> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/lamotrigine-a3f82366-2b43-4bea-99ed-5496f51ebe15 > Record changed: 2026-11-04 # Lamotrigine Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) First approval year 1994 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) ## Development status **First approval year** 1994 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **Drug name** Lamotrigine Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **Molecular weight** 256.1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **Structure (SMILES)** Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) ### Brand names (10) - lamictal - Lamictal - lamictal cd - Lamictal cd - lamictal odt - Lamictal odt - lamictal xr - Lamictal xr - lamotrigine - Lamotrigine ### Other names (84) - 1 2 4 triazine 3 5 diamine 6 2 3 dichlorophenyl - 1,2,4-TRIAZINE-3,5-DIAMINE, 6-(2,3-DICHLOROPHENYL) - 3 5 diamino 6 2 3 dichlorophenyl as triazine - 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine - bw 430c - BW 430C - BW-430C - BW430C (lamotrigine) - bw430c lamotrigine - lamictal - Lamictal - Lamictal (lamotrigine) - lamictal extended release - lamictal lamotrigine - lamictal tablets 25 mg - Lamictal® - Lamictal® Tablets 25 mg - lamotrigina - Lamotrigina - lamotrigine - Lamotrigine - lamotrigine (brand Lamictal) - Lamotrigine (brand name vs generic drugs) - Lamotrigine (drug) - Lamotrigine (Drug) And 59 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N03AX09 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **CAS registry numbers** - 84057-84-1 **ChEMBL ID** CHEMBL741 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **InChIKey** PYZRQGJRPPTADH-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL741) **PubChem compound IDs** - 3878 **RxNorm IDs (RxCUI)** - 28439 **FDA ingredient codes (UNII)** - U3H27498KS ## Regulatory information ### United States **Applicant** GLAXOSMITHKLINE LLC **Approval date** 27 Dec 1994 **Application number** NDA020241 ### Other regulatory facts **Patents** 3 **Designations** 2 **Earliest recorded loss of exclusivity** 29 May 2040 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** lamotrigine **Type** Synthetic organic **Drug name stem** \-trigine **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (10) - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** P35498 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** P35499 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q01118 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q14524 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q15858 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q99250 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q9NY46 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q9UI33 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q9UQD0 - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit **Protein identifier** Q9Y5Y9 ### Open Targets mechanisms - **Mechanism** Sodium channel alpha subunit blocker **Action type** Blocker **Target** Sodium channel alpha subunit ### DrugCentral mechanisms (8) - **Action type** Blocker **Gene symbol** SCN1A **Protein identifier** P35498 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN4A **Protein identifier** P35499 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN5A **Protein identifier** Q14524 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN9A **Protein identifier** Q15858 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN2A **Protein identifier** Q99250 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN3A **Protein identifier** Q9NY46 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN8A **Protein identifier** Q9UQD0 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Blocker **Gene symbol** SCN10A **Protein identifier** Q9Y5Y9 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (32) - **Condition** Epilepsy **Highest recorded phase** 4 **Condition identifier** EFO:0000474 **Subject identifier** D004827 - **Condition** Mental Disorders **Highest recorded phase** 1 **Condition identifier** EFO:0000677 **Subject identifier** D001523 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Obesity **Highest recorded phase** 3 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Cocaine-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0002610 **Subject identifier** D019970 - **Condition** Fasting **Highest recorded phase** 1 **Condition identifier** EFO:0002756 **Subject identifier** D005215 - **Condition** Peripheral Nervous System Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0003100 **Subject identifier** D010523 - **Condition** Pain **Highest recorded phase** 3 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Substance-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0003890 **Subject identifier** D019966 - **Condition** Multiple Sclerosis, Relapsing-Remitting **Highest