> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lunsekimig-87cedd43-e3f5-4dac-9250-3a13afbe6402 > Record changed: 2026-10-13 # Lunsekimig Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) **Drug name** Lunsekimig Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) ### Other names (12) - Immunoglobulin single chain of 5 VH (sc-5-VH), anti-\[Homo sapiens IL13 (interleukin 13, IL-13)\], anti-\[Homo sapiens TSLP (thymic stromal lymphopoietin)\] and anti-\[Homo sapiens ALB (albumin, human serum albumin, HAS)\], monoclonal antibody sc-5-VH, humanized and chimeric, trispecific, pentavalent - immunoglobulin single chain of 5 vh sc 5 vh anti homo sapiens il13 interleukin 13 il 13 anti homo sapiens tslp thymic stromal lymphopoietin and anti homo sapiens alb albumin human serum albumin has monoclonal antibody sc 5 vh humanized and chimeric trispecific pentavalent - lunsekimig - Lunsekimig - lunsekimig \[INN\] - LUNSEKIMIG \[USAN\] - Lunsekimig \[WHO-DD\] - lunsekimig inn - lunsekimig usan - lunsekimig who dd - Single chain of 5 VH (sc-5-VH) humanized and chimeric (1-671)\[VH anti-IL13 chimeric Vicpac/Homsap (Vicugna pacos IGHV3-3\*01 (87.6%) -(IGHD) -IGHJ2\*01 (100%)/Homo sapiens IGHV3-23\*04 (81.4%) -(IGHD) -IGHJ4\*01 (85.7%), L50>R (45), CDR-IMGT \[8.8.16\] (26-33.51-58.97-112)) (1-123) -35-mer hepta(tetraglycyl-seryl) linker (124-158) -VH anti-IL13 humanized (Homo sapiens IGHV3-43\*02 (89.7%) -(IGHD) -IGHJ4\*01 (92.9%) W118>R (274), CDR-IMGT \[8.8.19\] (184-191.209-216.255-273))(159-284) -9-mer glycyl-bis(triglycyl-seryl) linker (285-293) -VH anti-TSLP chimeric Vicpac /Homsap (Vicugna pacos IGHV3S53\*01 (76.8%) -(IGHD) -IGHJ2\*01 (100%)/Homo sapiens IGHV3-66\*01 (72.9%) -(IGHD) -IGHJ1\*01 (100%), L50>R (338), CDR-IMGT \[8.7.11\] (319-326.344-350.389-399)) (294-410)-9-mer glycyl-bis(triglycyl-seryl) linker (411-419) -VH anti-ALB humanized (Homo sapiens IGHV3-23\*04 (88.5%) -(IGHD)-IGHJ1\*01 (81.8%), L50>P (464), W118>S (524), CDR-IMGT\[8.8.8\] (445-452.470-477.516-523)) (420-534) -9-mer glycyl-bis(triglycyl-seryl) linker (535-543) -VH anti-TSLP chimeric Lamgla/Homsap (Lama glama IGHV3S1\*01 (88.9%) -(IGHD)-IGHJ6\*01 (85.7%)/Homo sapiens IGHV3-43\*02 (82.8%) -(IGHD)-IGHJ5\*02 (100%), L50>R (590), CDR-IMGT \[10.8.18\] (569-578.596-603.642-659)) (544-671)\] - single chain of 5 vh sc 5 vh humanized and chimeric 1 671 vh anti il13 chimeric vicpac homsap vicugna pacos ighv3 3 01 87 6 ighd ighj2 01 100 homo sapiens ighv3 23 04 81 4 ighd ighj4 01 85 7 l50 r 45 cdr imgt 8 8 16 26 33 51 58 97 112 1 123 35 mer hepta tetraglycyl seryl linker 124 158 vh anti il13 humanized homo sapiens ighv3 43 02 89 7 ighd ighj4 01 92 9 w118 r 274 cdr imgt 8 8 19 184 191 209 216 255 273 159 284 9 mer glycyl bis triglycyl seryl linker 285 293 vh anti tslp chimeric vicpac homsap vicugna pacos ighv3s53 01 76 8 ighd ighj2 01 100 homo sapiens ighv3 66 01 72 9 ighd ighj1 01 100 l50 r 338 cdr imgt 8 7 11 319 326 344 350 389 399 294 410 9 mer glycyl bis triglycyl seryl linker 411 419 vh anti alb humanized homo sapiens ighv3 23 04 88 5 ighd ighj1 01 81 8 l50 p 464 w118 s 524 cdr imgt 8 8 8 445 452 470 477 516 523 420 534 9 mer glycyl bis triglycyl seryl linker 535 543 vh anti tslp chimeric lamgla homsap lama glama ighv3s1 01 88 