> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/lead-212pb-lapemelanotide-zapixetan-82560faa-5049-4cd7-b45c-90ff103d246c
> Record changed: 2026-10-13

# Lead (212PB) lapemelanotide zapixetan

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

**Drug name**

Lead (212PB) lapemelanotide zapixetan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

**Molecular weight**

1,916.95

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

### Other names (6)

- Lead (212pb) lapemelanotide zapixetan
- lead 212pb lapemelanotide zapixetan
- Plomb (212pb) lapemelanotide zapixetan
- plomb 212pb lapemelanotide zapixetan
- Plomo (212pb) lapemelanotide zapixetan
- plomo 212pb lapemelanotide zapixetan

## Identifiers

**ChEMBL ID**

CHEMBL6068068

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068068)

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-tide; -xetan

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (2)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

123

**Molecular formula**

C79H117N25O18Pb

**Natural product**

No

## Related records

### Trials (9)

- \[212Pb\]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers
- A Safety Study of 212Pb-VMT-alpha-NET in Patients With Neuroendocrine Tumors
- [A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)](https://trialight.com/data/trial/a-study-to-investigate-cea-prit-2-0-in-participants-with-b87088a0-f8eb-406c-b542-fe21ff0b13aa.md)
- Lead-212 PSV359 Therapy for Patients With Solid Tumors
- MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
- Phase 0/1 Study of 212Pb-NG001 in mCRPC
- Somatostatin-Receptors (SSTR)-Agonist \[212Pb\]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy
- Study of \[212Pb\]Pb-DOTAM-MAM279 (\[212Pb\]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors
- Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors

### In development for (1)

- Neoplasm Phase 2

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