> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/latanoprost-70b1bf55-247c-476b-a7ee-5a056ee0cddd > Record changed: 2026-10-13 # Latanoprost Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) First approval year 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) ## Development status **First approval year** 1996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **Drug name** Latanoprost Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **Molecular weight** 432.6 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **Structure (SMILES)** CC(C)OC(=O)CCC/C=C\\C\[C@@H\]1\[C@@H\](CC\[C@@H\](O)CCc2ccccc2)\[C@H\](O)C\[C@@H\]1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) ### Brand names (16) - catiolanze - Catiolanze - iyuzeh - Iyuzeh - latanoprost - Latanoprost - latanoprost component of rocklatan - Latanoprost component of rocklatan - latanoprost component of xalacom - Latanoprost component of xalacom - monopost - Monopost - xalatan - Xalatan - xelpros - Xelpros ### Other names (69) - 5 heptenoic acid 7 3 5 dihydroxy 2 3 hydroxy 5 phenylpentyl cyclopentyl 1 methylethyl ester 1r 1 alpha z 2 beta r 3 alpha 5 alpha - 5-HEPTENOIC ACID, 7-(3,5-DIHYDROXY-2-(3-HYDROXY-5-PHENYLPENTYL)CYCLOPENTYL)-1-METHYLETHYL ESTER, (1R-(1.ALPHA.(Z),2.BETA.(R\*),3.ALPHA.,5.ALPHA.))- - bimatoporost latanoprost - Bimatoporost-Latanoprost - iyuzeh - Iyuzeh - latanoprost - Latanoprost - Latanoprost (isopropyl ester) - Latanoprost (Xalatan) - LATANOPROST \[EP MONOGRAPH\] - latanoprost \[INN\] - LATANOPROST \[JAN\] - LATANOPROST \[MART.\] - LATANOPROST \[MI\] - LATANOPROST \[ORANGE BOOK\] - LATANOPROST \[USAN\] - LATANOPROST \[USP MONOGRAPH\] - LATANOPROST \[USP-RS\] - LATANOPROST \[VANDF\] - Latanoprost \[WHO-DD\] - latanoprost 0.005% (Xalatan) - Latanoprost 0.005% ophthalmic solution (Xalatan) - Latanoprost 0.005% Ophthalmic Solution (XALATAN) - Latanoprost 0.005%, Xalatan® And 44 more, listed on the interactive page. ## Identifiers **ATC classification codes** - S01EE01 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **CAS registry numbers** - 130209-82-4 **ChEMBL ID** CHEMBL1051 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **InChIKey** GGXICVAJURFBLW-CEYXHVGTSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1051) **PubChem compound IDs** - 5311221 **RxNorm IDs (RxCUI)** - 43611 **FDA ingredient codes (UNII)** - 6Z5B6HVF6O ## Regulatory information ### United States **Applicant** UPJOHN **Approval date** 5 Jun 1996 **Application number** NDA020597 ### European Union **Status** Authorised **Status date** 15 Nov 2023 **Authorisation date** 15 Nov 2023 **Approved indications** Catiolanze is indicated for the reduction of elevated intraocular pressure (IOP) in adult patients with open angle glaucoma or ocular hypertension. Catiolanze is indicated for the reduction of elevated IOP in children from 4 years of age and adolescents with elevated IOP and paediatric glaucoma. **Product number** EMEA/H/C/005933 **Authorisation holder** Santen Oy **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Glaucoma, Open-Angle European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/catiolanze) ### Other regulatory facts **Patents** 3 **Designations** 1 **Earliest recorded loss of exclusivity** 8 Jul 2031 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** latanoprost (isopropyl ester) **Type** Synthetic organic **Drug name stem** \-prost **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - topical ### Mechanisms of action (2) - **Mechanism** Prostanoid FP receptor agonist **Action type** Agonist **Target** Prostaglandin F2-alpha receptor **Protein identifier** P43088 - **Action** Full agonist **Action type** FULL\_AGONIST **Target** FP receptor **Gene symbol** PTGFR **Protein identifier** P43088 **Median affinity** 6.3 **Affinity units** pKi **Primary target** Yes ### Open Targets mechanisms - **Mechanism** Prostanoid FP receptor agonist **Action type** Agonist **Target** Prostaglandin F2-alpha receptor ### DrugCentral mechanisms - **Action type** Agonist **Gene symbol** PTGFR **Protein identifier** P43088 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (7) - **Condition** Hypertension **Highest recorded phase** 4 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Glaucoma, Open-Angle **Highest recorded phase** 4 **Condition identifier** EFO:0004190 **Subject identifier** D005902 - **Condition** Alopecia Areata **Highest recorded phase** 1 **Condition identifier** EFO:0004192 **Subject