> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lanerkitug-3fc9bc27-3bd1-40c7-8b66-366fadd925fa > Record changed: 2026-11-04 # Lanerkitug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) **Drug name** Lanerkitug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) ### Other names (18) - bay 3375968 - BAY 3375968 - BAY 3375968 \[WHO-DD\] - bay 3375968 who dd - BAY-3375968 - bay3375968 - h gamma1 heavy chain homo sapiens 1 452 vh homo sapiens ighv3 23 01 92 9 ighd ighj4 01 93 3 8 8 15 26 33 51 58 97 111 1 122 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 ch3 d12 l14 ch1 k120 219 123 220 hinge 1 15 221 235 ch2 236 345 ch3 d12 361 l14 363 346 450 chs 451 452 123 452 225 216 disulfide with l lambda2 light chain homo sapiens 1 217 v lambda homo sapiens iglv1 47 02 89 9 iglj3 02 100 cdr imgt 9 3 11 26 34 52 54 91 101 1 111 homo sapiens iglc2 01 100 112 217 dimer 231 231 234 234 bisdisulfide produced in chinese hamster ovary cho cells derived from cho k1 cell line lacking the glutamine synthetase gs ko gene and co expressing the rmd enzyme gdp 6 deoxy d lyxo 4 hexulose reductase glycoform alfa - H-gamma1 heavy chain Homo sapiens (1-452) \[VH(Homo sapiens IGHV3-23\*01 (92.9%) -(IGHD) -IGHJ4\*01 (93.3%)) \[8.8.15\] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG1\*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS (451-452)) (123-452)\], (225-216')-disulfide with L-lambda2 light chain Homo sapiens (1'-217') \[V-LAMBDA (Homo sapiens IGLV1-47\*02 (89.9%) -IGLJ3\*02 (100%), CDR-IMGT \[9.3.11\](26'-34'.52'-54'.91'-101')) (1'-111') -Homo sapiens IGLC2\*01 (100%) (112'-217')\]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, and co-expressing the RMD enzyme (GDP-6-deoxy-D-lyxo-4-hexulose reductase), glycoform alfa - immunoglobulin g1 anti human cc chemokine receptor ccr8 human monoclonal bay 3375968 γ1 chain disulfide with human monoclonal bay 3375968 λ chain dimer - immunoglobulin g1 lambda2 anti homo sapiens ccr8 c c motif chemokine receptor 8 ckr l1 cdw198 homo sapiens monoclonal antibody - immunoglobulin G1-lambda2, anti-\[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)\], Homo sapiens monoclonal antibody - Immunoglobulin G1, anti-(human CC chemokine receptor CCR8) (human monoclonal BAY 3375968 γ1-chain), disulfide with human monoclonal BAY 3375968 λ-chain, dimer - lanerkitug - Lanerkitug - lanerkitug \[INN\] - LANERKITUG \[USAN\] - lanerkitug inn - lanerkitug usan ## Identifiers **CAS registry numbers** - 2839417-54-6 **ChEMBL ID** CHEMBL6068127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068127) **FDA ingredient codes (UNII)** - DNV66ACK7K ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (7) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005627 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008903 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVSAINWNGGSTGYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGHHSGYDGRFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22'-90' $ 22'''-90''' $ 22-96 $ 22''-96'' $ 139'-198' $ 139'''-198''' $ 149-205 $ 149''-205'' $ 225-216' $ 225''-216''' $ 231-231'' $ 234-234'' $ 266-326 $ 266''-326'' $ 372-430 $ 372''-430'' - **Component** Light chain **Type** Protein **Sequence** QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYNVHWYQQLPGTAPKLLIYTNNRRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDASLSGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'' ## Related records ### Trials (1) - [A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-first-in-human-study-to-learn-how-safe-the-study-drug-6c792c25-893b-420e-9576-1f0f06e7df43.md) ### In development for (6) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 1 - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) Phase 1 - [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 1 - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 1 - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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