> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lepodisiran-8b0f52c0-9390-4d13-a122-cdbe797db75f
> Record changed: 2026-10-13

# Lepodisiran

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

Drug type

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

## Names and chemistry

**Drug type**

Oligonucleotide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

**Drug name**

Lepodisiran

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

### Other names (18)

- duplex of all p ambo 4 de hydroxymethyl 4 hydroxymethylphosphinoyl methoxy 2 o methylthiouridylyl 2 deoxy 2 fluorothioadenylyl 3 5 2 deoxy 2 fluorothioguanylyl 3 5 2 deoxy 2 fluoroadenylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 o methylguanylyl 3 5 2 deoxy 2 fluoroadenylyl 3 5 2 o methylcytidylyl 3 5 2 o methylcytidylyl 3 5 2 deoxy 2 fluoroadenylyl 3 5 2 o methyladenylyl 3 5 2 o methylguanylyl 3 5 2 o methylcytidylyl 3 5 2 deoxy 2 fluorouridylyl 3 5 2 o methyluridylyl 3 5 2 o methylguanylyl 3 5 2 o methylguanylyl 3 5 2 o methylcytidylyl 3 5 2 o methyladenylyl 3 5 2 o methylthioadenylyl 3 5 2 o methylthioguanylyl 3 5 2 o methylguanosine and all p ambo 2 o methylthiouridylyl 5 3 2 o methyluridylyl 5 3 2 o methylguanylyl 5 3 2 o methylcytidylyl 5 3 2 o methylcytidylyl 5 3 2 o methyladenylyl 5 3 2 o methyladenylyl 5 3 2 deoxy 2 fluoroguanylyl 5 3 2 deoxy 2 fluorocytidylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 deoxy 2 fluorouridylyl 5 3 2 o methylguanylyl 5 3 2 o methylguanylyl 5 3 2 o methyluridylyl 5 3 2 o methylcytidylyl 5 3 2 o methyladenylyl 5 3 2 o methyluridylyl 5 3 2 o methylcytidylyl 5 3 2 o methyluridylyl 5 3 2 o methyladenylyl 5 3 2 o methylguanylyl 5 3 2 o methylcytidylyl 5 3 2 o methyladenylyl 5 3 2 o methylguanylyl 5 3 2 o methylcytidylyl 5 3 2 o methylcytidylyl 5 3 2 o methylguanylyl 5 3 2 2 5 2 acetamido 2 deoxy b d galactopyranosyl oxy pentanamido ethoxy ethoxy methyl adenylyl 5 3 2 2 5 2 acetamido 2 deoxy b d galactopyranosyl oxy pentanamido ethoxy ethoxy methyl adenylyl 5 3 2 2 5 2 acetamido 2 deoxy b d galactopyranosyl oxy pentanamido ethoxy ethoxy methyl adenylyl 5 3 2 o methylguanylyl 5 3 2 o methylguanylyl 5 3 2 o methylcytidylyl 5 3 2 o methyluridylyl 5 3 2 o methylguanylyl 5 3 2 o methylcytosine
- duplex of all-P-ambo-4′-de(hydroxymethyl)-4′-\[(hydroxymethylphosphinoyl)methoxy\]-2′-O-methylthiouridylyl-2′-deoxy-2′-fluorothioadenylyl-(3'→5')-2′-deoxy-2′-fluorothioguanylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-deoxy-2′-fluorouridylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-O-methyladenylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-deoxy-2′-fluorouridylyl-(3'→5')-2′-O-methyluridylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-O-methyladenylyl-(3'→5')-2′-O-methylthioadenylyl-(3'→5')-2′-O-methylthioguanylyl-(3'→5')-2′-O-methylguanosine and all-P-ambo-2′-O-methylthiouridylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-deoxy-2′-fluoroguanylyl-(5′→3′)-2′-deoxy-2′-fluorocytidylyl-(5′→3′)-2′-deoxy-2′-fluorouridylyl-(5′→3′)-2′-deoxy-2′-fluorouridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-{2-\[2-{5-\[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy\]pentanamido}ethoxy)ethoxy\]methyl}adenylyl-(5′→3′)-{2-\[2-{5-\[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy\]pentanamido}ethoxy)ethoxy\]methyl}adenylyl-(5′→3′)-{2-\[2-{5-\[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy\]pentanamido}ethoxy)ethoxy\]methyl}adenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytosine
