> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lazertinib-mesylate-6e43140e-9e73-4520-9ea0-544e8808c3bb > Record changed: 2026-10-13 # Lazertinib mesylate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) First approval year 2024 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) ## Development status **First approval year** 2024 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **Drug name** Lazertinib mesylate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **Molecular weight** 668.78 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **Structure (SMILES)** C=CC(=O)Nc1cc(Nc2nccc(-n3cc(CN(C)C)c(-c4ccccc4)n3)n2)c(OC)cc1N1CCOCC1.CS(=O)(=O)O.O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) ### Brand names (4) - lazcluze - Lazcluze - leclaza - Leclaza ### Other names (24) - jnj 73841937 zcy - JNJ-73841937-ZCY - lazcluze - Lazcluze - lazertinib mesilate hydrate - Lazertinib mesilate hydrate - LAZERTINIB MESILATE HYDRATE \[JAN\] - lazertinib mesilate hydrate jan - lazertinib mesylate - Lazertinib mesylate - LAZERTINIB MESYLATE \[USAN\] - lazertinib mesylate monohydrate - Lazertinib mesylate monohydrate - Lazertinib mesylate monohydrate \[MI\] - Lazertinib mesylate monohydrate \[WHO-DD\] - lazertinib mesylate monohydrate mi - lazertinib mesylate monohydrate who dd - lazertinib mesylate usan - r 605024 - R-605024 - r605024 - R605024 - yh25448am - YH25448AM ## Identifiers **ATC classification codes** - L01EB09 Sources for recorded values Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2691150) **CAS registry numbers** - 2411549-88-5 **ChEMBL ID** CHEMBL6068478 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **InChIKey** ZJPNGZUERUYZEG-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068478) **PubChem compound IDs** - 163203547 **RxNorm IDs (RxCUI)** - 2691150 **FDA ingredient codes (UNII)** - WUT449BEG5 ## Regulatory information ### United States **Applicant** JANSSEN BIOTECH **Approval date** 19 Aug 2024 **Application number** NDA219008 ### Other regulatory facts **Patents** 7 **Designations** 0 **Earliest recorded loss of exclusivity** 1 Aug 2041 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-tinib #### Administration routes - Oral ### Mechanisms of action - **Mechanism** Epidermal growth factor receptor erbB1 inhibitor **Action type** Inhibitor **Target** Epidermal growth factor receptor **Protein identifier** P00533 ### Open Targets mechanisms - **Mechanism** Epidermal growth factor receptor erbB1 inhibitor **Action type** Inhibitor **Target** Epidermal growth factor receptor ### Investigated indications (2) - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 4 **Condition identifier** EFO:0003060 **Subject identifier** D002289 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0003060 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 4 ### Reported adverse events (4) - **Event** embolism venous **Reports** 2 **Reporting signal score** 8.68753 - **Event** infusion related reaction **Reports** 7 **Reporting signal score** 21.1031 - **Event** paronychia **Reports** 3 **Reporting signal score** 13.3184 - **Event** skin disorder **Reports** 4 **Reporting signal score** 13.9953 ## Chemical properties **Hydrogen bond acceptors** 10 **Hydrogen bond donors** 2 **Polar surface area** 109.67 **Calculated partition coefficient (ALogP)** 4.1 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 10 **Heavy atoms** 47 **Molecular formula** C31H40N8O7S **Monoisotopic mass** 668.27406682 **Natural product** No ## Related records ### Trials (40) - A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker - A Study of (14C)-JNJ-73841937 (Lazertinib) in Healthy Male Participants - A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer - A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure - A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC) - [A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)](https://trialight.com/data/trial/a-study-of-amivantamab-in-combination-with-lazertinib-or-811742ea-fa47-4825-bf2b-6fdcf23f2f3b.md) - [A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-study-of-amivantamab-in-participants-with-advanced-or-09b1a702-38c7-4424-810b-385b505d2bb7.md) - A Study of Four Different Oral Tablet Formulations of Lazertinib (JNJ-73841937) in Healthy Adult Participants - A Study of Lazertinib (JNJ-73841937) in Healthy Participants - A Study of Lazertinib (JNJ-73841937) Tablet in Healthy Adult Participants - A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy - A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer - A Study of Lazertinib in Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Positive Advanced Non-Small Cell Lung Cancer (NSCLC) - A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer - A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC - A Study to Assess the Effects of Itraconazole and Rifampin on Lazertinib in Healthy Adult Participants - A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937) - Amivantamab, Lazertinib and Bevacizumab in Patients With EGFR-mutant Advanced Non-small Cell Lung Cancer With Progression on Previous Third-generation EGFR-TKI - Amivantamab, Lazertinib, and Pemetrexed for First-line Treatment of Recurrent/Metastatic Non-small Cell Lung Cancers With Epidermal Growth Factor Receptor Mutations - Clinical Trial of YH25448(Lazertinib) as the First-line Treatment in Patients With EGFR Mutation Positive Locally Advanced or Metastatic NSCLC (LASER301) ### Approved for (1) - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) ### In development for (1) - Neoplasm Phase 1 ### Targets (1) - [EGFR](https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7.md) Epidermal growth factor receptor erbB1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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