> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lucorafusp-alfa-666dd8b0-3456-4f44-9998-0b2039d37ff9
> Record changed: 2026-11-04
# Lucorafusp alfa
Highest phase reached
Phase 2
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
Drug type
Protein
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
## Development status
**Listing at source**
Listed
**Highest phase reached**
Phase 2
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
## Names and chemistry
**Drug type**
Protein
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
**Drug name**
Lucorafusp alfa
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
### Other names (15)
- ak 130
- AK-130
- ak130
- Ak130
- AK130
- gamma 4 heavy chain (1-447) \[VH (Homo sapiens IGHV4-30-4\*01 -(IGHD) -IGHJ4\*01, CDR-Kabat \[6.16.12\] (31-36.51-66.99-110)) (1-121) -Homo sapiens IGHG4\*01 (CH1 (122-219), hinge S229>P (220-231), CH2 F235>A, L236>A (232-341), CH3 (342-446), CHS K448>del (447)) (122-447)\] fused via a (G4S)4 peptide linker (448-467) to human TGF-beta receptor type-2 (TGFR-2, TGFBR2, transforming growth factor-beta receptor type II, TGFβ type II receptor, TGFβRII) extracellular domain fragment 23-159, (1-137 of the mature protein) \[T23>G468, S31>T476\]-variant (468-604 in the current sequence), (135-214')-disulfide with kappa light chain (1'-214') \[V-KAPPA (Homo sapiens IGKV1-39\*01 -IGKJ1\*01, CDR-Kabat \[11.7.9\] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (108'-214')\]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
- gamma 4 heavy chain 1 447 vh homo sapiens ighv4 30 4 01 ighd ighj4 01 cdr kabat 6 16 12 31 36 51 66 99 110 1 121 homo sapiens ighg4 01 ch1 122 219 hinge s sup 229 sup p 220 231 ch2 f sup 235 sup a l sup 236 sup a 232 341 ch3 342 446 chs k sup 448 sup del 447 122 447 fused via a g4s 4 peptide linker 448 467 to human tgf beta receptor type 2 tgfr 2 tgfbr2 transforming growth factor beta receptor type ii tgfβ type ii receptor tgfβrii extracellular domain fragment 23 159 1 137 of the mature protein t sup 23 sup g sup 468 sup s sup 31 sup t sup 476 sup variant 468 604 in the current sequence 135 214 disulfide with kappa light chain 1 214 v kappa homo sapiens igkv1 39 01 igkj1 01 cdr kabat 11 7 9 24 34 50 56 89 97 1 107 homo sapiens igkc 01 108 214 dimer 227 227 230 230 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- humanized immunoglobulin g4 kappa anti human tigit t cell immunoreceptor with ig domain and itim v set ig member 9 vsig9 v set and transmembrane member 3 vstm3 fused at the c terminus of the heavy chain via a g4s 4 peptide linker to a fragment of the mature extracellular domain of human tgf beta receptor type 2 glycoform alfa
- humanized immunoglobulin G4-kappa, anti-\[human TIGIT (T cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)\] fused at the C-terminus of the heavy chain, via a (G4S)4 peptide linker, to a fragment of the mature extracellular domain of human TGF-beta receptor type-2, glycoform alfa
- Immunoglobulin G4 \[229-proline,235-alanine,236-alanine,476-threonine,de-468-lysine\], anti-(human receptor TIGIT) (human-Mus musculus monoclonal AK130 γ4-chain) fusion protein with peptide linker ((GGGGS)4G) fusion protein with 2-137-transforming growth factor β receptor 2 \[9-threonine\] (human), disulfide with human-Mus musculus monoclonal AK130 κ-chain, dimer
- immunoglobulin g4 229 proline 235 alanine 236 alanine 476 threonine de 468 lysine anti human receptor tigit human mus musculus monoclonal ak130 γ4 chain fusion protein with peptide linker ggggs 4g fusion protein with 2 137 transforming growth factor β receptor 2 9 threonine human disulfide with human mus musculus monoclonal ak130 κ chain dimer
- lucorafusp alfa
- Lucorafusp alfa
- lucorafusp alfa \[INN\]
- lucorafusp alfa inn
## Identifiers
**CAS registry numbers**
- 2769742-99-4
**ChEMBL ID**
CHEMBL6068134
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068134)
**FDA ingredient codes (UNII)**
- M55KSH2AGH
## Regulatory information
### Other regulatory facts
**First in class**
No
**Orphan designation**
No
## Pharmacology
### Drug classification
**Drug name stem**
\-fusp
### Investigated indications
- **Condition**
Neoplasms
**Highest recorded phase**
1
**Condition identifier**
MONDO:0004992
**Subject identifier**
D009369
### Open Targets indications (5)
- **Condition identifier**
MONDO\_0003060
**Highest recorded phase**
1
- **Condition identifier**
MONDO\_0004992
**Highest recorded phase**
1
- **Condition identifier**
MONDO\_0007256
**Highest recorded phase**
1
- **Condition identifier**
MONDO\_0009831
**Highest recorded phase**
2
- **Condition identifier**
MONDO\_0021040
**Highest recorded phase**
2
### Trial references
- NCT05653284
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05653284)
## Chemical properties
**Prodrug**
No
**Chirality**
Single enantiomer
**Inorganic**
No
**Natural product**
No
## Related records
### Trials (4)
- [A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC)](https://trialight.com/data/trial/a-study-of-ak112-in-patients-with-advanced-hepatocellular-b2d889dd-53f2-49cd-90b6-05e07b05740d.md)
- A Study of AK130 in Combination With AK112 for the Treatment of Advanced Biliary Tract Cancer
- A Study of AK130 in Combination With AK112 for the Treatment of Advanced Pancreatic Cancer
- A Study of AK130 in Patients With Advanced Malignant Tumors
### In development for (5)
- [Biliary tract cancer](https://trialight.com/data/condition/biliary-tract-cancer-6b9535c9-ccaa-5b47-8c46-0d05d39d7c62.md) Phase 1
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 1
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 2
- [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 2
---
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