- lepodisiran
- Lepodisiran
- lepodisiran \[INN\]
- LEPODISIRAN \[USAN\]
- Lepodisiran \[WHO-DD\]
- lepodisiran inn
- lepodisiran usan
- lepodisiran who dd
- ly 3819469 free acid
- LY-3819469 FREE ACID
- ly3819469
- LY3819469
- ly3819469 free acid
- LY3819469 FREE ACID
- rna 4 de hydroxymethyl 4 hydroxymethoxyphosphinyl methoxy um sp 2 deoxy 2 fluoro a sp 2 deoxy 2 fluoro g sp 2 deoxy 2 fluoro a 2 deoxy 2 fluoro u gm 2 deoxy 2 fluoro a cm cm 2 deoxy 2 fluoro a am gm cm 2 deoxy 2 fluoro u um gm gm cm am am sp gm sp gm complex with rna um sp um gm cm cm am am 2 deoxy 2 fluoro g 2 deoxy 2 fluoro c 2 deoxy 2 fluoro u 2 deoxy 2 fluoro u gm gm um cm am um cm um am gm cm am gm cm cm gm 2 o 2 2 5 2 acetylamino 2 deoxy β d galactopyranosyl oxy 1 oxopentyl amino ethoxy ethoxy methyl a 2 o 2 2 5 2 acetylamino 2 deoxy β d galactopyranosyl oxy 1 oxopentyl amino ethoxy ethoxy methyl a 2 o 2 2 5 2 acetylamino 2 deoxy β d galactopyranosyl oxy 1 oxopentyl amino ethoxy ethoxy methyl a gm gm cm um gm cm 1 1
- RNA, (\[4′-de(hydroxymethyl)-4′-\[(hydroxymethoxyphosphinyl)methoxy\]\]Um-sp-(2′-deoxy-2′-fluoro)A-sp-(2′-deoxy-2′-fluoro)G-sp-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)A-Cm-Cm-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-(2′-deoxy-2′-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-\[2′-O-\[\[2-\[2-\[\[5-\[\[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl\]oxy\]-1-oxopentyl\]amino\]ethoxy\]ethoxy\]methyl\]\]A-\[2′-O-\[\[2-\[2-\[\[5-\[\[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl\]oxy\]-1-oxopentyl\]amino\]ethoxy\]ethoxy\]methyl\]\]A-\[2′-O-\[\[2-\[2-\[\[5-\[\[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl\]oxy\]-1-oxopentyl\]amino\]ethoxy\]ethoxy\]methyl\]\]A-Gm-Gm-Cm-Um-Gm-Cm) (1:1)

## Identifiers

**CAS registry numbers**

- 2808361-18-2

**ChEMBL ID**

CHEMBL6068445

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068445)

**FDA ingredient codes (UNII)**

- X4BE7S8PN9

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

lepodisiran

**Type**

Nucleic acid

### Investigated indications

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0000319
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001410

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004995

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences

- **Component**  
Sequence

**Type**  
Nucleic Acid

**Sequence**  
(5'-3') U=U-G-C-A-A-G-C-U-U-G-G-U-C-A-U-C-U-A-G-C-A-G-C-C-G (3'-5') G=G=A-A-C-G-U-U-C-G-A-A-C-C-A-G-U-A=G=A=U-C-G-U-C-G-G

## Related records

### Trials (6)

- A Study of Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function
- A Study of LY3819469 in Healthy Participants
- [A Study of LY3819469 in Participants With Elevated Lipoprotein(a) \[Lp(a)\]](https://trialight.com/data/trial/a-study-of-ly3819469-in-participants-with-elevated-e06eb494-8b89-4757-9b4c-e00000b0e581.md)
- A Study of LY3819469 in Participants With Impaired and Normal Renal Function
- A Study to Compare Two Formulations of LY3819469 in Healthy Participants
- A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

### In development for (2)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1

---

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