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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lancastotug-ec93520a-b3d1-4694-bfb1-e3666a4600e2 > Record changed: 2026-10-13 # Lancastotug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) **Drug name** Lancastotug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) ### Other names (18) - ak 127 - Ak 127 - AK-127 - ak127 - Ak127 - AK127 - Gamma1 heavy chain humanized (1-451) \[VH (Homo sapiens IGHV4-30-4\*01 (90.8%) -(IGHD) -IGHJ4\*01 (92.3%) L123>S (116), CDR-IMGT \[9.7.14\] (26-34.52-58.97-110)) (1-121) -Homo sapiens IGHG1\*03v,G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14 (CH1R120>K (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451))(122-451)\], (224-214')-disulfide with kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV1-9\*03 (85.4%) -IGKJ4\*01 (90.9%) V124>L (104), CDR-IMGT \[6.3.9\] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')\]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - gamma1 heavy chain humanized 1 451 vh homo sapiens ighv4 30 4 01 90 8 ighd ighj4 01 92 3 l123 s 116 cdr imgt 9 7 14 26 34 52 58 97 110 1 121 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 ch1r120 k 218 122 219 hinge 1 15 220 234 ch2 235 344 ch3 e12 360 m14 362 345 449 chs 450 451 122 451 224 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 9 03 85 4 igkj4 01 90 9 v124 l 104 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 230 230 233 233 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - immunoglobulin g1 anti human receptor tigit human mus musculus monoclonal ak127 γ1 chain disulfide with human mus musculus monoclonal ak127 κ chain dimer - Immunoglobulin G1, anti-(human receptor TIGIT) (human-Mus musculus monoclonal AK127 γ1-chain), disulfide with human-Mus musculus monoclonal AK127 κ-chain, dimer - lancastotug - Lancastotug - lancastotug \[INN\] - Lancastotug \[WHO-DD\] - lancastotug inn - lancastotug who dd - mmunoglobulin g1 kappa anti homo sapiens tigit t cell immunoreceptor with ig domain and itim v set ig member 9 vsig9 v set and transmembrane member 3 vstm3 humanized monoclonal antibody - mmunoglobulin G1-kappa, anti-\[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)\], humanized monoclonal antibody ## Identifiers **CAS registry numbers** - 2768355-20-8 **ChEMBL ID** CHEMBL5314843 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314843) **FDA ingredient codes (UNII)** - JP3KZB9R7C ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (4) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0007256 **Highest recorded phase** 1 ### Trial references (2) - NCT05021120 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05021120) - NCT05393063 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05393063) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** DVQLQESGPGLVKPSQTLSLTCTVSGHSFTSDYAWSWIRQPPGKGLEWIGYISYSDSTNYNPSLKSRVTISRDTSKNQFSLKLSSVTAADTAVYYCARLDYGNYGGAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRSSQHVSTALAWYQQKPGKSPKLLIYSASSRYSGVPDRFSGSGSGTDFTFTISSLQPEDFATYYCQQHYITPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 148-204 $ 148''-204'' $ 224-214' $ 224''-214''' $ 230-230'' $ 233-233'' $ 265-325 $ 265''-325'' $ 371-429 $ 371''-429'' - **Component** Glycosylation sites (N) **Sequence** 301 $ 301'' ## Related records ### Trials (5) - [A Phase Ia/Ib Open Label，Clinical Study Evaluating the Safety, Tolerability and Preliminary Efficacy of AK127 in Combination With AK104 in Patients With Advanced Malignant Tumors](https://trialight.com/data/trial/a-phase-ia-ib-open-label-clinical-study-evaluating-the-ea3d5cd1-0f2f-4382-8c25-855965404eab.md) - A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors - A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC) - A Study to Evaluate the Efficacy and Safety of AK127 in Patients With Advanced Solid Tumors - A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK127 in Combination With AK104 in Advanced and Metastatic Solid Tumours ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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