recorded phase** 2 **Condition identifier** EFO:0003929 **Subject identifier** D020529 - **Condition** Mood Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0004247 **Subject identifier** D019964 - **Condition** Epilepsies, Partial **Highest recorded phase** 4 **Condition identifier** EFO:0004263 **Subject identifier** D004828 - **Condition** Feeding and Eating Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0005203 **Subject identifier** D001068 - **Condition** Anxiety **Highest recorded phase** 3 **Condition identifier** EFO:0005230 **Subject identifier** D001007 - **Condition** Opioid-Related Disorders **Highest recorded phase** 2 **Condition identifier** EFO:0005611 **Subject identifier** D009293 - **Condition** Epilepsy, Tonic-Clonic **Highest recorded phase** 4 **Condition identifier** EFO:0007262 **Subject identifier** D004830 - **Condition** Multiple Sclerosis, Chronic Progressive **Highest recorded phase** 2 **Condition identifier** EFO:0008522 **Subject identifier** D020528 - **Condition** Bipolar Disorder **Highest recorded phase** 4 **Condition identifier** EFO:0009963 **Subject identifier** D001714 - **Condition** Dementia **Highest recorded phase** 3 **Condition identifier** HP:0000726 **Subject identifier** D003704 - **Condition** Seizures **Highest recorded phase** 4 **Condition identifier** HP:0001250 **Subject identifier** D012640 - **Condition** Epilepsy, Tonic-Clonic **Highest recorded phase** 4 **Condition identifier** HP:0002069 **Subject identifier** D004830 - **Condition** Cognitive Dysfunction **Highest recorded phase** 2 **Condition identifier** HP:0100543 **Subject identifier** D060825 - **Condition** Depressive Disorder **Highest recorded phase** 4 **Condition identifier** MONDO:0002009 **Subject identifier** D003866 - **Condition** Depressive Disorder **Highest recorded phase** 4 **Condition identifier** MONDO:0002050 **Subject identifier** D003866 - **Condition** Bipolar Disorder **Highest recorded phase** 4 **Condition identifier** MONDO:0004985 **Subject identifier** D001714 And 7 more, listed on the interactive page. ### Open Targets indications (64) - **Condition identifier** EFO\_0000474 - **Condition identifier** EFO\_0000677 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001073 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001074 - **Condition identifier** EFO\_0002610 **Highest recorded phase** 2 - **Condition identifier** EFO\_0002756 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003890 - **Condition identifier** EFO\_0003929 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004149 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004247 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004263 - **Condition identifier** EFO\_0005203 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005611 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007262 **Highest recorded phase** 3 - **Condition identifier** EFO\_0008522 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009963 - **Condition identifier** EFO\_0009963 **Highest recorded phase** 4 - **Condition identifier** EFO\_0009964 **Highest recorded phase** 3 - **Condition identifier** EFO\_0803536 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001219 - **Condition identifier** EFO\_1002051 - **Condition identifier** HP\_0001250 - **Condition identifier** HP\_0001250 **Highest recorded phase** 4 - **Condition identifier** HP\_0002069 - **Condition identifier** HP\_0002069 **Highest recorded phase** 4 And 39 more, listed on the interactive page. ### Warnings - **Warning** Black Box Warning **Effect** dermatological toxicity ### Open Targets warnings - **Warning** Black Box Warning **Effect** dermatological toxicity **Country** United States ### Reported adverse events (25) - **Event** abortion spontaneous **Reports** 449 **Reporting signal score** 385.677 - **Event** aggression **Reports** 377 **Reporting signal score** 306.49 - **Event** agitation **Reports** 502 **Reporting signal score** 322.812 - **Event** ataxia **Reports** 369 **Reporting signal score** 579.368 - **Event** atrial septal defect **Reports** 320 **Reporting signal score** 594.225 - **Event** coma **Reports** 505 **Reporting signal score** 512.879 - **Event** convulsion **Reports** 884 **Reporting signal score** 984.161 - **Event** diarrhoea **Reports** 244 **Reporting signal score** 322.817 - **Event** drug interaction **Reports** 1,057 **Reporting signal score** 496.113 - **Event** drug reaction with eosinophilia and systemic symptoms **Reports** 1,019 **Reporting signal score** 1,919.55 - **Event** epilepsy **Reports** 622 **Reporting signal score** 917.36 - **Event** generalised tonic-clonic seizure **Reports** 326 **Reporting signal score** 468.515 - **Event** lymphadenopathy **Reports** 388 **Reporting signal score** 407.654 - **Event** oral mucosa erosion **Reports** 121 **Reporting signal