> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/jnj-54175446-90c8b1c3-c968-4060-b6e3-dd906e14f466
> Record changed: 2026-10-13

# JNJ-54175446

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

**Drug name**

JNJ-54175446

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

**Molecular weight**

440.79

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

**Structure (SMILES)**

C\[C@@H\]1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)c1cccc(C(F)(F)F)c1Cl

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

### Other names (9)

- jnj 54175446
- JNJ 54175446
- Jnj-54175446
- JNJ-54175446
- JNJ-54175446 (capsule)
- JNJ-54175446 150 mg
- JNJ-54175446 600 mg
- JNJ-54175446, 150 mg
- JNJ-54175446, 600 mg

## Identifiers

**CAS registry numbers**

- 1627902-21-9

**ChEMBL ID**

CHEMBL4079239

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

**InChIKey**

CWFVVQFVGMFTBD-SECBINFHSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4079239)

**PubChem compound IDs**

- 90409366

**FDA ingredient codes (UNII)**

- 32524GLF40

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Mechanisms of action

- **Mechanism**  
P2X purinoceptor 7 antagonist

**Action type**  
Antagonist

**Target**  
P2X purinoceptor 7

**Protein identifier**  
Q99572

### Open Targets mechanisms

- **Mechanism**  
P2X purinoceptor 7 antagonist

**Action type**  
Antagonist

**Target**  
P2X purinoceptor 7

### Investigated indications

- **Condition**  
Depressive Disorder, Major

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002009

**Subject identifier**  
D003865

### Open Targets indications (2)

- **Condition identifier**  
MONDO\_0002009

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002009

**Highest recorded phase**  
2

### Trial references

- NCT02902601  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02902601)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

0

**Polar surface area**

76.8

**Calculated partition coefficient (ALogP)**

3.63

**Calculated partition coefficient (XLogP)**

3

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

30

**Molecular formula**

C18H13ClF4N6O

**Monoisotopic mass**

440.0775494

**Natural product**

No

## Evidence counts

**Recorded assays**

92

**Active assays**

34

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (407)

- 12-Week Trial Investigating L-carnitine Tartrate, Dihydrocapsiate and Protein Yeast Hydrolysate on Energy Intake and Expenditure in Overweight Adults
- 14-C ADME (Absorption, Disposition, Metabolism and Excretion) Study in Man
- 3-part Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EXS21546
- 5-Way Crossover Study to Compare the Safety, Tolerability and Pharmacokinetics of New Oral Cannabinoid Formulations Administered as Single Doses, With Buccal Sativex®, in Healthy Volunteers
- A 28 Day Parallel Group Study to Assess the Effects of RDN-929
- [A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis](https://trialight.com/data/trial/a-3-part-study-of-syx-5219-in-healthy-volunteers-and-ad181b14-4ed6-4538-af9c-dfcb0bd8eab2.md)
- A 6 Months Double Blind Trial to Prevent PONV in Laparoscopic Cholecystectomy
- A Bioequivalence Study of Sanchi-Tongshu Capsule (Enteric Coated Pellets)
- A Clinical Study of Gulingji Capsule in the Treatment of Idiopathic Oligospermia, Asthenia, and Teratozoospermia
- A Clinical Study of Treating Influenza With Liugan Shuangjie Heji
- A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome
- A Clinical Study of Xin'an Medicine in the Treatment of Knee Osteoarthritis
- A Clinical Study on Qianjin Capsule of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Damp-heat Stasis and Qi Deficiency Syndrome)
- A Clinical Trial Evaluating TQF3250 Capsules in Healthy Adult Subjects
- A Clinical Trial of CS12192 in Healthy Subjects
- A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder
- A Clinical Trial of KT07 Capsule in the U.S.A
- A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors
- A Clinical Trial of TQH3906 Capsules in Healthy Volunteers
- A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis

### In development for (1)

- [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 1

### Targets (1)

- [P2RX7](https://trialight.com/data/target/p2rx7-756c9351-a304-5284-a58c-fdd4974efad3.md) P2X purinoceptor 7 antagonist

---

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