> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lotiglipron-f5e44cf3-bbf2-4ac8-bb28-452192f1d0d4
> Record changed: 2026-10-13

# Lotiglipron

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

**Drug name**

Lotiglipron

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

**Molecular weight**

575.07

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

**Structure (SMILES)**

C\[C@\]1(c2ccc(Cl)cn2)Oc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C\[C@@H\]4CCO4)CC3)c2O1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

### Other names (13)

- Formulation B (PF-07081532 80 mg)
- formulation b pf 07081532 80 mg
- lotiglipron
- Lotiglipron
- lotiglipron \[INN\]
- LOTIGLIPRON \[USAN\]
- Lotiglipron \[WHO-DD\]
- lotiglipron inn
- lotiglipron usan
- lotiglipron who dd
- pf 07081532
- Pf-07081532
- PF-07081532

## Identifiers

**CAS registry numbers**

- 2401892-75-7

**ChEMBL ID**

CHEMBL5314631

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

**InChIKey**

SVPYZAJTWFQTSM-UGDMGKLASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314631)

**PubChem compound IDs**

- 146609022

**FDA ingredient codes (UNII)**

- YI10W1K93A

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

lotiglipron

**Type**

Synthetic organic

**Drug name stem**

\-glipron

### Mechanisms of action

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**

9.02

**Affinity units**  
pEC50

### Investigated indications (3)

- **Condition**  
Obesity

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
2

### Trial references (5)

- NCT04305587  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04305587)
- NCT05158244  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05158244)
- NCT05478603  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05478603)
- NCT05671653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05671653)
- NCT05677867  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05677867)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

98.94

**Calculated partition coefficient (ALogP)**

5.6

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

7

**Heavy atoms**

41

**Molecular formula**

C31H31ClN4O5

**Monoisotopic mass**

574.1982978

**Natural product**

No

## Evidence counts

**Recorded assays**

3

**Active assays**

3

### Active assay types

- Confirmatory

## Related records

### Trials (11)

- A Clinical Trial of the Study Medicine (PF-07081532) in People With Diabetes and Kidney Dysfunction
- A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult Participants
- A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclosporine on PF-07081532 Pharmacokinetics in Overweight or Obese Adults
- A Study to Compare Two Different Forms of PF-07081532 in Adults Who Are Overweight or Obese
- A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range
- A Study to Understand How the Study Medicine (PF-07081532) is Processed and Eliminated in Healthy Men
- A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction
- Multiple Escalating Oral Doses Study of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
- Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
- Study of Single Ascending Doses of PF-07081532 in Healthy Adult Participants
- [Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity](https://trialight.com/data/trial/trial-to-learn-about-the-study-medicine-pf-07081532-and-a633f8ed-7066-49d8-a831-09a52f7ff584.md)

### In development for (3)

- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 1
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1

---

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