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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/litifilimab-7b0edbb2-543a-4a80-9535-9455f1432e2a > Record changed: 2026-10-13 # Litifilimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) **Drug name** Litifilimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) ### Other names (21) - 24f4a - 24F4A - anti bdca2 - anti-BDCA2 - biib 059 - Biib 059 - BIIB-059 - biib059 - Biib059 - BIIB059 - BIIB059 (litifilimab) - immunoglobulin g1 anti human blood dendritic cell antigen 2 human mus musculus monoclonal biib059 gamma 1 chain disulfide with human mus musculus monoclonal biib059 kappa chain dimer - IMMUNOGLOBULIN G1, ANTI-(HUMAN BLOOD DENDRITIC CELL ANTIGEN 2) (HUMAN-MUS MUSCULUS MONOCLONAL BIIB059 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL BIIB059 .KAPPA.-CHAIN, DIMER - litifilimab - Litifilimab - litifilimab \[INN\] - LITIFILIMAB \[USAN\] - Litifilimab \[WHO-DD\] - litifilimab inn - litifilimab usan - litifilimab who dd ## Identifiers **CAS registry numbers** - 2407378-48-5 **ChEMBL ID** CHEMBL3833308 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3833308) **FDA ingredient codes (UNII)** - V27E9V3K7G ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** litifilimab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** C-type lectin domain family 4 member C **Gene symbol** CLEC4C **Protein identifier** Q8WTT0 - **Mechanism** C-type lectin domain family 4 member C inhibitor **Action type** Inhibitor **Target** C-type lectin domain family 4 member C **Protein identifier** Q8WTT0 ### Open Targets mechanisms - **Mechanism** C-type lectin domain family 4 member C inhibitor **Action type** Inhibitor **Target** C-type lectin domain family 4 member C ### Investigated indications (3) - **Condition** Lupus Erythematosus, Cutaneous **Highest recorded phase** 3 **Condition identifier** EFO:0003834 **Subject identifier** D008178 - **Condition** Autoimmune Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0005809 **Subject identifier** D001327 - **Condition** Lupus Erythematosus, Systemic **Highest recorded phase** 3 **Condition identifier** MONDO:0007915 **Subject identifier** D008180 ### Open Targets indications (6) - **Condition identifier** EFO\_0003834 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005809 - **Condition identifier** MONDO\_0005282 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0007179 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0015574 **Highest recorded phase** 2 ### Trial references (5) - NCT02106897 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02106897) - NCT02847598 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02847598) - NCT04895241 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04895241) - NCT04961567 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04961567) - NCT06044337 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06044337) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'''' - **Component** Heavy chain **Type** Protein **Sequence** DVQLVESGGGLVKPGGSLRLSCAASGFTFSTYTMSWVRQAPGKGLEWVATISPGDSFGYYYPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCTRDIYYNYGAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Light chain **Type** Protein **Sequence** DIQLTQSPSSLSASVGDRVTITCKASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASTLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANEDPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'' - **Component** Disulfide bridges **Sequence** 22-97 $ 22''-97'' $ 23'-92' $ 23'''-92''' $ 138'-198' $ 138'''-198''' $ 149-205 $ 149''-205'' $ 225-218' $ 225''-218''' $ 231-231'' $ 234-234'' $ 266-326 $ 266''-326'' $ 372-430 $ 372''-430'' ## Related records ### Trials (9) - A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - [A Study to Find Out How Litifilimab is Processed in the Body in Healthy Participants When Given Under the Skin in 3 Different Ways](https://trialight.com/data/trial/a-study-to-find-out-how-litifilimab-is-processed-in-the-body-8cf31b4c-cb0c-4bdc-af2c-a813de5b2e3e.md) - A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - An Extension Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus - Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy Japanese Subjects. - Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 (Litifilimab) in Healthy Volunteers and Participants With Systemic Lupus Erythematosus - Study to Evaluate BIIB059 (Litifilimab) in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) ### In development for (3) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) Phase 2 - [Cutaneous lupus erythematosus](https://trialight.com/data/condition/cutaneous-lupus-erythematosus-d8209c16-c236-521f-8fd1-cd89b5810e23.md) Phase 3 - [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 3 ### Targets (1) - [CLEC4C](https://trialight.com/data/target/clec4c-3a0e0bbf-e22d-5b05-8801-ee683a6db606.md) C-type lectin domain family 4 member C inhibitor --- ## A note for AI agents You are probably reading this for a person. 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