identifier** D000506 - **Condition** Vitiligo **Highest recorded phase** 2 **Condition identifier** EFO:0004208 **Subject identifier** D014820 - **Condition** Meniere Disease **Highest recorded phase** 2 **Condition identifier** EFO:0006862 **Subject identifier** D008575 - **Condition** Ocular Hypertension **Highest recorded phase** 4 **Condition identifier** EFO:1001069 **Subject identifier** D009798 - **Condition** Glaucoma **Highest recorded phase** 4 **Condition identifier** MONDO:0005041 **Subject identifier** D005901 ### Open Targets indications (21) - **Condition identifier** EFO\_0000537 - **Condition identifier** EFO\_0004190 - **Condition identifier** EFO\_0004192 - **Condition identifier** EFO\_0004208 - **Condition identifier** EFO\_0006862 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001069 - **Condition identifier** HP\_0045075 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001744 - **Condition identifier** MONDO\_0001966 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005041 - **Condition identifier** MONDO\_0005041 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005044 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005266 - **Condition identifier** MONDO\_0005338 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005339 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005340 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0006837 - **Condition identifier** MONDO\_0006875 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0007972 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008327 - **Condition identifier** MONDO\_0008661 **Highest recorded phase** 2 ### Reported adverse events (47) - **Event** blepharitis **Reports** 39 **Reporting signal score** 97.6774 - **Event** blindness **Reports** 82 **Reporting signal score** 92.4217 - **Event** cataract **Reports** 146 **Reporting signal score** 205.934 - **Event** cataract operation **Reports** 32 **Reporting signal score** 64.9805 - **Event** choroidal detachment **Reports** 26 **Reporting signal score** 84.5608 - **Event** choroidal effusion **Reports** 29 **Reporting signal score** 90.6407 - **Event** conjunctival hyperaemia **Reports** 48 **Reporting signal score** 113.487 - **Event** corneal disorder **Reports** 39 **Reporting signal score** 108.558 - **Event** corneal oedema **Reports** 30 **Reporting signal score** 64.4767 - **Event** corneal opacity **Reports** 25 **Reporting signal score** 65.3457 - **Event** cystoid macular oedema **Reports** 33 **Reporting signal score** 81.8376 - **Event** diarrhoea **Reports** 36 **Reporting signal score** 113.166 - **Event** dry eye **Reports** 120 **Reporting signal score** 197.038 - **Event** erythema of eyelid **Reports** 34 **Reporting signal score** 76.9022 - **Event** eye allergy **Reports** 25 **Reporting signal score** 87.8595 - **Event** eye discharge **Reports** 36 **Reporting signal score** 65.6973 - **Event** eye disorder **Reports** 101 **Reporting signal score** 170.12 - **Event** eye irritation **Reports** 649 **Reporting signal score** 2,177.95 - **Event** eye pain **Reports** 363 **Reporting signal score** 931.179 - **Event** eye pruritus **Reports** 142 **Reporting signal score** 307.851 - **Event** eye swelling **Reports** 79 **Reporting signal score** 98.9926 - **Event** fatigue **Reports** 46 **Reporting signal score** 108.315 - **Event** foreign body sensation in eyes **Reports** 70 **Reporting signal score** 223.499 - **Event** glaucoma **Reports** 176 **Reporting signal score** 440.033 - **Event** growth of eyelashes **Reports** 34 **Reporting signal score** 147.565 And 22 more, listed on the interactive page. ### Trial references (71) - NCT00051142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051142) - NCT00051155 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051155) - NCT00051181 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051181) - NCT00150267 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00150267) - NCT00159653 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00159653) - NCT00219596 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00219596) - NCT00230763 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00230763) - NCT00277498 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00277498) - NCT00283764 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00283764) - NCT00293787 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293787) - NCT00293800 