> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/londamocitinib-2c34f105-e2dc-4a2a-b127-59215d7c0387
> Record changed: 2026-10-13

# Londamocitinib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

**Drug name**

Londamocitinib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

**Molecular weight**

599.66

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

**Structure (SMILES)**

COC\[C@H\](C(=O)Nc1cccc2c(-c3nc(Nc4cccc(S(C)(=O)=O)c4F)ncc3F)c\[nH\]c12)N1CCN(C)CC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

### Other names (15)

- (R)-N-(3-(5-Fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide
- azd 4604
- AZD-4604
- azd4604
- Azd4604
- AZD4604
- londamocitinib
- Londamocitinib
- londamocitinib \[INN\]
- LONDAMOCITINIB \[USAN\]
- Londamocitinib \[WHO-DD\]
- londamocitinib inn
- londamocitinib usan
- londamocitinib who dd
- r n 3 5 fluoro 2 2 fluoro 3 methylsulfonyl phenyl amino pyrimidin 4 yl 1h indol 7 yl 3 methoxy 2 4 methylpiperazin 1 yl propanamide

## Identifiers

**CAS registry numbers**

- 2241039-81-4

**ChEMBL ID**

CHEMBL4447181

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

**InChIKey**

JNUZADQZHYFJGW-JOCHJYFZSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4447181)

**PubChem compound IDs**

- 135240395

**FDA ingredient codes (UNII)**

- JAC34RRR7S

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

londamocitinib

**Type**

Synthetic organic

**Drug name stem**

\-tinib

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Janus kinase 2

**Gene symbol**  
JAK2

**Protein identifier**  
O60674

**Median affinity**

5.91

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Janus kinase 1

**Gene symbol**  
JAK1

**Protein identifier**  
P23458

**Median affinity**

8.52

**Affinity units**  
pIC50

### Open Targets indications

- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
2

## Chemical properties

**Hydrogen bond acceptors**

9

**Hydrogen bond donors**

3

**Polar surface area**

132.55

**Calculated partition coefficient (ALogP)**

3.25

**Calculated partition coefficient (XLogP)**

2.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

9

**Heavy atoms**

42

**Molecular formula**

C28H31F2N7O4S

**Monoisotopic mass**

599.21262999

**Natural product**

No

## Evidence counts

**Recorded assays**

56

**Active assays**

14

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (6)

- A Clinical Trial in Healthy Volunteers and Patients With Mild Asthma to Investigate a New Medicine (AZD4604) for the Treatment of Asthma
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled AZD4604 in Healthy Japanese and Chinese Participants.
- An ADME Study of \[14C\]AZD4604 and the Absolute Bioavailability of AZD4604
- [Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA](https://trialight.com/data/trial/phase-2a-study-to-assess-the-efficacy-and-safety-of-azd4604-2c903910-2a97-4a16-bcac-d212813fa119.md)
- Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
- Study to Evaluate the Pharmacokinetics and Pharmacodynamics of AZD4604 Given Via the Turbuhaler® Device in Adults With Mild Asthma.

### In development for (1)

- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2

---

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