> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/izalontamab-brengitecan-3fa5e03e-9990-4789-b030-d605ef641b5f > Record changed: 2026-10-13 # Izalontamab brengitecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) **Drug name** Izalontamab brengitecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) ### Other names (21) - bl b01d1 - BL B01D1 \[WHO-DD\] - bl b01d1 who dd - BL-B01D1 - BL-B01D1 for Injection - bms 986507 - BMS-986507 - bms986507 - BMS986507 - fused g1 scfv heavy lambda heavy chain chimeric and homo sapiens 1 702 gamma1 heavy chain anti egfr chimeric 1 448 vh mus musculus ighv2 2 03 93 8 ighd ighj3 01 92 9 a128 s 119 cdr imgt 8 7 13 26 33 51 57 96 108 1 119 homo sapiens ighg1 08p 100 g1m3 1 ch1 i103 201 r120 216 120 217 hinge 1 15 218 232 ch2 233 342 ch3 d12 358 l14 360 343 447 chs k2 del 448 120 448 10 mer bis tetraglycyl seryl linker 449 458 scfv heavy lambda anti erbb3 homo sapiens 459 702 vh homo sapiens ighv3 7 01 91 8 ighd ighj2 01 100 cdr imgt 8 8 11 484 491 509 516 555 565 459 576 15 mer tris tetraglycyl seryl linker 577 591 v lambda homo sapiens iglv2 14 03 93 9 iglj2 01 83 3 l124 v 699 cdr imgt 9 3 11 617 625 643 645 682 692 592 702 222 214 disulfide with kappa light chain anti egfr chimeric 1 214 v kappa mus musculus igkv5 48 01 95 8 igkj5 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa substituted at the sulfur atoms of the l cysteinyl residues 214 214 222 222 228 228 231 231 with 3rs 1 4s 13s 21s 13 benzyl 1 carboxy 22 1s 9s 9 ethyl 5 fluoro 9 hydroxy 4 methyl 10 13 dioxo 2 3 9 10 13 15 hexahydro 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino 21 methyl 5 8 11 14 17 22 hexaoxo 20 oxa 2 6 9 12 15 18 hexaazadocosan 4 yl 2 5 dioxopyrrolidin 3 yl brengitecan groups - Fused G1-scFv heavy-lambda heavy chain chimeric and Homo sapiens (1-702) \[gamma1 heavy chain anti-EGFR chimeric (1-448) \[VH (Mus musculus IGHV2-2\*03 (93.8%) -(IGHD) -IGHJ3\*01 (92.9%) A128>S (119), CDR-IMGT \[8.7.13\] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1\*08p (100%), G1m3,1 (CH1 I103 (201), R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 D12 (358), L14 (360) (343-447), CHS K2>del (448)) (120-448)\] -10-mer bis(tetraglycyl-seryl) linker (449-458) -scFv heavy-lambda anti-ERBB3 Homo sapiens (459-702) \[VH (Homo sapiens IGHV3-7\*01 (91.8%) -(IGHD) -IGHJ2\*01 (100%), CDR-IMGT \[8.8.11\] (484-491.509-516.555-565)) (459-576) -15-mer tris(tetraglycyl-seryl) linker (577-591) -V-LAMBDA (Homo sapiens IGLV2-14\*03 (93.9%) -IGLJ2\*01 (83.3%) L124>V (699), CDR-IMGT \[9.3.11\] (617-625.643-645.682-692)) (592-702)\]\], (222-214')-disulfide with kappa light chain anti-EGFR chimeric (1'-214') \[V-KAPPA (Mus musculus IGKV5-48\*01 (95.8%) -IGKJ5\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atoms of the L -cysteinyl residues 214', 214''', 222, 222'', 228, 228'', 231, 231'' with (3RS)-1-\[(4S,13S,21S)-13-benzyl-1-carboxy-22-{\[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo\[de\]pyrano\[3',4':6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino}-21-methyl-5,8,11,14,17,22-hexaoxo-20-oxa-2,6,9,12,15,18-hexaazadocosan-4-yl\]-2,5-dioxopyrrolidin-3-yl (brengitecan) groups - Immunoglobulin G1 \[de-448-lysine\], anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 γ1-chain) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin anti-(human epidermal growth factor receptor HER3) (human clone HER3.H3 single-chain variable fragment VH-(GGGGS)3-VL), complex with human-mouse monoclonal C225 κ-chain, dimer, 214′′,214′′′,222,222′,228,228′,231,231′-octakis(thioether) with (2S)-N-(carboxymethyl)-2-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-β-alanylglycylglycyl-L-phenylalanyl-N-\[\[(1S)-2-\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]-1-methyl-2-oxoethoxy\]methyl\]glycinamide - immunoglobulin g1 de 448 lysine anti human epidermal growth factor receptor human mouse monoclonal c225 γ1 chain fusion protein with peptide linker ggggs 2 fusion protein with immunoglobulin anti human epidermal growth factor receptor her3 human clone her3 h3 single chain variable fragment vh ggggs 3 vl complex with human mouse monoclonal c225 κ chain dimer 214 214 222 222 228 228 231 231 octakis thioether with 2s n carboxymethyl 2 3 mercapto 2 5 dioxo 1 pyrrolidinyl β alanylglycylglycyl l phenylalanyl n 1s 2 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino 1 methyl 2 oxoethoxy methyl glycinamide - immunoglobulin g1 scfv l kappa dimer anti homo sapiens egfr epidermal growth factor receptor receptor tyrosine protein kinase erbb 1 erbb1 her1 her 