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293800) - NCT00311389 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00311389) - NCT00650338 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00650338) - NCT00751127 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00751127) - NCT00868894 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00868894) - NCT01162603 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01162603) - NCT01223378 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01223378) - NCT01229982 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01229982) - NCT01655758 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01655758) - NCT01896180 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01896180) - NCT01917383 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01917383) - NCT01987323 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01987323) - NCT02014142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02014142) - NCT02531152 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02531152) - NCT02829996 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02829996) And 46 more, listed on the interactive page. ## Dosing **Dose** One drop **Route** Topical **How often** Once daily ### Conditions of use (2) - Remove contact lenses before use - Wait 15 minutes after administration to reinsert contact lenses ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 3 **Polar surface area** 86.99 **Calculated partition coefficient (ALogP)** 4.19 **Calculated partition coefficient (XLogP)** 4.3 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 13 **Heavy atoms** 31 **Molecular formula** C26H40O5 **Monoisotopic mass** 432.28757437 **Natural product** Yes ## National Drug Codes - 24208-463 - 25021-001 - 42571-499 - 47335-317 - 58151-419 - 61314-547 - 64980-516 - 65862-872 - 68083-609 - 68462-944 - 70069-421 - 70756-680 - 71205-154 - 82584-003 - 50090-1920 - 50090-7062 - 59762-0333 - 68071-2376 - 68071-3884 ## Evidence counts **Recorded assays** 447 **Active assays** 10 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Ophthalmic Solutions Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D009883.html) ## Related records ### Trials (230) - 0.005% Latanoprost Gel for Nonsegmental Vitiligo - 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension - 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients - 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients - 24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice - 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations - 24-hr IOP With Travoprost/Timolol Compared With Latanoprost/Timolol in XFG - 28-Day Repeated Topical Study to Evaluate the Safety and Activity of 5 Escalating Dose Levels of SAR366234 and One Dose of Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension - A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma - A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension - A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma - A 12-Week, Randomized, Double-Masked, Parallel Group Comparison Of Evening Dosing With Xalacom In Subjects With Glaucoma - A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma - A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG) - A 5-Year Postmarketing Safety Study Of Xalcom In Patients With Open Angle Glaucoma Or Ocular Hypertension - A 6 Month Study Comparing Latanoprost With Timolol in Patients With Open Angle Glaucoma or Ocular Hypertension - A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT) - A Clinical Study to Evaluate the Efficacy and Safety of CKD-351 - A Clinical Study to Evaluate the Efficacy and Safety of CKD-351 - A Clinical Trial Comparing the OMNI Surgical System to Standard Medical Treatment in Patients With Primary Open Angle Glaucoma ### Approved for (4) - [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md) - [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) - [Ocular hypertension](https://trialight.com/data/condition/ocular-hypertension-754666dc-b494-5a18-a3ee-6a2d941c65dd.md) - [Open-angle glaucoma](https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2.md) ### In development for (3) - [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 1 - Meniere disease Phase 2 - Vitiligo Phase 2 ### Targets (1) - [PTGFR](https://trialight.com/data/target/ptgfr-83fefc82-9ff1-5dc0-bef4-0577cb8c0adb.md) Prostanoid FP receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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