> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/linaprazan-glurate-404f09dc-48f6-4a46-a6c8-1e427bbbdcdf > Record changed: 2026-11-04 # Linaprazan glurate Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) **Drug name** Linaprazan glurate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) **Molecular weight** 480.57 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) **Structure (SMILES)** Cc1cccc(C)c1CNc1cc(C(=O)NCCOC(=O)CCCC(=O)O)cn2c(C)c(C)nc12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) ### Other names (36) - 14c x842 - glurate de linaprazan - Glurate de linaprazan - glurato de linaprazan - Glurato de linaprazan - linaprazan glurate - Linaprazan glurate - linaprazan glurate \[INN\] - LINAPRAZAN GLURATE \[USAN\] - Linaprazan glurate \[WHO-DD\] - linaprazan glurate 25 mg bid - linaprazan glurate 25 mg BID - linaprazan glurate 25 mg qd - linaprazan glurate 25 mg QD - linaprazan glurate 50 mg bid - linaprazan glurate 50 mg BID - linaprazan glurate 50 mg qd - linaprazan glurate 50 mg QD - linaprazan glurate 75 mg bid - linaprazan glurate 75 mg BID - linaprazan glurate 75 mg qd - linaprazan glurate 75 mg QD - linaprazan glurate capsules - Linaprazan Glurate Capsules - linaprazan glurate inn And 11 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1228559-81-6 **ChEMBL ID** CHEMBL5095187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) **InChIKey** GPHPBXRKAJSSIC-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095187) **PubChem compound IDs** - 46208366 **FDA ingredient codes (UNII)** - 3VG4D399DT ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-prazan ### Investigated indications - **Condition** Gastroesophageal Reflux **Highest recorded phase** 1 **Condition identifier** EFO:0003948 **Subject identifier** D005764 ### Open Targets indications (3) - **Condition identifier** EFO\_0003948 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006781 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007186 **Highest recorded phase** 3 ### Trial references (2) - NCT05469854 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05469854) - NCT05742984 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05742984) ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 3 **Polar surface area** 122.03 **Calculated partition coefficient (ALogP)** 3.71 **Calculated partition coefficient (XLogP)** 3.7 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 11 **Heavy atoms** 35 **Molecular formula** C26H32N4O5 **Monoisotopic mass** 480.23727013 **Natural product** No ## Related records ### Trials (13) - A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Maintenance of Healing in Participants With Healed Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD) - A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD) - A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole - [A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate](https://trialight.com/data/trial/a-study-to-investigate-the-pharmacokinetics-and-ecg-effects-b40a6d1c-f593-455c-9ff9-60db6950d692.md) - Drug Interaction Study on Linaprazan Glurate Capsules - Effect of Clarithromycin on PK of Linaprazan, Linaprazan on PK of Clarithromycin and Linaprazan on PK of Midazolam - Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects - Mass Balance Study of \[14C\]X842 in Healthy Adult Male Subjects - Relative Bioavailability of Linaprazan for the Test Formulation vs. Reference Formulation - Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study - Single-dose and Multiple-dose X842 Phase 1 Study - Study to Evaluate the Safety and Efficacy of X842 in Patients With Reflux Esophagitis - The Phase III Clinical Trial of X842 Capsules for Reflux Esophagitis ### In development for (2) - [Gastroesophageal reflux disease](https://trialight.com/data/condition/gastroesophageal-reflux-disease-98b37c15-1154-58ee-9085-aa95708c220a.md) Phase 1 - [Helicobacter pylori infectious disease](https://trialight.com/data/condition/helicobacter-pylori-infectious-disease-ff5903ca-758b-5979-a633-075499e2938b.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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