score** 341.13 - **Event** pyrexia **Reports** 1,481 **Reporting signal score** 531.588 - **Event** rash **Reports** 1,894 **Reporting signal score** 840.551 - **Event** rash maculo-papular **Reports** 432 **Reporting signal score** 526.132 - **Event** seizure **Reports** 925 **Reporting signal score** 919.601 - **Event** somnolence **Reports** 792 **Reporting signal score** 373.3 - **Event** status epilepticus **Reports** 264 **Reporting signal score** 383.54 - **Event** stevens-johnson syndrome **Reports** 970 **Reporting signal score** 2,057.76 - **Event** suicide attempt **Reports** 683 **Reporting signal score** 609.165 - **Event** toxic epidermal necrolysis **Reports** 518 **Reporting signal score** 1,058.89 - **Event** toxicity to various agents **Reports** 977 **Reporting signal score** 732.639 - **Event** ventricular septal defect **Reports** 208 **Reporting signal score** 389.95 ### Trial references (99) - NCT00000192 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000192) - NCT00007670 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00007670) - NCT00088452 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00088452) - NCT00144872 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00144872) - NCT00015106 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00015106) - NCT00043875 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00043875) - NCT00043914 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00043914) - NCT00044278 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00044278) - NCT00113165 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00113165) - NCT00137709 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00137709) - NCT00242606 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00242606) - NCT00264615 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00264615) - NCT00264680 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00264680) - NCT00266149 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00266149) - NCT00280059 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00280059) - NCT00292461 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00292461) - NCT00355082 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00355082) - NCT00395694 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00395694) - NCT00412191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00412191) - NCT00516139 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00516139) - NCT00605371 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00605371) - NCT00627575 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00627575) - NCT00807989 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00807989) - NCT00896987 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00896987) - NCT01357902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01357902) And 74 more, listed on the interactive page. ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 2 **Polar surface area** 90.71 **Calculated partition coefficient (ALogP)** 2.01 **Calculated partition coefficient (XLogP)** 1.4 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 1 **Heavy atoms** 16 **Molecular formula** C9H7Cl2N5 **Monoisotopic mass** 255.0078506 **Natural product** Yes ## National Drug Codes - 0115-1526 - 0115-1527 - 0115-1528 - 0115-1529 - 0115-9939 - 0115-9940 - 0115-9941 - 0115-9942 - 0173-0526 - 0173-0527 - 0173-0594 - 0173-0633 - 0173-0642 - 0173-0643 - 0173-0644 - 0173-0699 - 0173-0754 - 0173-0755 - 0173-0756 - 0173-0757 - 0173-0758 - 0173-0759 - 0173-0760 - 0173-0761 - 0173-0772 And 281 more, listed on the interactive page. ## Evidence counts **Recorded assays** 4,028 **Active assays** 32 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Anticonvulsants Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000927.html) - Calcium Channel Blockers Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D002121.html) - Antipsychotic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014150.html) - Sodium Channel Blockers Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D026941.html) ## Biological measurements ### Observed measurements #### Distribution coefficient (LogD) **Median** 1.225 **Mean** 1.225 **Minimum** 0.54 **Maximum** 1.91 **Unit** unitless **Assays** 2 **Standard deviation** 0.968736 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - LogD #### Solubility **Median** 307,000 **Mean** 307,000 **Minimum** 307,000 **Maximum** 307,000 **Unit** nM **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 1 **Unknown units excluded** 0 #### Measurement types - Solubility #### Oral bioavailability **Median** 79 **Mean** 79 **Minimum** 79 **Maximum** 79 **Unit** % **Assays** 1 **Standard deviation** 0 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (180) - 16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression - A Bioavailability Crossover Study of Two Formulations