1 erbb and anti homo sapiens erbb3 receptor tyrosine protein kinase erbb 3 her3 chimeric and homo sapiens monoclonal antibody tetravalent bispecific conjugated to a camptothecin derivative - Immunoglobulin G1-scFv\_L-kappa dimer, anti-\[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)\] and anti-\[Homo sapiens ERBB3 (receptor tyrosine protein kinase erbB-3, HER3)\], chimeric and Homo sapiens monoclonal antibody, tetravalent, bispecific, conjugated to a camptothecin derivative - izalontamab brengitecan - Izalontamab brengitecan - izalontamab brengitecan \[INN\] - IZALONTAMAB BRENGITECAN \[USAN\] - izalontamab brengitecan inn - izalontamab brengitecan usan ## Identifiers **CAS registry numbers** - 2760528-47-8 **ChEMBL ID** CHEMBL5314841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314841) **FDA ingredient codes (UNII)** - UC2FX6YY3P ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mab; -tecan ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (5) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005494 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Glycosylation sites (N) **Sequence** 88 $ 88'' $ 299 $ 299'' - **Component** Heavy chain **Type** Protein **Sequence** QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVT - **Component** Disulfide bridges **Sequence** 22-95 $ 22''-95'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 222-214' $ 222''-214'''$ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427'' $ 480-554 $ 480''-554'' $ 613-681 $ 613''-681'' - **Component** Light chain **Type** Protein **Sequence** DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (51) - A Study Comparing BL-B01D1 Combined With Tislelizumab Versus Platinum-containing Chemotherapy Combined With Tislelizumab as First-line Treatment in Patients With Extensive-stage Small Cell Lung Cancer(PANKU-Lung07) - A Study Comparing BL-B01D1 in Combination With Osimertinib Versus Osimertinib Alone in Patients With Locally Advanced, Unresectable EGFR-mutated Non-small Cell Lung Cancer(Stage III) Whose Disease Has Not Progressed Following Definitive Platinum-based Chemoradiation Therapy(PANKU-Lung08) - A Study Comparing BL-B01D1 in Combination With PD-1/VEGF Bispecific Antibody Versus Chemotherapy in Combination With PD-1/VEGF Bispecific Antibody in First-line Patients With Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer(PANKU-Lung05) - A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus01) - A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Urothelial Carcinoma(PANKU-Bladder01) - A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced or Metastatic Triple-Negative Breast Cancer(PANKU-Breast02) - A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+/HER2- Breast Cancer After Failure of Prior Endocrine Therapy(PANKU-Breast03) - A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01) - A Study Comparing BL-B01D1 With Docetaxel in Patients With Unresectable Locally Advanced or Metastatic EGFR Wild-type Non-small Cell Lung Cancer(PANKU-Lung02) - A Study Comparing BL-B01D1 With Physician's Choice of Chemotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma(PANKU-NPC01) - A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer(PANKU-Lung01) - A Study Comparing BL-B01D1 With the Investigator's Choice of Chemotherapy in Patients With Platinum-resistant Recurrent Epithelial Ovarian Cancer(PANKU-GYN01) - A Study Comparing BL-B01D1 With Topotecan in Patients With Recurrent Small Cell Lung Cancer(PANKU-Lung03) - A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally Advanced or Metastatic Biliary Tract Cancer After Failure of Platinum-based Chemotherapy(PANKU-BTC01) - A Study Evaluating BL-B01D1 in Combination With a PD-1/VEGF Bispecific Antibody Versus Tislelizumab Plus Platinum-doublet Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer(PANKU-Lung06) - A Study of Anti-PD-1 Antibody With or Without BL-B01D1 as Maintenance Therapy Following Anti-PD-1 Antibody Plus Chemotherapy for the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma (PANKU-NPC02) - A Study of BL-B01D1 + PD-1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma - A Study of BL-B01D1 + Pembrolizumab ± Bevacizumab in Patients With Recurrent or Metastatic Cervical Cancer and Endometrial Cancer - A Study of BL-B01D1 and Almonertinib in Patients With Resectable EGFR+ Stage II-IIIB NSCLC - A Study of BL-B01D1 and BL-B01D1 in Combination With Osimertinib Mesylate Tablets in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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