Livmoniplimab
Highest phase reached
Phase 2
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Antibody
- Drug name
- Livmoniplimab
- abbv 151
- Abbv 151
- ABBV-151
- abbv151
- ABBV151
- argx 115
- ARGX-115
- Immunoglobulin G4 [234-proline], anti-(human protein GARP-transforming growth factor β1 complex) (human monoclonal ABBV-151 γ4-chain), disulfide with human monoclonal ABBV-151 κ-chain, dimer
- immunoglobulin g4 234 proline anti human protein garp transforming growth factor β1 complex human monoclonal abbv 151 γ4 chain disulfide with human monoclonal abbv 151 κ chain dimer
- immunoglobulin g4 kappa anti homo sapiens lrrc32 leucine rich repeat containing 32 transforming growth factor beta activator lrrc32 glycoprotein a repetitions predominant garp homo sapiens tgfb1 transforming growth factor beta1 tgf beta complex chimeric and humanized monoclonal antibody gamma4 heavy chain chimeric 1 452 vh vicpac homsap vicugna pacos ighv1 1 01 87 8 ighd ighj3 01 100 homo sapiens ighv1 46 01 85 7 ighd ighj4 01 85 7 cdr imgt 8 8 19 26 33 51 58 97 115 1 126 homo sapiens ighg4 01 g4v5 h p10 ch1 127 224 hinge 1 12 s10 p 234 225 236 ch2 237 346 ch3 347 451 chs k2 del 452 127 452 140 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 39 01 85 3 igkj1 01 100 cdrimgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 232 232 235 235 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa
- Immunoglobulin G4-kappa, anti-[Homo sapiens LRRC32 (leucine rich repeat containing 32, transforming growth factor beta activator LRRC32, glycoprotein A repetitions predominant, GARP) / Homo sapiens TGFB1 (transforming growth factor beta1, TGF beta) complex], chimeric and humanized monoclonal antibody; gamma4 heavy chain chimeric (1-452) [VH Vicpac/Homsap (Vicugna pacos IGHV1-1*01 (87.8%) - (IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (85.7%), CDR-IMGT [8.8.19] (26-33.51-58.97-115)) (1-126)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (127-224), hinge 1-12 S10>P (234) (225-236), CH2 (237-346), CH3 (347-451), CHS K2>del (452)) (127-452)], (140-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (85.3%) -IGKJ1*01 (100%), CDRIMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
- livmoniplimab
- Livmoniplimab
- livmoniplimab [INN]
- LIVMONIPLIMAB [USAN]
- Livmoniplimab [WHO-DD]
- livmoniplimab inn
- livmoniplimab usan
- livmoniplimab who dd
- pr 1762844
- PR-1762844
- CAS registry numbers
- 2412004-88-5
- ChEMBL ID
- CHEMBL5314989
- FDA ingredient codes (UNII)
- 42SH7JCD82
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- livmoniplimab
- Type
- Antibody
- Drug name stem
- -mab
Mechanisms of action
- Action
- Binding
- Action type
- Binding
- Target
- leucine rich repeat containing 32
- Gene symbol
- LRRC32
- Protein identifier
- Q14392
- Median affinity
- 9.12
- Affinity units
- pKd
- Primary target
- Yes
- Condition
- Carcinoma, Hepatocellular
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000182
- Subject identifier
- D006528
- Condition
- Neoplasms
- Highest recorded phase
- 1
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition
- Carcinoma, Non-Small-Cell Lung
- Highest recorded phase
- 2
- Condition identifier
- EFO:0003060
- Subject identifier
- D002289
- Condition
- Neoplasms
- Highest recorded phase
- 1
- Condition identifier
- MONDO:0004992
- Subject identifier
- D009369
- Condition identifier
- EFO_0000616
- Condition identifier
- EFO_0003060
- Condition identifier
- MONDO_0004992
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0005070
- Condition identifier
- MONDO_0005233
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0007256
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0040679
- Highest recorded phase
- 2
- NCT03821935
- NCT05822752
- NCT06109272
- NCT06236438
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QVQLVQPGAEVRKPGASVKVSCKASGYRFTSYYIDWVRQAPGQGLEWMGRIDPEDAGTKYAQKFQGRVTMTADTSTSTVYVELSSLRSEDTAVYYCARYEWETVVVGDLMYEYEYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG
- Component
- Glycosylation sites (N)
- Sequence
- 303 $ 303''
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 140-214' $ 140''-214''' $ 153-209 $ 153''-209'' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431''
- Component
- Light chain
- Type
- Protein
- Sequence
- DIQMTQSPSSLSASVGDRVTITCQASQSISSYLAWYQQKPGQAPKILIYGASRLKTGVPSRFSGSGSGTSFTLTISSLEPEDAATYYCQQYASVPVTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Related records
Trials (6)
- A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in Combination With Budigalimab Moves Through the Bodies of Adult Chinese Participants With Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC)
- A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
- Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors
- Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)
- Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)
- Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
In development for (4)
- Cancer Phase 1
- Hepatocellular carcinoma Phase 2
- Neoplasm Phase 1
- Non-small cell lung carcinoma Phase 2