, Ulcerative **Highest recorded phase** 2 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Osteoarthritis, Knee **Highest recorded phase** 2 **Condition identifier** EFO:0004616 **Subject identifier** D020370 - **Condition** Hidradenitis Suppurativa **Highest recorded phase** 3 **Condition identifier** EFO:1000710 **Subject identifier** D017497 - **Condition** Osteoarthritis **Highest recorded phase** 1 **Condition identifier** MONDO:0005178 **Subject identifier** D010003 ### Open Targets indications (13) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004616 **Highest recorded phase** 2 - **Condition identifier** EFO\_1000710 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002400 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005178 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005416 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0006559 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0011849 **Highest recorded phase** 2 ### Trial references (5) - NCT01668511 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01668511) - NCT02087904 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02087904) - NCT05139602 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05139602) - NCT06468228 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06468228) - NCT06257875 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06257875) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (7) - **Component** Glycosylation sites (N) **Sequence** 427 $ 427'''' - **Component** Heavy chain **Type** Protein **Sequence** EVQLQESGPGLVKPSETLSLTCAVTGYSITSGYSWHWIRQFPGNGLEWMGYIHSSGSTNYNPSLKSRISISRDTSKNQFFLKLSSVTAADTAVYYCAGYDDYFEYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Glycosylation sites (N) **Sequence** 427 $ 427'' - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCKASQNVGFNVAWYQQKPGKSPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFAEYFCQQYNWYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGVVQPGRSLRLSCSASGFIFSRYDMSWVRQAPGKGLEWVAYISHGGAGTYYPDSVKGRFTISRDNSKNTLFLQMDSLRPEDTGVYFCARGGVTKGYFDVWGQGTPVTVSSASTKGPQVQLVESGGGVVQPGRSLRLSCTASGFTFSMFGVHWVRQAPGKGLEWVAAVSYDGSNKYYAESVKGRFTISRDNSKNILFLQMDSLRLEDTAVYYCARGRPKVVIPAPLAHWGQGTLVTFSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 136'-201' $ 136'''-201''' $ 147-221 $ 147''-221'' $ 247-307' $ 247''-307''' $ 274-330'' $ 274-330'' $ 350-327' $ 350''-327'' $ 356-356'' $ 359''-359'' $ 391-451 $ 391''-451'' $ 359''-359'' $ 497-555 $ 497''-555'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 143-199 $ 143''-199'' $ 219-214' $ 219''-214''' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424'' ## Related records ### Trials (12) - A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis - A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis - A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis - [A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa](https://trialight.com/data/trial/a-study-to-assess-disease-activity-and-safety-of-lutikizumab-4bcfed2a-d481-4b0f-a5a2-edbeeed3705d.md) - A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy - A Study to Assess Molecular Changes in Adult Participants With Moderate to Severe Hidradenitis Suppurativa or With Moderate to Severe Atopic Dermatitis Receiving Subcutaneous Injections of Lutikizumab - A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis - A Study to Evaluate the Effectiveness and Safety of Treatments, Either Alone or in Combination, for the Treatment of Moderate to Severe Atopic Dermatitis - A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-981 in Patients With Osteoarthritis of the Knee - Relative Bioavailability of Two Lutikizumab Formulations and Pharmacokinetics, Safety, and Tolerability of Lutikizumab in Chinese Participants - Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis - [Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease](https://trialight.com/data/trial/study-of-targeted-therapies-for-the-treatment-of-adult-fd9667f3-785e-4538-a14e-ad95e7e210eb.md) ### In development for (5) - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 3 - [Osteoarthritis](https://trialight.com/data/condition/osteoarthritis-e8c428fb-1597-576d-bcf0-f3b27ebc6a00.md) Phase 1 - [Osteoarthritis, knee](https://trialight.com/data/condition/osteoarthritis-knee-217c801b-d59c-514b-92dd-3abbf23b24d7.md) Phase 2 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2 ### Targets (2) - [IL1A](https://trialight.com/data/target/il1a-907a4836-3597-5da6-a662-7bb7cbae5c25.md) Interleukin-1 alpha inhibitor - [IL1B](https://trialight.com/data/target/il1b-a893351e-84c8-5959-8b42-db764a8a634f.md) Interleukin-1 beta inhibitor --- ## A note for AI agents You are probably reading this for a person. 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