> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/laroprovstat-66e6da5b-2260-456c-8dca-4a4b86359a87 > Record changed: 2026-10-13 # Laroprovstat Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) **Drug name** Laroprovstat Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) **Molecular weight** 414.42 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) **Structure (SMILES)** O=c1ccccn1-c1ccc(N\[C@H\]2CC\[C@H\](Nc3ncc(OC(F)F)cn3)C2)nc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) ### Other names (23) - az 14232880 - AZ-14232880 - az14232880 - AZ14232880 - azd 0780 - AZD 0780 \[WHO-DD\] - azd 0780 who dd - AZD-0780 - azd0780 - AZD0780 - AZD0780 tablet - cr 000501656 - CR-000501656 - cr000501656 - CR000501656 - dgm 1656 - DGM-1656 - laroprovstat - Laroprovstat - laroprovstat \[INN\] - LAROPROVSTAT \[USAN\] - laroprovstat inn - laroprovstat usan ## Identifiers **CAS registry numbers** - 2455427-91-3 **ChEMBL ID** CHEMBL5404296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) **InChIKey** NCHUWRLOTSAFFN-KBPBESRZSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5404296) **PubChem compound IDs** - 154653847 **FDA ingredient codes (UNII)** - 9EEL3YMY29 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** laroprovstat **Type** Synthetic organic **Drug name stem** \-stat ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** proprotein convertase subtilisin/kexin type 9 **Gene symbol** PCSK9 **Protein identifier** Q8NBP7 **Median affinity** 6.7 **Affinity units** pKd ### Investigated indications - **Condition** Hyperlipidemias **Highest recorded phase** 2 **Condition identifier** MONDO:0021187 **Subject identifier** D006949 ### Open Targets indications (3) - **Condition identifier** HP\_0003124 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002525 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0021187 ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 2 **Polar surface area** 93.96 **Calculated partition coefficient (ALogP)** 3.07 **Calculated partition coefficient (XLogP)** 3.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 30 **Molecular formula** C20H20F2N6O2 **Monoisotopic mass** 414.16158023 **Natural product** No ## Evidence counts **Recorded assays** 3 **Active assays** 3 ### Active assay types - Confirmatory ## Related records ### Trials (21) - A Phase I Study Comparing the Relative Bioavailability of a Fixed-Dose Combination of Laroprovstat/Rosuvastatin vs Their Single Therapy Products in Healthy Adults - A Phase I Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD0780 - A Phase I, Cross-over Study Comparing the Relative Bioavailability of Laroprovstat Plus Ezetimibe Fixed Combination Drug Products Versus Their Single Therapy Products in Healthy Adults - [A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event](https://trialight.com/data/trial/a-phase-iii-study-of-azd0780-on-major-adverse-cv-events-in-5e5f32c2-ae57-4643-8e95-c187d7226004.md) - [A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event](https://trialight.com/data/trial/a-phase-iii-study-to-assess-the-effect-of-azd0780-on-ldl-c-33a9a0e9-878f-4170-b02c-4e45ef521bbe.md) - A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH - A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients. - A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Rosuvastatin on LDL-C in Patients With Hypercholesterolaemia - A Study to Assess the Effect of AZD0780 on Ambulatory Blood Pressure - A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy Adults - A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin. - [A Study to Assess the Efficacy, Safety and Tolerability of Different Doses of AZD0780 in Patients With Dyslipidemia](https://trialight.com/data/trial/a-study-to-assess-the-efficacy-safety-and-tolerability-of-2f806fb7-5431-40b3-be91-0f48a877aef3.md) - [A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 in Healthy Subjects](https://trialight.com/data/trial/a-study-to-assess-the-safety-tolerability-pharmacokinetics-34d13e64-837c-436c-aba7-718f6d3c344e.md) - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of AZD0780 in Participants With Dyslipidaemia - A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics With AZD0780 Following Repeated Dose Administration in Healthy Adults With Elevated LDL-C Levels - A Study to Investigate the Effect of AZD0780 on Metformin Pharmacokinetics in Healthy Adult Volunteers Aged 18 to 55 Years - A Study to Investigate the Effect of AZD0780 Tablets in Combination With Rosuvastatin Tablets on Low Density Lipoprotein Cholesterol Levels (LDL-C) in Adult Participants With Dyslipidaemia - A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C. - An ADME Study of \[14C\]AZD0780 in Healthy Male Subjects - An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug Interactions ### In development for (1) - Hyperlipidemia Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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