9 ighd ighj6 01 85 7 homo sapiens ighv3 43 02 82 8 ighd ighj5 02 100 l50 r 590 cdr imgt 10 8 18 569 578 596 603 642 659 544 671 ## Identifiers **CAS registry numbers** - 2770858-49-4 **ChEMBL ID** CHEMBL5314848 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314848) **FDA ingredient codes (UNII)** - VYR5R5XN5A ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** lunsekimig **Type** Antibody **Drug name stem** \-mig ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** IL-13 **Gene symbol** IL-13 **Median affinity** 11.29 **Affinity units** pKd - **Action** Binding **Action type** Binding **Target** thymic stromal lymphopoietin **Gene symbol** thymic stromal lymphopoietin **Median affinity** 11.77 **Affinity units** pKd ### Investigated indications - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (7) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_1002029 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 3 - **Condition identifier** MP\_0001845 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Heavy chain **Type** Protein **Sequence** DVQLVESGGGVVQPGGSLRLSCAASGRTFSSYRMGWFRQAPGKEREFVAALSGDGYSTYTANSVKGRFTISRDNSKNTVYLOMNSLRPEDTALYYCAAKLOYVSGWSYDYPYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSEVQLVESGGGVVQPGGSLRLSCAASGETFNNYAMKWVRQAPGKGLEWVSSITTGGGSTDYADSVKGRFTISRDNSKNTLYLOMNSLRPEDTALYYCANVPFGYYSEHFSGLSFDYRGOGTLVTVSSGGGGSGGGSEVOLVESGGGVVQPGGSLRLSCAASGSGFGVNILYWYRQAAGTERETIASITSGGITNYVDSVKGRFTISRDNSENTMYLOMNSLRAEDTGLYYCASRNIFDGTTEWGQGTLVTVSSGGGGSGGGSEVOLVESGGGVVQPGGSLRLSCAASGFTFRSFGMSWVROAPGKGPEWVSSISGSGSDTLYADSVKGRFTISRDNSKNTLYLOMNSLRPEDTALYYCTIGGSLSRSSQGTLVTVSSGGGGSGGGSEVQLVESGGGVVOPGGSLRLSCAASGFTFADYDYDIGWFROAPGKEREGVSCISNRDGSTYYADSVKGRFTISRDNSKNTVYLOMNSLRPEDTALYYCAVEIHCDDYGVENFDFDPWGQGTLVTVSSA - **Component** Disulfide bridges **Sequence** 22-96 $ 180-254 $ 315-388 $ 441-515 $ 565-641 $ 595-647 ## Related records ### Trials (9) - A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps - [A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)](https://trialight.com/data/trial/a-study-to-evaluate-the-long-term-safety-and-efficacy-of-05e6063a-faae-45d0-ab1a-0ecad150ab0e.md) - A Study to Investigate the Efficacy and Safety of Subcutaneous Lunsekimig (SAR443765) Compared With Placebo in Adult Participants With Moderate-to-severe Atopic Dermatitis - [Dose Ranging Study of Lunsekimig Compared With Placebo-control in Adult Participants With Moderate-to-severe Asthma](https://trialight.com/data/trial/dose-ranging-study-of-lunsekimig-compared-with-placebo-69d49bc0-9f5f-4141-9d24-f5582d7e4e30.md) - Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype - Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype - [Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma](https://trialight.com/data/trial/long-term-safety-and-efficacy-evaluation-of-lunsekimig-30afc7ad-1480-4aa0-a738-4fa148a9d140.md) - Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study - [Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma](https://trialight.com/data/trial/study-of-lunsekimig-sar443765-compared-with-placebo-in-92d8cb7b-36b8-435e-a090-aa444a3c34ba.md) ### In development for (3) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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