> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lorundrostat-c0863b53-0f6c-4044-b54f-78bf207c9c16
> Record changed: 2026-10-13

# Lorundrostat

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

**Drug name**

Lorundrostat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

**Molecular weight**

451.58

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

**Structure (SMILES)**

CC(=O)N\[C@H\]1CC\[C@H\](NC(=O)CN2CCN(c3nncc(-c4ccc(C)cc4)n3)CC2)CC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

### Other names (20)

- lorundrostat
- Lorundrostat
- lorundrostat \[INN\]
- LORUNDROSTAT \[USAN\]
- Lorundrostat \[WHO-DD\]
- lorundrostat inn
- lorundrostat usan
- lorundrostat who dd
- mls 101
- mls 101 free base
- MLS-101
- MLS-101 FREE BASE
- mls101 free base
- MLS101 FREE BASE
- mt 4129
- mt 4129 free base
- MT-4129
- MT-4129 FREE BASE
- mt4129 free base
- MT4129 FREE BASE

## Identifiers

**CAS registry numbers**

- 1820940-17-7

**ChEMBL ID**

CHEMBL5095105

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

**InChIKey**

YHGVDZULVMINCJ-MEMLXQNLSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095105)

**FDA ingredient codes (UNII)**

- KA8W5LDS6Z

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

lorundrostat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
CYP11B1

**Gene symbol**  
CYP11B1

**Protein identifier**  
P15538

**Median affinity**

6.32

**Affinity units**  
pKi
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
CYP11B2

**Gene symbol**  
CYP11B2

**Protein identifier**  
P19099

**Median affinity**

8.9

**Affinity units**  
pKi

### Investigated indications (3)

- **Condition**  
Hypertension

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Heart Failure

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333
- **Condition**  
Renal Insufficiency, Chronic

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003884

**Subject identifier**  
D051436

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003144
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004285

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005252
- **Condition identifier**  
MONDO\_0005300

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007147

**Highest recorded phase**  
2

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

2

**Polar surface area**

103.35

**Calculated partition coefficient (ALogP)**

1.53

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

33

**Molecular formula**

C24H33N7O2

**Natural product**

No

## Related records

### Trials (5)

- [A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen](https://trialight.com/data/trial/a-pivotal-study-to-evaluate-the-efficacy-of-lorundrostat-in-3e37ddcd-b83d-445c-9ce0-2e7d28292cf5.md)
- A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension
- Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria
- [Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension](https://trialight.com/data/trial/efficacy-and-safety-of-lorundrostat-in-subjects-with-da242d34-f2d5-43ce-ae57-e27f7924b996.md)
- [Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension](https://trialight.com/data/trial/open-label-extension-ole-study-to-assess-safety-efficacy-and-2b291777-4813-4ae7-91bb-a3e8b1329e69.md)

### In development for (3)

- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 1
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 1
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 1

---

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