> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lumefantrine-co-artemether-d699f2a3-a171-4901-b60b-0bbdd3509676
> Record changed: 2026-10-13

# Lumefantrine CO-artemether

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297927)

Drug type

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5T2U51A0MW)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297927)

## Names and chemistry

**Drug type**

Small molecule

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5T2U51A0MW)

**Drug name**

Lumefantrine CO-artemether

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297927)

**Structure (SMILES)**

C(CN(CCCC)CCCC)(O)c1cc(Cl)cc/2c1-c3c(cc(cc3)Cl)\\C2=C\\c4ccc(Cl)cc4.CO\[C@@H\]1\[C@H\](C)\[C@@\]2(\[H\])\[C@@\]34OO\[C@@\](C)(O\[C@@\]3(\[H\])O1)CC\[C@@\]4(\[H\])\[C@H\](C)CC2.C(CN(CCCC)CCCC)(O)c1c-2c(/C(=C\\c3ccc(cc3)Cl)/c4c2ccc(c4)Cl)cc(Cl)c1.C(CN(CCCC)CCCC)(O)c1c-2c(/C(=C\\c3ccc(cc3)Cl)/c4c2ccc(c4)Cl)cc(Cl)c1.C(CN(CCCC)CCCC)(O)c1c-2c(/C(=C\\c3ccc(cc3)Cl)/c4c2ccc(c4)Cl)cc(Cl)c1.C(CN(CCCC)CCCC)(O)c1c-2c(/C(=C\\c3ccc(cc3)Cl)/c4c2ccc(c4)Cl)cc(Cl)c1.C(CN(CCCC)CCCC)(O)c1c-2c(/C(=C\\c3ccc(cc3)Cl)/c4c2ccc(c4)Cl)cc(Cl)c1

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5T2U51A0MW)

### Other names (17)

- AL (Coartem)
- al coartem
- coartem
- Coartem
- Coartem® (artemether lumefantrine)
- cpg 56697
- CPG-56697
- fixed 6 1 lumefantrine mixture with artemether
- FIXED 6:1 LUMEFANTRINE MIXTURE WITH ARTEMETHER
- lumefantrine co artemether
- lumefantrine co artemether mi
- Lumefantrine co-artemether
- LUMEFANTRINE CO-ARTEMETHER \[MI\]
- riamet
- Riamet
- Riamet®
- SoC (Coartem)

## Identifiers

**CAS registry numbers**

- 141204-94-6

**ChEMBL ID**

CHEMBL4297927

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297927)

**InChIKey**

VZQXHIJHMCHBNW-UFIXNTOBSA-N

Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5T2U51A0MW)

**PubChem compound IDs**

- 6450800

**FDA ingredient codes (UNII)**

- 5T2U51A0MW

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Investigated indications (2)

- **Condition**  
Malaria

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001068

**Subject identifier**  
D008288
- **Condition**  
Malaria, Falciparum

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007444

**Subject identifier**  
D016778

### Open Targets indications (8)

- **Condition identifier**  
EFO\_0001068

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0007444

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001945

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005136

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005249
- **Condition identifier**  
MONDO\_0005920

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005921
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
3

### Reported adverse events (26)

- **Event**  
asthenia

**Reports**  
16

**Reporting signal score**

11.6607
- **Event**  
autoimmune haemolytic anaemia

**Reports**  
2

**Reporting signal score**

5.57369
- **Event**  
blood bilirubin increased

**Reports**  
5

**Reporting signal score**

7.71995
- **Event**  
cerebral malaria

**Reports**  
2

**Reporting signal score**

15.1758
- **Event**  
chromaturia

**Reports**  
4

**Reporting signal score**

7.72294
- **Event**  
cold agglutinins positive

**Reports**  
1

**Reporting signal score**

5.61027
- **Event**  
coombs negative haemolytic anaemia

**Reports**  
3

**Reporting signal score**

17.1748
- **Event**  
coombs positive haemolytic anaemia

**Reports**  
5

**Reporting signal score**

26.4748
- **Event**  
coombs test negative

**Reports**  
1

**Reporting signal score**

6.99764
- **Event**  
haemolysis

**Reports**  
5

**Reporting signal score**

14.8346
- **Event**  
haemolytic anaemia

**Reports**  
44

**Reporting signal score**

206.537
- **Event**  
haptoglobin decreased

**Reports**  
2

**Reporting signal score**

8.63853
- **Event**  
hepatocellular injury

**Reports**  
6

**Reporting signal score**

11.0422
- **Event**  
hookworm infection

**Reports**  
1

**Reporting signal score**

6.79704
- **Event**  
infection protozoal

**Reports**  
1

**Reporting signal score**

6.79704
- **Event**  
jaundice acholuric

**Reports**  
2

**Reporting signal score**

12.5069
- **Event**  
labia enlarged

**Reports**  
1

**Reporting signal score**

6.10444
- **Event**  
malaria

**Reports**  
3

**Reporting signal score**

14.0335
- **Event**  
malaria antibody test positive

**Reports**  
1

**Reporting signal score**

8.09603
- **Event**  
nematodiasis

**Reports**  
1

**Reporting signal score**

7.80838
- **Event**  
plasmodium falciparum infection

**Reports**  
6

**Reporting signal score**

43.0275
- **Event**  
plasmodium malariae infection

**Reports**  
1

**Reporting signal score**

7.40299
- **Event**  
pyrexia

**Reports**  
18

**Reporting signal score**

12.6954
- **Event**  
skin swelling

**Reports**  
2

**Reporting signal score**

6.47067
- **Event**  
swelling face

**Reports**  
7

**Reporting signal score**

9.76099

And 1 more, listed on the interactive page.

### Trial references (10)

- NCT00484900  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00484900)
- NCT03167242  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03167242)
- NCT04546633  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04546633)
- NCT05750628  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05750628)
- NCT05842954  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05842954)
- NCT02627456  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02627456)
- NCT02942277  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02942277)
- NCT03334747  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03334747)
- NCT03952650  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03952650)
- NCT04675931  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04675931)

## Chemical properties

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

0

## Pharmacologic actions

- Antimalarials  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000962.html)

## Related records

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- A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)
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### In development for (2)

- [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 2
- [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) Phase 3

---

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