> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lumefantrine-5a02c559-879a-4fc5-808f-895181937743 > Record changed: 2026-10-13 # Lumefantrine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) First approval year 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) ## Development status **First approval year** 2009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **Drug name** Lumefantrine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **Molecular weight** 528.95 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **Structure (SMILES)** CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) ### Brand names (2) - lumefantrine component of coartem - Lumefantrine component of coartem ### Other names (23) - artemeter lumefantrine combination therapy - Artemeter-Lumefantrine (combination therapy) - arthemeter lumefantrine - Arthemeter-lumefantrine - benflumelol - Benflumelol - benflumetol - Benflumetol - cpg 56695 - CPG-56695 - d benflumelol - D-BENFLUMELOL - dl benflumelol - Dl-benflumelol - gnf pf 1971 - GNF-PF-1971 - lumefantrina - Lumefantrina - lumefantrine - Lumefantrine - LUMEFANTRINE, (+)- - lumefantrinum - Lumefantrinum ## Identifiers **ChEMBL ID** CHEMBL38827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **InChIKey** DYLGFOYVTXJFJP-MYYYXRDXSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL38827) **PubChem compound IDs** - 6437380 **RxNorm IDs (RxCUI)** - 847728 **FDA ingredient codes (UNII)** - ZUV4B00D9P ### CAS registry numbers (2) - 82186-77-4 - 120583-70-2 ## Regulatory information ### United States **Applicant** NOVARTIS **Approval date** 7 Apr 2009 **Application number** NDA022268 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** lumefantrine **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action - **Mechanism** Ferriprotoporphyrin IX inhibitor **Action type** Inhibitor **Target** Ferriprotoporphyrin IX ### Investigated indications (6) - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Malaria **Highest recorded phase** 4 **Condition identifier** EFO:0001068 **Subject identifier** D008288 - **Condition** Malaria, Falciparum **Highest recorded phase** 3 **Condition identifier** EFO:0007444 **Subject identifier** D016778 - **Condition** Malaria, Vivax **Highest recorded phase** 3 **Condition identifier** EFO:0007445 **Subject identifier** D016780 - **Condition** Schistosomiasis haematobia **Highest recorded phase** 2 **Condition identifier** EFO:0007530 **Subject identifier** D012553 - **Condition** Fever **Highest recorded phase** 3 **Condition identifier** HP:0001945 **Subject identifier** D005334 ### Open Targets indications (10) - **Condition identifier** EFO\_0000764 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001068 - **Condition identifier** EFO\_0007444 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007445 **Highest recorded phase** 3 - **Condition identifier** HP\_0001945 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005136 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005249 - **Condition identifier** MONDO\_0005920 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005921 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Reported adverse events (28) - **Event** asthenia **Reports** 16 **Reporting signal score** 12.1523 - **Event** blood bilirubin increased **Reports** 5 **Reporting signal score** 7.89423 - **Event** blood smear test abnormal **Reports** 1 **Reporting signal score** 5.96703 - **Event** cerebral malaria **Reports** 2 **Reporting signal score** 15.2513 - **Event** chromaturia **Reports** 4 **Reporting signal score** 7.86631 - **Event** congenital hair disorder **Reports** 1 **Reporting signal score** 5.96703 - **Event** conjunctival hyperaemia **Reports** 2 **Reporting signal score** 6.4222 - **Event** coombs negative haemolytic anaemia **Reports** 3 **Reporting signal score** 17.2882 - **Event** coombs positive haemolytic anaemia **Reports** 5 **Reporting signal score** 26.6647 - **Event** coombs test negative **Reports** 1 **Reporting signal score** 7.03527 - **Event** eye discharge **Reports** 2 **Reporting signal score** 5.86802 - **Event** haemolysis **Reports** 5 **Reporting signal score** 15.0213 - **Event** haemolytic anaemia **Reports** 38 **Reporting signal score** 173.71 - **Event** haptoglobin decreased **Reports** 2 **Reporting signal score** 8.71365 - **Event** hepatocellular injury **Reports** 6 **Reporting signal score** 11.2572 - **Event** hookworm infection **Reports** 1 **Reporting signal score** 6.83467 - **Event** infection protozoal **Reports** 1 **Reporting signal score** 6.83467 - **Event** jaundice acholuric **Reports** 2 **Reporting signal score** 12.5823 - **Event** labia enlarged **Reports** 1 **Reporting signal score** 6.5544 - **Event** malaria **Reports** 2 **Reporting signal score** 8.61798 - **Event** malaria antibody test positive **Reports** 1 **Reporting signal score** 8.13366 - **Event** nematodiasis **Reports** 1 **Reporting signal score** 7.84602 - **Event** plasmodium falciparum infection **Reports** 6 **Reporting signal score** 43.2563 - **Event** pyrexia **Reports** 17 **Reporting signal score** 11.7206 - **Event** skin swelling **Reports** 2 **Reporting signal score** 6.24236 And 3 more, listed on the interactive