of Lamotrigine Extended Release Tablets in Healthy Subjects - A Bioequivalence Study of Two Formulations Lamotrigine 100 mg Tablets and Lamictal 100 mg Tablets in Healthy Adult Volunteers Under Fasting Conditions - A Clinical Evaluation Of BW430C (Lamotrigine) In Bipolar I Disorder- Long-term Extension Of Study SCA104779 (NCT00550407) - - A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode - A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women - A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice - A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis - A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures - A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine - A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil - A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) - A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults - A Study to Evaluate the Effect of Single Doses of Drug A (Lamotrigine) and Drug B (Vofopitant) Alone and in Combination on Resting Motor Threshold in Healthy Subjects - [A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants](https://trialight.com/data/trial/a-study-to-evaluate-the-effects-of-lithium-valproic-acid-and-ac5b7403-69ec-453c-8636-b56c489d7ff4.md) - A Study To Investigate The Antidepressant Effect Of Lamotrigine In Patients With Bipolar Disorder Using Lithium - Acute Treatment of Bipolar II Depression - AED/Statin Interaction Study - An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients - An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder ### Approved for (9) - Bipolar depression - [Bipolar disorder](https://trialight.com/data/condition/bipolar-disorder-a61ecd6f-6fb9-5323-bc0d-ebf861411d3c.md) - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) - [Epilepsy](https://trialight.com/data/condition/epilepsy-633a5321-bf08-5a6b-8459-d44b2b00904e.md) - Epilepsy with generalized tonic-clonic seizures - [Focal epilepsy](https://trialight.com/data/condition/focal-epilepsy-33745322-62b7-5575-aa6a-87e311f726cc.md) - Lennox-Gastaut syndrome - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) - [Visual epilepsy](https://trialight.com/data/condition/visual-epilepsy-9eee333f-f968-5e66-b952-f1f9696c6533.md) ### In development for (25) - Alcohol dependence Phase 2 - Anxiety Phase 3 - Childhood absence epilepsy Phase 3 - Cocaine dependence Phase 2 - [Cognitive disorder](https://trialight.com/data/condition/cognitive-disorder-76a28ab3-7660-5227-a8e7-3c697819853c.md) Phase 1 - [Dementia](https://trialight.com/data/condition/dementia-c61efc95-c071-50d2-9df7-acb34b2a720c.md) Phase 3 - Drug dependence Phase 2 - Eating disorder Phase 3 - Fish eye disease Phase 1 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - Meniere disease Phase 2 - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) Phase 1 - [Mood disorder](https://trialight.com/data/condition/mood-disorder-00c37338-ecb8-5997-bb93-d0ec3e6e3573.md) Phase 3 - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 2 - Neurofibromatosis type 1 Phase 2 - Neurotic excoriation Phase 2 - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 3 - [Opiate dependence](https://trialight.com/data/condition/opiate-dependence-75d4615b-1445-5bca-8b05-ae8266043d82.md) Phase 2 - Peripheral neuropathy Phase 3 - Post-traumatic stress disorder Phase 3 ### Other linked conditions (5) - Alcohol withdrawal - Facial nerve disorder - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) - Morbid obesity - Neuralgia ### Targets (10) - [SCN10A](https://trialight.com/data/target/scn10a-e64e3928-416a-5e6d-b348-81c46298a289.md) Sodium channel alpha subunit blocker - [SCN11A](https://trialight.com/data/target/scn11a-e3013f04-1b7e-5769-85f7-a85f520126d6.md) Sodium channel alpha subunit blocker - [SCN1A](https://trialight.com/data/target/scn1a-3473d408-b191-588e-8a54-6ea744fc0b86.md) Sodium channel alpha subunit blocker - [SCN2A](https://trialight.com/data/target/scn2a-58945297-e1b4-5bf0-977c-fff5460c4bc5.md) Sodium channel alpha subunit blocker - [SCN3A](https://trialight.com/data/target/scn3a-312e048c-0a82-5193-94d1-473a98b97a6e.md) Sodium channel alpha subunit blocker - [SCN4A](https://trialight.com/data/target/scn4a-49bb6125-30fd-58f5-8275-868382aee1cb.md) Sodium channel alpha subunit blocker - [SCN5A](https://trialight.com/data/target/scn5a-b122849c-977b-5d4c-a790-0245f1654eb5.md) Sodium channel alpha subunit blocker - [SCN7A](https://trialight.com/data/target/scn7a-8f79dda4-d450-5e5e-ade8-304fdd8afea0.md) Sodium channel alpha subunit blocker - [SCN8A](https://trialight.com/data/target/scn8a-05beb79a-ca39-5d8d-a99b-ee0fd0d5e8c4.md) Sodium channel alpha subunit blocker - [SCN9A](https://trialight.com/data/target/scn9a-6d55e0b8-9c24-5570-a1c0-5445020a13bf.md) Sodium channel alpha subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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