> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lumicitabine-a67c8b33-7814-47f1-b845-1d18764aed10
> Record changed: 2026-10-13

# Lumicitabine

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

**Drug name**

Lumicitabine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

**Molecular weight**

433.86

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

**Structure (SMILES)**

CC(C)C(=O)OC\[C@@\]1(CCl)O\[C@@H\](n2ccc(N)nc2=O)\[C@H\](F)\[C@@H\]1OC(=O)C(C)C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

### Other names (29)

- als 008176
- als 8176
- ALS-008176
- ALS-008176 (250 mg)
- ALS-008176 (500 mg)
- ALS-008176 (750 mg)
- Als-8176
- Formulation A (ALS-008176)
- Formulation B (ALS-008176)
- Formulation C (ALS-008176)
- Formulation D (ALS-008176)
- Formulation E (ALS-008176)
- Formulation F (ALS-008176)
- Formulation G1 (ALS-008176)
- Formulation G2 (ALS-008176)
- Formulation G3 (ALS-008176)
- Formulation H1 (ALS-008176)
- Formulation H2 (ALS-008176)
- Formulation H3 (ALS-008176)
- lumicitabina
- Lumicitabina
- lumicitabine
- Lumicitabine
- lumicitabine \[INN\]
- LUMICITABINE \[USAN\]

And 4 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1445385-02-3

**ChEMBL ID**

CHEMBL3417258

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

**InChIKey**

MJVKYGMNSQJLIN-KYZVSKTDSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3417258)

**PubChem compound IDs**

- 89658382

**FDA ingredient codes (UNII)**

- BNW5PQ52G1

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-citabine

### Mechanisms of action

- **Mechanism**  
RNA-directed RNA polymerase L inhibitor

**Action type**  
Inhibitor

**Target**  
RNA-directed RNA polymerase L

**Protein identifier**  
P28887

### Open Targets mechanisms

- **Mechanism**  
RNA-directed RNA polymerase L inhibitor

**Action type**  
Inhibitor

**Target**  
RNA-directed RNA polymerase L

### Investigated indications

- **Condition**  
Respiratory Syncytial Virus Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001413

**Subject identifier**  
D018357

### Open Targets indications (3)

- **Condition identifier**  
EFO\_1001413

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001475

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001577

**Highest recorded phase**  
2

### Trial references (9)

- NCT01906164  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01906164)
- NCT02094365  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02094365)
- NCT02202356  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02202356)
- NCT02231671  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02231671)
- NCT02478333  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02478333)
- NCT02673476  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02673476)
- NCT02935673  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02935673)
- NCT03332459  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03332459)
- NCT03333317  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03333317)

## Chemical properties

**Hydrogen bond acceptors**

9

**Hydrogen bond donors**

1

**Polar surface area**

122.74

**Calculated partition coefficient (ALogP)**

1.44

**Calculated partition coefficient (XLogP)**

1.5

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

29

**Molecular formula**

C18H25ClFN3O6

**Monoisotopic mass**

433.1415914

**Natural product**

No

## Evidence counts

**Recorded assays**

25

**Active assays**

6

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

43.5

**Mean**

59.6333

**Minimum**

38.2

**Maximum**

97.2

**Unit**

%

**Assays**

3

**Standard deviation**

32.6414

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (80)

- A Comparative Study of Bioavailability of 3 New Abiraterone Acetate Tablets With Current Commercial Tablet
- A Crossover Study to Assess the Drug-drug Interaction of Acid Reducing Agent(s) on the Pharmacokinetics of a Single Oral Dose of Lumicitabine (JNJ-64041575) in Healthy Adult Participants
- A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult Participants
- A Four Arm Study to Evaluate the Safety and Efficacy of 3 Different Doses of RVX-100 Versus Placebo in Subjects With Irritable Bowel Syndrome Accompanied by Diarrhea (IBS-D)
- A Long-term Follow-up Study to Evaluate the Impact of Lumicitabine on the Incidence of Asthma and/or Wheezing in Infants and Children With a History of Respiratory Syncytial Virus Infection
- A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome
- A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
- A Phase 1, Open-Label Study of the Absorption, Metabolism, Excretion and Absolute Bioavailability of ALS-008176
- A Phase 2a Study to Evaluate ALS-008176 in the Virus Challenge Model
- A Phase 2a Study to Evaluate Orally Administered ALS-008176 in Adults Hospitalized With a Respiratory Syncytial Virus
- A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients
- A Research Study Looking at Different Oral Formulations and the Effect of Food Intake on How the Medicine NNC0487-0111 Behaves in the Body of Participants Living With Overweight or Obesity
- A Safety, Tolerability, and Pharmacokinetics (PK) Study of AGN-223575 in Healthy Subjects
- A Study of ALS-008176 in Infants Hospitalized With RSV
- A Study of OnabotulinumtoxinA X Injection in Adult Participants With Glabellar Lines
- A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants
- A Study to Assess the Amount of Drug Levels in Blood and Safety of AZD5718 Formulations in Healthy Volunteers
- A Study to Evaluate the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) Regimens in Hospitalized Infants and Children Aged 28 Days to 36 Months Infected With Respiratory Syncytial Virus
- A Study to Evaluate the Safety and Immunogenicity of an Adjuvanted RSV Vaccine in Healthy Older Adults
- A Study to Investigate the Relative Bioavailability and Food Effect of an Oral Capsid Inhibitor Tablet Formulation Compared With Other Oral Tablet Formulations in Male and Female Healthy Participants

### In development for (1)

- [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md) Phase 2

---

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