page. ### Trial references (86) - NCT00118794 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00118794) - NCT00123552 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00123552) - NCT00140361 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00140361) - NCT00297882 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00297882) - NCT00336375 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00336375) - NCT00386750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00386750) - NCT00386763 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00386763) - NCT00393679 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00393679) - NCT00406146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00406146) - NCT00444106 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00444106) - NCT00451139 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00451139) - NCT00452907 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00452907) - NCT00454961 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00454961) - NCT00495508 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00495508) - NCT00540202 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00540202) - NCT00541385 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00541385) - NCT00694694 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00694694) - NCT00808951 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00808951) - NCT01038063 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01038063) - NCT01075945 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01075945) - NCT01082731 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01082731) - NCT01150344 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01150344) - NCT01152931 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01152931) - NCT01374581 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01374581) - NCT01445938 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01445938) And 61 more, listed on the interactive page. ## Dosing **Dose** 4 tablets for adults 35 kg and above; 1-4 tablets based on bodyweight for children **Route** Oral **How often** 3 days (initial dose, after 8 hours, then twice daily for 2 days) ### Conditions of use (2) - Crush and mix with water if necessary - Take with food ## Chemical properties **Hydrogen bond acceptors** 2 **Hydrogen bond donors** 1 **Polar surface area** 23.47 **Calculated partition coefficient (ALogP)** 9.15 **Calculated partition coefficient (XLogP)** 8.7 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 10 **Heavy atoms** 35 **Molecular formula** C30H32Cl3NO **Monoisotopic mass** 527.154948 **Natural product** Yes ## Evidence counts **Recorded assays** 873 **Active assays** 206 ### Active assay types (3) - Confirmatory - Other - Summary ## Pharmacologic actions - Antimalarials Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000962.html) ## Biological measurements ### Observed measurements #### Cardiac potassium channel inhibition **Median** 380 **Mean** 3,473.06 **Minimum** 377 **Maximum** 8,128.31 **Unit** nM **Assays** 5 **Standard deviation** 4,236.73 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - IC50 ## Related records ### Trials (128) - A Combination Product of Sumatriptan and Naproxen Sodium Versus Single-entity Oral Triptans: An Analysis of Real World Data - A Combination Therapy Including Anti-PD-1 Immunotherapy in MSS Rectal Cancer With Resectable Distal Metastasis - A Combination Therapy Including Anti-PD-1 Immunotherapy in Rectal Cancer With Refractory Distal Metastasis - A Preliminary Study on the Efficacy of Danggui Shaoyao San and Cuscuta Chinensis in Patients with Primary Dysmenorrhea - A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy - A Registry-based Randomized Controlled Trial in Type 2 Diabetes With Cardiovascular Risk Factors (REMATCH) - A Single Dose Phase I Exploratory Study in Healthy Volunteers With GSK2894512 Cream - A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma - A Study of JS009 Monotherapy and JS009 as a Triple Combination Therapy in Patients With Advanced Malignancies - A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Who Were Insufficiently Responsive to Monotherapy - A Study of PY314 in Subjects With Advanced Solid Tumors - A Study of RC148 As a Single Agent and Combination Therapy in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors - A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma - A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003) - A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate - A Therapeutic Protocol in Previous Failed ART Patients With High Total NK Cells - Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure - ACT MALI: Treatment of Malaria Based on Combination Therapies - Adebrelimab Plus Full-course Neoadjuvant Therapy for Resectable Locally Advanced ESCC (Phase 2) - Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial ### Approved for (1) - [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) ### In development for (4) - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) Phase 3 - Plasmodium vivax malaria Phase 3 - Urinary schistosomiasis Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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