> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lifitegrast-sodium-b020c8d8-25e0-4450-b699-9d4068a9d60a
> Record changed: 2026-10-13

# Lifitegrast sodium

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

## Development status

**Listing at source**

Listed

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

**Drug name**

Lifitegrast sodium

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

**Molecular weight**

637.47

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

**Structure (SMILES)**

CS(=O)(=O)c1cccc(C\[C@H\](NC(=O)c2c(Cl)cc3c(c2Cl)CCN(C(=O)c2ccc4ccoc4c2)C3)C(=O)\[O-\])c1.\[Na+\]

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

### Other names (13)

- l phenylalanine n 2 6 benzofuranylcarbonyl 5 7 dichloro 1 2 3 4 tetrahydro 6 isoquinolinyl carbonyl 3 methylsulfonyl sodium salt 1 1
- L-PHENYLALANINE, N-((2-(6-BENZOFURANYLCARBONYL)-5,7-DICHLORO-1,2,3,4-TETRAHYDRO-6-ISOQUINOLINYL)CARBONYL)-3-(METHYLSULFONYL)-, SODIUM SALT (1:1)
- lifitegrast sodium
- Lifitegrast sodium
- LIFITEGRAST SODIUM \[USAN\]
- Lifitegrast sodium \[WHO-DD\]
- lifitegrast sodium usan
- lifitegrast sodium who dd
- sar 1118 023
- SAR 1118-023
- SAR-1118-023
- Sodium (2S)-2-({\[2-(benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-yl\]carbonyl}amino)-3-\[3-(methylsulfonyl)phenyl\]propanoate
- sodium 2s 2 2 benzofuran 6 ylcarbonyl 5 7 dichloro 1 2 3 4 tetrahydroisoquinolin 6 yl carbonyl amino 3 3 methylsulfonyl phenyl propanoate

## Identifiers

**CAS registry numbers**

- 1119276-80-0

**ChEMBL ID**

CHEMBL2048409

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

**InChIKey**

BPWOKOSRORLLIN-BQAIUKQQSA-M

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2048409)

**PubChem compound IDs**

- 56963348

**FDA ingredient codes (UNII)**

- QG18FLP1KP

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-ast

### Open Targets mechanisms

- **Mechanism**  
Integrin alpha-L/beta-2 (LFA-1) antagonist

**Action type**  
Antagonist

**Target**  
Integrin alpha-L/beta-2 (LFA-1)

### Open Targets indications (5)

- **Condition identifier**  
HP\_0001097

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003799

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005328

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005642

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006733

**Highest recorded phase**  
4

### Reported adverse events (102)

- **Event**  
abdominal pain

**Reports**  
4

**Reporting signal score**

26.5742
- **Event**  
abnormal sensation in eye

**Reports**  
18

**Reporting signal score**

48.6528
- **Event**  
anaemia

**Reports**  
1

**Reporting signal score**

35.9026
- **Event**  
arthralgia

**Reports**  
2

**Reporting signal score**

46.0898
- **Event**  
asthenia

**Reports**  
4

**Reporting signal score**

38.8517
- **Event**  
asthenopia

**Reports**  
15

**Reporting signal score**

38.5092
- **Event**  
back pain

**Reports**  
4

**Reporting signal score**

18.0137
- **Event**  
burning sensation

**Reports**  
31

**Reporting signal score**

18.3043
- **Event**  
constipation

**Reports**  
4

**Reporting signal score**

17.0004
- **Event**  
corneal abrasion

**Reports**  
6

**Reporting signal score**

14.969
- **Event**  
corneal disorder

**Reports**  
9

**Reporting signal score**

19.1738
- **Event**  
decreased appetite

**Reports**  
4

**Reporting signal score**

16.3723
- **Event**  
depression

**Reports**  
1

**Reporting signal score**

25.1915
- **Event**  
diarrhoea

**Reports**  
10

**Reporting signal score**

63.9608
- **Event**  
drug interaction

**Reports**  
3

**Reporting signal score**

26.3372
- **Event**  
dry eye

**Reports**  
165

**Reporting signal score**

449.044
- **Event**  
dysgeusia

**Reports**  
315

**Reporting signal score**

834.743
- **Event**  
dyspnoea

**Reports**  
35

**Reporting signal score**

18.5158
- **Event**  
erythema of eyelid

**Reports**  
12

**Reporting signal score**

24.2809
- **Event**  
eye complication associated with device

**Reports**  
4

**Reporting signal score**

15.7243
- **Event**  
eye discharge

**Reports**  
81

**Reporting signal score**

274.554
- **Event**  
eye disorder

**Reports**  
66

**Reporting signal score**

134.128
- **Event**  
eye infection

**Reports**  
13

**Reporting signal score**

17.4097
- **Event**  
eye injury

**Reports**  
11

**Reporting signal score**

29.2452
- **Event**  
eye irritation

**Reports**  
486

**Reporting signal score**  
1,891.73

And 77 more, listed on the interactive page.

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

2

**Polar surface area**

133.99

**Calculated partition coefficient (ALogP)**

4.77

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

7

**Heavy atoms**

42

**Molecular formula**

C29H23Cl2N2NaO7S

**Monoisotopic mass**

636.0500719

**Natural product**

No

## Evidence counts

**Recorded assays**

1

**Active assays**

0

## Related records

### Trials (26)

- A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye
- A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
- A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE)
- [A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-a-fixed-dose-84bbf443-32bc-41dd-874c-453b479bc646.md)
- A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease
- A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects With Dry Eye Disease
- A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)
- Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days
- Effect of Lifitegrast 5% on Tear Film Markers
- Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms
- Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
- Efficacy Study to Evaluate the Effectiveness of 3 Concentrations of SAR 1118 in Allergic Conjunctivitis
- Examining the Clinical Characteristics, Treatment Patterns, Real-world Effectiveness, and Healthcare Resource Utilization of Patients With Dry Eye Disease
- Lifitegrast 5% for the Treatment of Dry Eye In Habitual Soft Contact Lens Wearers
- Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness
- Lifitegrast Eye Drops in Healthy Subjects：Phase I Study
- Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra
- Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)
- Safety Study of Lifitegrast to Treat Dry Eye
- The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study

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